Systemic Lupus Erythematosus Presenting with Thrombotic–Thrombocytopenic Purpura-like Syndrome and Catatonia

JOURNAL TITLE: Journal of Postgraduate Medicine, Education and Research

Author
1. Sandeep Grover
2. Gaurav Vohra
3. Jasmine Sethi
ISSN
2277-8969
DOI
10.5005/jp-journals-10028-1332
Volume
53
Issue
4
Publishing Year
2019
Pages
1
Author Affiliations
1. com.mps.common.model.Contributor@3d93af4e ,
2. com.mps.common.model.Contributor@3e7a0da ,
3. com.mps.common.model.Contributor@692a0142
Article keywords
Catatonia, Systemic lupus erythematosus, Thrombotic microangiopathy, Thrombotic–Thrombocytopenic purpura

Abstract

Systemic lupus erythematosus (SLE) can present with thrombotic microangiopathy (TMA), and differentiating this from thrombotic thrombocytopenic purpura can be a challenging task. Though thrombotic–thrombocytopenic purpura (TTP) is a type of TMA demonstrating a severely reduced activity of VWF, cleaving protease ADAMTS 13 can differentiate it from other causes of TMA. Association of TTP-like TMA and catatonia in lupus is not described in literature. Neuropsychiatric lupus presenting as catatonia is uncommon. Here we describe a 41-year-old female who was presented with TTP-like TMA and catatonic symptoms, which improved with plasma-exchange, benzodiazepines, and immunosuppression.

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