The present case describes a rare and large size of giant keratoacanthoma (KA) of pinna.

Keratoacanthoma is a fast growing benign cutaneous tumor resembling closely to well-differentiated squamous cell carcinoma (SCC) on clinical and histopathological examination (HPE).

A 70-year-old male presented with a rapidly growing mass on the left ear for 9 months. Tumor was excised and sent for HPE, which revealed well-differentiated SCC with focal features of a KA.

Differentiation of KA from SCC has been a major challenge for dermatosurgeons, especially at setups with unavailability of molecular studies. So, if the tumor is giant, nonregressing in size especially on sun-exposed sites in an elderly patient, always think of SCC and treat it by surgical excision rather than watching for a spontaneous resolution.

Chauhan S, Thakur K, Garg A, Tegta GR, Chauhan P. Giant Keratoacanthoma of Pinna: A Rare Presentation. Int J Head Neck Surg 2017;8(1):31-33.