Oral squamous cell carcinoma (OSCC) is a well known malignancy which accounts for more than 90% of all oral cancers. OSCC are malignant tumors that frequently invade bone and bone invasion is a common clinical problem. Bone invasion by oral squamous cell carcinoma may progress by either an infiltrative or an erosive histological pattern. The pattern of bone invasion co-relates with the clinical behavior of OSCC thus having a potential prognostic value. The present case report is of a 35-year- old female patient presenting with a lesion in the lower right buccal vestibule which was histopathologically confirmed as OSCC. The type of bony invasion was also assessed microscopically. The objective of this paper was to define the characteristics associated with each histological pattern of invasion and its significance when reviewing oral squamous cell carcinoma with mandibular invasion.