Background: Peripheral giant cell granuloma is a benign reactive lesion of the oral cavity, originating from the periosteum or periodontal membrane in response to local irritation or chronic trauma. It may develop at any age but is frequently seen in the fifth to sixth decade and shows female predilection. Materials and methods: Various techniques ranging from conventional scalpel to electric scalpel and cryosurgery have been used for the excision of this lesion. This article describes a case reporting the successful use of Er,Cr:YSGG laser for complete excision of the lesion with minimal discomfort to the patient. Results: Immediate coagulation was achieved without any use of sutures and excellent wound healing was observed after 1 week. Conclusion: The benefits offered by the use of this laser excision technique indicates that it should be considered as an efficient tool for similar soft tissue lesions in the oral cavity.