Impact on Fertility in Patients with Hematological Malignancies and Bone Marrow Transplant

JOURNAL TITLE: Journal of Postgraduate Medicine, Education and Research

Author
1. Chandan K Das
2. Arihant Jain
3. Gaurav Prakash
ISSN
2277-8969
DOI
10.5005/jp-journals-10028-1337
Volume
53
Issue
4
Publishing Year
2019
Pages
2
Author Affiliations
1. com.mps.common.model.Contributor@31534e9c ,
2. com.mps.common.model.Contributor@1edc653e ,
3. com.mps.common.model.Contributor@2c33e451
Article keywords
Bone marrow transplant, Cancer, Chemotherapy, Fertility, Hematology, Preservation

Abstract

With the rapidly improving outcome of patients suffering from hematologic disorders and cancers, there exists a rapidly widening gap of unmet need regarding fertility preservation in this group. Hematologic cancers make for a large proportion of all cancers in young patients and there are issues peculiar to hematologic neoplasms which are not observed by the patients suffering from solid tumors. The biggest challenge is seen with the patients undergoing hematologic stem cell transplants because it involves use of high doses of cytotoxic chemotherapy with or without radiation. In majority of these cases, the damage to gonadal function is irreversible. Each hematologic disorder in young patients poses a unique challenge regarding fertility preservation. In this review, we address some important aspects related to fertility in patients suffering from a few selected hematologic disorders.

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