Mycoplasma is the smallest living-free organism in the nature. It is an important and common cause of respiratory infections. It mainly affects children more than 5 years of age and younger adult causing disease of varied severity of illness from asymptomatic or upper respiratory infection to severe pneumonias. Hemolytic anemia is known as a rare but severe complication of Mycoplasma infection. We encountered a 15-year-old male with cold agglutinin antibody-associated fatal autoimmune hemolytic anemia secondary to Mycoplasma pneumonia hence reported.