Non-specific chronic low back pain is common and complex and has a large impact on individuals and society. Inculcating physical exercise to promote healthy lifestyle has played an important role in the prevention and management of chronic health conditions. The purpose of this article is to review the published literature on lifestyle factors mainly physical exercise to combat non-specific chronic low back pain. PubMed database was reviewed from January 2000 to November 2018 and searched for ‘exercise and non-specific chronic low back pain’, ‘lifestyle and nonspecific chronic low back pain’ and individual exercise interventions and non-specific chronic low back pain. Articles which fulfilled the criteria were included in the final review. The available evidences from existing systematic reviews and articles suggested that physical exercise does improve pain severity and physical function in chronic non-specific low back pain. Regarding the type of exercises, strengthening or resistance exercises seem to be effective but no specific type of exercise is superior to others. Incorporating physical exercise such as strengthening exercises as part of the lifestyle change could combat non-specific chronic low back pain.