Background: In this study, we aim to report the clinical and laboratory profile of 187 coronavirus disease 2019 (COVID-19) patients admitted to a tertiary care hospital in Jaipur, Rajasthan, India. Materials and methods: Case records were accessed retrospectively, and demographic profile, clinical presentation, and two laboratory markers [neutrophil:lymphocyte ratio (NLR) and C-reactive protein (CRP)] were evaluated in 187 patients with confirmed COVID-19 infection. Patients were divided into two groups for analysis—recovered/discharged group and mortality group. Results: In our study, the mortality rate was 11.8% (22 out of 187 cases) with similar age and sex distribution between the two groups. A higher proportion of patients in the mortality group had severe disease as compared to the recovered group (72.7 vs 8.5%). Patients who died had a longer mean duration of symptoms before admission (5.2 vs 3.3 days), with a lower duration of hospital admission (5.6 vs 10.6 days) as compared to the recovered group. Fourteen out of 22 patients in the mortality group required non-invasive or invasive ventilatory support at admission, compared to 21 out of 165 patients who recovered; and 86.4% of patients who died had comorbidities vs 43.6% of those who recovered. The mean NLR was over 3.5 times higher and mean CRP at admission nearly 2.6 times higher in the mortality group.