Systemic Lupus Erythematosus Presenting with Thrombotic–Thrombocytopenic Purpura-like Syndrome and Catatonia

JOURNAL TITLE: Journal of Postgraduate Medicine, Education and Research

Author
1. Gaurav Vohra
2. Jasmine Sethi
ISSN
2277-8969
DOI
10.5005/jp-journals-10028-1332
Volume
53
Issue
4
Publishing Year
2019
Pages
2
Author Affiliations
    1. Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    1. Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • Article keywords
    Catatonia, Systemic lupus erythematosus, Thrombotic microangiopathy, Thrombotic–Thrombocytopenic purpura

    Abstract

    Systemic lupus erythematosus (SLE) can present with thrombotic microangiopathy (TMA), and differentiating this from thrombotic thrombocytopenic purpura can be a challenging task. Though thrombotic–thrombocytopenic purpura (TTP) is a type of TMA demonstrating a severely reduced activity of VWF, cleaving protease ADAMTS 13 can differentiate it from other causes of TMA. Association of TTP-like TMA and catatonia in lupus is not described in literature. Neuropsychiatric lupus presenting as catatonia is uncommon. Here we describe a 41-year-old female who was presented with TTP-like TMA and catatonic symptoms, which improved with plasma-exchange, benzodiazepines, and immunosuppression.

    © 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved