Introduction: Periimplantitis is defined as an inflammatory process affecting the tissues around an osseointegrated implant in function, resulting in loss of supporting bone and, if allowed to progress, can result in loss of the implant. The frequency of periimplantitis ranging between 28 and 56% had been reported. To date, there is little evidence to indicate the most effective method of treatment for periimplantitis. This case series describes a regenerative treatment for restoration of bone and reduction of probing depth (PD) around a periimplantitis-affected implant. Materials and methods: After nonsurgical therapy, three patients underwent complete debridement and decontamination followed by usage of various combinations of regenerative materials to correct the defects, i.e., osseograft, healiguide, and platelet-rich fibrin (PRF). Implant surface modification was done with laser. Clinical and X-ray parameters were recorded at baseline and 6 months follow-up. Results: A 6 months follow-up showed that the periimplant tissues were healthy and stable. Radiographic examination revealed the matured bone fill. No progression of bone loss was detected. Conclusion: Elucidation of factors of importance for peri-implant tissue destruction should make it easier to predict which patient or implant is at risk for peri-implant complications during maintenance and retention of implants. Complete debridement and decontamination are crucial in treating periimplantitis and still remain the “gold standard.”