Vitamin B12 and Holotranscobalamin Levels in Diabetic Peripheral Neuropathy Patients

JOURNAL TITLE: Indian Journal of Medical Biochemistry

Author
1. Mohammed Noorjahan
2. Kandregula Madhavi
3. Chandran Priscilla
4. Shaik A Jabeen
ISSN
0972-1207
DOI
10.5005/jp-journals-10054-0004
Volume
20
Issue
1
Publishing Year
2016
Pages
5
Author Affiliations
    1. Department of Biochemistry and Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
    1. Department of Biochemistry and Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
    1. Department of Biochemistry and Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
    1. Department of Biochemistry and Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
  • Article keywords

    Abstract

    Results

    In the DMWN group, vitamin B12 levels were significantly higher than in the DMWON group and controls [1013 (564-1501) pmol/l, 387 (245-731) pmol/l, and 305 (234-472) pmol/l respectively]. Similarly, serum holoTC was also found to be significantly higher in the DMWN [203.8 (129-300) pmol/l] group compared with the DMWON [94.4 (42.2-230.6) pmol/l] group and controls [74 (40-170) pmol/l]. Whereas mean levels of homocysteine and folate did not show any significant difference between groups, significant increase in fasting blood sugar and HbA1c was seen in the DMWN group compared with DMWON group and controls. Duration of diabetes is also significantly more in DMWN group compared with DMWON group.

    Conclusion

    We found that vitamin B12 and holoTC levels were high in patients with DMWN and DMWON groups compared with controls. Our study demonstrated that peripheral neuropathy was not associated with vitamin B12 deficiency in diabetics. These findings merit further research on a larger population to investigate into the cause of diabetic neuropathy, the factors involved, and benefit of vitamin B12 supplementation in these patients.

    Key messages

    Vitamin B12 status has no association with diabetic peripheral neuropathy.

    How to cite this article

    Noorjahan M, Madhavi K, Priscilla C, Jabeen SA. Vitamin B12 and Holotranscobalamin Levels in Diabetic Peripheral Neuropathy Patients. Indian J Med Biochem 2016;20(1):16-20.

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