A Quantitative Analysis of Mast Cells in Inflammatory Periapical and Gingival Lesions

JOURNAL TITLE: The Journal of Contemporary Dental Practice

Author
1. NS Priya
2. K Uma
3. HS Umadevi
4. T Smitha
5. Kavita Rao
ISSN
DOI
10.5005/jp-journals-10024-1532
Volume
15
Issue
3
Publishing Year
2014
Pages
6
Author Affiliations
    1. Aditya Jyot Eye Hospital Private Limited, Mumbai, Maharashtra, India
    2. Aditya Jyot Eye Hospital, Mumbai, Maharashtra, India
    1. Department of Oral Pathology, VS Dental College, Bengaluru, Karnataka, India
    1. Department of Oral and Maxillofacial Pathology, KLE Dental College and Hospital, Bengaluru, Karnataka, India
    1. Department of Oral and Maxillofacial Pathology, VS Dental College, Bengaluru, Karnataka, India
    1. Department of Oral and Maxillofacial Pathology, VS Dental College, Bengaluru, Karnataka, India
  • Article keywords

    Abstract

    Aim

    The aim of the study was to quantify the presence of mast cells in various inflammatory lesions like periapical granuloma, periapical cyst, inflammatory gingival hyperplasia and pyogenic granuloma. Mast cell degranulation and association with lymphocytes were also recorded in an attempt to understand the role of mast cells in the pathogenesis of these inflammatory lesions.

    Materials and methods

    The quantification of mast cells was done on toluidine blue stained sections of all the four groups of lesions, using the image analyzer software, Image-Pro-Express (Media Cybernetics, USA).

    Results

    An increased number of mast cells in various inflammatory lesions with a significant difference between the four groups were noted. Mast cell number tended to be greater in the lesions present in the anterior region of the mouth than in the posterior region of the oral cavity. The mean mast cell number decreased with the increasing age which was directly correlated with the age of the patients. Mast cell site, distribution, degranulation and its association with fibroblasts, lymphocytes and blood vessels were noted.

    Conclusion

    The location of mast cells in different areas, their association with lymphocytes, fibroblasts, endothelial cells, and the phenomenon of degranulation helps to appreciate the release of various mediators and multiple interactions among these cells, leading to increased vascular permeability, angiogenic response, collagen synthesis, regulation of inflammation, bone resorption, and extracellular matrix destruction, thus contributing to the pathogenesis of these inflammatory lesions.

    How to cite this article

    Sheethal HS, Uma K, Rao K, Priya NS, Umadevi HS, Smitha T. A Quantitative Analysis of Mast Cells in Inflammatory Periapical and Gingival Lesions. J Contemp Dent Pract 2014;15(3):300-305.

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