Pulmonary embolism (PE) is a major manifestation of venous thromboembolism (VTE). Obstructive sleep apnea (OSA) leads to hypercoagulable state and may be associated with recurrent PE in the absence of deep vein thrombosis (DVT). Early identification and treatment of OSA may be helpful in reducing the recurrence of PE. Here, we report a case of OSA presenting with isolated PE without DVT with a brief mention of therapeutic implications.