Epidemiology and Genotypes of Hepatitis C Virus: A First Study from Jammu (J&K), India

JOURNAL TITLE: Journal of Gastrointestinal Infections

Author
1. Monika Sharma
2. Shelly Sehgal
3. Mamta Sharma
4. Konika Razdan
5. Shashi S Sudhan
6. Bharti Pandita
ISSN
2277-5862
DOI
10.5005/jp-journals-10068-0003
Volume
7
Issue
1
Publishing Year
2017
Pages
6
Author Affiliations
    1. Christian Medical College (CMC) and Hospital, Ludhiana, Punjab, India
    2. Christian Medical College and Hospital, Ludhiana, Punjab, India
    3. College of Nursing, DMC & Hospital, Ludhiana, Punjab, India
    4. Apollo Centre for Obesity, Diabetes and Endocrinology, Indraprastha Apollo Hospital, New Delhi, India
    1. Department of Oral Medicine and Radiology, Indira Gandhi Govt. Dental College & Hospital, Jammu, Jammu and Kashmir India
    1. Centre for Molecular Biology, Central University of Jammu Jammu and Kashmir, India
    1. Department of Microbiology, Government Medical College Jammu, Jammu and Kashmir, India
    1. Department of Microbiology, Government Medical College Jammu, Jammu and Kashmir, India
    1. School of Biotechnology, University of Jammu, Jammu and Kashmir, India
  • Article keywords
    Chronic liver disease, Genotyping, Hepatitis C virus, Seroprevalence

    Abstract

    Background and objectives Globally, around 200 million people are infected with hepatitis C virus (HCV). India contributes a big proportion of HCV burden with the prevalence estimated between 0.5 and 1.5%. Northeastern tribal populations and areas of Punjab represent the HCV infection hotspots, while in Western and Southern parts of the country, the prevalence is lower. The distribution of HCV genotypes is highly variable. This study was particularly planned to attain knowledge of the prevalent HCV genotypes in Jammu province of Jammu and Kashmir (J&K) state. Materials and methods Blood samples of patients attending the Department of Medicine, Government Medical College (GMC), Jammu and Kashmir, India, for HCV testing were subjected to serological test at Department of Microbiology, GMC, Jammu. The serum samples were tested for anti-HCV antibodies by enzyme-linked immunosorbent assay (ELISA) and positive samples were subjected to genotyping. Conclusion Of the 396 samples tested, 33 (8.33%) were found to be HCV positive and 23 of these were included for genotyping. Genotypes 3 and 1 were detected in this region and this was in accordance with other national studies. There is a need for larger field studies to better understand the HCV epidemiology and identify higher prevalence areas and also the distribution of genotypes of HCV. This, being a maiden study from this region, will shed light to allow apposite choice and target efforts for better management of the disease and reduce the burden of chronic liver disease due to HCV. How to cite this article Sharma M, Sehgal S, Sudhan SS, Razdan K, Pandita B, Sharma M. Epidemiology and Genotypes of Hepatitis C Virus: A First Study from Jammu (J&K), India. J Gastro Infect 2017;7(1):9-14.

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