Metformin throughout Pregnancy in Women with Polycystic Ovary Syndrome: Safety and Advantages

JOURNAL TITLE: International Journal of Infertility & Fetal Medicine

Author
1. P Palshetkar Nandita
2. D Pai Hrishikesh
3. Takhtani Manisha
4. Rutvij Jay Dalal
5. Saxena Nidhi
6. Bharti Bansal
ISSN
2229-3817
DOI
10.5005/jp-journals-10016-1019
Volume
2
Issue
2
Publishing Year
2011
Pages
4
Author Affiliations
    1. Lilavati Hospital IVF Centre, Mumbai, India; Fortis Bloom IVF Centre, New Delhi, India; DY Patil Fertility Centre, Navi Mumbai, Maharashtra, India
    2. Nova IVI Fertility Clinic, Ahmedabad, Gujarat, India
    1. Fellow of the National Board of Examinations (FNB) in the Subspecialty of Reproductive Medicine, Lilavati Hospital and Research Center Mumbai, Maharashtra, India
    1. Lilavati Hospital and Medical Research Centre, Mumbai, Maharashtra, India
    1. Lilavati Hospital and Medical Research Centre, Mumbai, Maharashtra, India
    1. Lilavati Hospital and Medical Research Centre, Mumbai, Maharashtra, India
    1. Bloom IVF Enterprises, Mumbai, Maharashtra, India
  • Article keywords

    Abstract

    Objective

    To study the incidence of spontaneous abortions, congenital malformations, neonatal and maternal hypoglycemia after metformin therapy in pregnancy.

    Design

    Prospective study.

    Setting

    Outpatient.

    Patient(s)

    56 women previously oligomenorrheic, nondiabetic women with polycystic ovarian syndrome, who conceived while on metformin.

    Intervention(s)

    Metformin 1 to 1.5 gm/day throughout pregnancy.

    Main outcome

    Incidence of 1st trimester abortions, gestational diabetes, teratogenicity and maternal complications, like gastritis and hypoglycemia.

    Results

    On metformin, the incidence of 1st trimester abortion was 11% and the incidence of gestational diabetes was 7%, which is much lower than the incidence otherwise cited for PCOS women. No major congenital abnormalities were observed.

    Conclusion

    Metformin therapy in pregnancy reduces the otherwise high incidence of 1st trimester abortions, and gestational diabetes in PCOS women is tolerated well and is not found to be teratogenic.

    © 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved