Isoniazid.induced Thrombocytopenia in a Patient with Ocular Tuberculosis

JOURNAL TITLE: Indian Journal of Respiratory Care

Author
1. Preeti Gupta
2. Ajay Kumar Verma
3. Rishabh Chaudhary
4. Hemant Kumar
5. Utkarsh Kumar Srivastava
ISSN
2277-9019
DOI
10.4103/ijrc.ijrc_48_18
Volume
8
Issue
2
Publishing Year
2019
Pages
3
Author Affiliations
    1. VMMC and Safdarjung Hospital, New Delhi, India
  • Article keywords
    Antitubercular therapy, isoniazid, thrombocytopenia

    Abstract

    Antitubercular therapy (ATT)-induced thrombocytopenia is a rare and serious adverse drug reaction which may be fatal if not identified timely. Although rifampicin is the common culprit ATT causing thrombocytopenia, other ATTs such as isoniazid have also been reported to cause thrombocytopenia. Here, we report a case of isoniazid-induced thrombocytopenia in a 56-year-old female with ocular tuberculosis who developed multiple purpura on both upper limbs, face, and oral cavity. Her condition improved with the withdrawal of isoniazid.

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