Severe Periodontal Disease Manifested in Chronic Disseminated Type of Langerhans Cell Histiocytosis in a 3-Year Old Child

JOURNAL TITLE: International Journal of Clinical Pediatric Dentistry

Author
1. Vineeta Gupta
2. Manish Bansal
3. Rajesh Bansal
4. Monika Bansal
5. Shashikant Patne
6. Vinay Kumar Srivastava
ISSN
0974-7052
DOI
10.5005/jp-journals-10005-1269
Volume
7
Issue
3
Publishing Year
2014
Pages
3
Author Affiliations
    1. Department of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh India
    1. Department of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh India
    1. Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
    2. Institute of Medical Sciences, Varanasi, Uttar Pradesh, India
    1. Medanta - The Medicity, Gurgaon, Haryana, India
    2. Medanta Heart Institute, Medanta–The Medicity, Gurgaon, Haryana, India
    3. Medanta—The Medicity, Gurgaon, Haryana, India
    4. Medanta–The Medicity, Gurugram, Haryana, India
    5. Medanta Hospital, Gurugram, Haryana, India
    6. Medanta: The Medicity, Gurgaon, Haryana, India
    7. Medanta—The Medicity, Gurugram, Haryana, India
    8. Medanta - The Medicity, Gurugram, Haryana, India
    9. Medanta – The Medicity, Gurugram, Haryana, India
    10. Heart Institute, Medanta—The Medicity, Gurugram, Haryana, India
    11. Medanta Heart Institute, Medanta – The Medicity, Gurugram, Haryana, India
    1. Department of Pathology, Faculty of Modern Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Article keywords
    Floating teeth, Langerhans cell histiocytosis, Osteolytic lesion, Seborrheic dermatitis

    Abstract

    Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is a rare idiopathic disorder of reticulo-endothelial system with abnormal proliferation of bone marrow derived Langerhans cells along with a variable number of leukocytes, such as eosinophils, neutrophils, lymphocytes and plasma cells. Three years old male child presented with multifocal osteolytic lesions and papulosquamous skin lesions. Clinical and radiographic features, such as severe alveolar bone loss, mobility of teeth, precocious eruption of teeth, floating appearance of teeth in orthopantomogram (OPG), osteolytic lesion in skull and cutaneous lesions were highly suggestive of LCH disease. Skin biopsy confirmed a diagnosis of LCH. Induction chemotherapy with oral prednisolone and intravenous vinblastine was started. Child responded well to chemotherapy. The clinical significance of the presented case is to diagnose the case of LCH on the basis of the manifestation of severe periodontal disease as this can be first or only manifestation of LCH. A dentist plays a major role in the multidisciplinary treatment of LCH through routine examination and periodic follow-up. How to cite this article: Bansal M, Srivastava VK, Bansal R, Gupta V, Bansal M, Patne S. Severe Periodontal Disease Manifested in Chronic Disseminated Type of Langerhans Cell Histiocytosis in a 3-Year Old Child. Int J Clin Pediatr Dent 2014;7(3):217-219.

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