Introduction: Change in voice in the patient of laryngopharyngeal reflux is a common symptom. In this study, we are assessing the improvement in severity of the laryngopharyngeal reflux disease by its symptoms, signs, severity, and videostroboscopy to detect even earliest change and document it. Materials and methods: A prospective study in 50 subjects at a tertiary referral center who were subjected to answer a questionnaire of the voice handicap index, the reflux symptom index, and assessed reflux finding score and vocal fold mucosa changes by videostroboscopy. All subjects were reassessed after 12 weeks of treatment. Result: Improvement was found statistically significant (<0.05) in all parameters and scales. Conclusion: Preventing the insult by acid reflux in the laryngeal mucosa by proton pump inhibitors resulted in improvement of symptoms and signs, which proves the efficacy of treatment. Videostroboscopy is a useful tool to early diagnose the lesion.