Hemophagocytic Lymphohistiocytosis Related to Tuberculosis Disease

JOURNAL TITLE: Indian Journal of Critical Care Medicine

Author
1. Begüm Koç
2. Sevinç Kalın
3. Betül Sözeri
4. Deniz Çakır
5. Seher Erdoğan
6. Burcu Karakayalı
7. Tuğçe Bozkurt
ISSN
0972-5229
DOI
10.5005/jp-journals-10071-23329
Volume
24
Issue
1
Publishing Year
2020
Pages
2
Author Affiliations
1. com.mps.common.model.Contributor@13cbbeac ,
2. com.mps.common.model.Contributor@1db194aa ,
3. com.mps.common.model.Contributor@519d4c13 ,
4. com.mps.common.model.Contributor@d8c91e5 ,
5. com.mps.common.model.Contributor@43fc6026 ,
6. com.mps.common.model.Contributor@5279a837 ,
7. com.mps.common.model.Contributor@693f8bbf
Article keywords
Hemophagocytic lymphohistiocytosis, Therapeutic plasma exchange, Tuberculosis

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare, albeit potentially fatal, condition in which fever, hepatosplenomegaly, and cytopenia predominate the clinical picture. Although it may be primary, it may also develop secondary to various etiologies. Herein, we aimed to report a patient who was diagnosed with pulmonary tuberculosis, developed fever and cytopenia during follow-up, and received immunomodulatory therapy together with antituberculosis therapy for the diagnosis of HLH. Sequencing of PRF1 showed heterozygous mutation. Although primary HLH has been detected in infants and children, genetic mutation of genes should be considered a differential diagnosis of HLH even in the adolescent.

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