Introduction: The periodontitis affected teeth and the observed changes in the dental pulp have been controversial area of debate. The reason being the close communication between the periodontium and the pulp through the apical foramina and accessory lateral canals postulating the spread of infection between the tissue areas. Aim: Evaluation of the histopathologic changes in dental pulp of teeth with moderate and severe chronic periodontitis. Materials and methods: Human dental pulp was obtained using vital pulpectomy technique from 20 permanent teeth extracted due to hopeless periodontal prognosis. Pulp tissue samples were processed for histological examination and grading of changes observed. Result: Inflammation was usual finding in the samples; however, only 8% of the teeth showed no inflammation. Pulp with moderate fibrosis was seen commonly in many sections. About 44% of samples showed edematous pulp. Conclusion: Periodontitis can induce changes in the dental pulp considerations have to be given to the involved teeth for the depth of pocket and severity of periodontal involvement for proper treatment planning and management.