Statement of problem: Interactions are suspected between resin coating and elastomeric impression material. Purpose: The purpose of this study was to identify possible interactions between two impression materials and resin-coated tooth surfaces. Materials and methods: Extracted molars (n = 10) underwent 1 of the 4 procedures: control group (unsealed tooth surface/impression); IDS group (immediate dentin sealing/impression); IDS/AB group (immediate dentin sealing/air blocking/impression); IDS/AB-P group (immediate dentin sealing/air blocking/pumicing/impression). Dentin bonding agents used were Adper single bond 2 and Clearfil SE bond. Impression materials used were Impregum Soft (polyether) and Aquasil (A silicone). A stereomicroscope was used to detect any residual impression material on the bonded tooth surface. Results: The IDS group showed 100% faulty impressions. Air blocking the resin coating did not completely eliminate the oxygen-inhibited layer of Adper single bond 2. Clearfil SE Bond along with Aquasil generated ideal impressions in group IDS/AB, while all other combinations resulted in faulty impressions. The IDS/AB-P group yielded ideal impressions with Aquasil but generated faulty impressions with Impregum soft in most specimens. Conclusion: Immediate dentin sealing should be followed by air blocking and pumicing to generate ideal impressions with Aquasil (A silicone). Impregum Soft (polyether) is not recommended in combination with immediate dentin sealing.