Aim: The study aims at evaluating the glycated hemoglobin and serum sialic acid as risk factors in patients with myocardial infarction, who are nondiabetic. Materials and methods: This is a case-control study performed on the population of north coastal Andhra Pradesh. All the subjects got admitted to King George Hospital/Andhra Medical College which is a major referral hospital to the people of north coastal Andhra Pradesh. One hundred subjects participated in the study, of which 50 had myocardial infarction and are nondiabetic, and the rest are controls who never had myocardial infarction. Glycated hemoglobin and serum sialic acid levels were estimated, and results analyzed for the association. Statistical analysis was done using SPSS software. Results: Glycated hemoglobin and serum sialic acid levels are significantly increased in patients with myocardial infarction who are nondiabetic. Conclusion: Persistent hyperglycemia levels not surmounting to diabetes can be a significant risk factor in the development of myocardial infarction. Clinical significance: This study helps us to identify the role of persistent hyperglycemia not mounting to diabetes as a significant cardiovascular risk factor.