Sinonasal Mucormycosis in a Tertiary Care Center: A Review of 30 Cases

JOURNAL TITLE: International Journal of Head and Neck Surgery

Author
1. Amit Kumar Gupta
2. Annanya Soni
ISSN
0975-7899
DOI
10.5005/jp-journals-10001-1394
Volume
11
Issue
3
Publishing Year
2020
Pages
3
Author Affiliations
    1. Department of ENT, GSVM Medical College, Kanpur, Uttar Pradesh, India
    1. Department of General Surgery, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India
  • Article keywords

    Abstract

    Aim and objective: To report our experience in presentation, treatment, and outcome of rhino-orbito-cerebral mucormycosis in our institute. Materials and methods: Retrospective, noncomparative analysis of medical records of 30 patients with mucormycosis seen over a period of 5 years. Results: Data of 30 patients, 22 males and 8 females with a mean age of 47.3 (range 25–70 years), were analyzed. Total 25 patients had diabetes mellitus, 3 were post-renal transplant, and 2 were post-bone marrow transplant and on immunosuppressive drugs. Ophthalmic signs and symptoms were present in 12 patients, and intracranial involvement was present in 11 patients. Computed tomography/magnetic resonance imaging (CT/MRI) revealed involvement of paranasal sinuses in all patients. All were treated with amphotericin-B (3–7 g) and 29 patients underwent appropriate surgery. Posaconazole/caspofungin was started as adjuvant treatment in certain cases. Conclusion: Mucormycosis is a rapidly spreading fungal disease with high mortality and demands immediate management without delay and generous debridement.

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