Background and objectives: Enteric fever, caused by Salmonella enterica serovar S. Typhi and enterica serovar Paratyphi A, B and C is a major health problem worldwide. A progressive increase in antibiotic resistance has been reported among these organisms recently. This study aimed to estimate the prevalence of fluoroquinolone resistance among S. Typhi and S. Paratyphi isolates from a tertiary care hospital in northern India. Materials and methods: This retrospective study included Salmonella isolates obtained from the blood samples received in microbiology laboratory from January to December 2017. Blood specimens were processed using an automated blood culture system (BACTEC 9240/Bac-T-Alert). Antimicrobial susceptibility testing to ciprofloxacin and levofloxacin was performed using a fully automated Vitek-2 system. Results: A total of 376 Salmonella enterica isolates were obtained; 294 (78.2%) were identified as S. Typhi, and 82 (21.8%) as S. Paratyphi A. Incidence of ciprofloxacin-resistant strains of S. Typhi was 67.3% and that of S. Paratyphi A was 97.6%. Another 32.6% of S. Typhi and 2.4% S. Paratyphi A isolates showed decreased susceptibility to ciprofloxacin (MICs 0.25 -0.5 ìg/mL). For levofloxacin, 25.8% of S. Typhi and 51.2% of S. Paratyphi A were resistant. Another 73.5% of S. Typhi and 48.8% of S. Paratyphi A isolates showed decreased susceptibility to levofloxacin (MICs 0.25–1 ìg/mL). Interpretation and conclusion: The incidence of S. Typhi and S. Paratyphi A isolates showing resistance or reduced susceptibility towards fluoroquinolone is very high in northern India.