Aim and objective: To ascertain the determinants of health, nutrition profile differentials, and leisure activities of students of Panjab University (PU). Materials and methods: This cross-sectional study was conducted in PU, Chandigarh, from January 2018 to April 2018 among undergraduate and postgraduate students. Respondents consisted of 300 students (150 hostellers, 150 day-scholars) from medical, non-medical, and arts and commerce streams. The health-promoting lifestyle profile (HPLP) tool was used for collecting the data. Results: The mean value of the HPLP score was 133.95 (SD ± 14.05). Those pupils who had better HPLP scores had good nutrition profiles. A higher HPLP score of the participants was associated with more indulgence in leisure activities. Almost two-thirds of the pupils who had a good nutrition profile had normal body mass index (BMI). The majority of the students, who indulged more in leisure activities, also had better nutritional status. Conclusion: Almost two-thirds of the day-scholars had a good nutrition profile and they were able to keep their health at good levels. Half of the hostellers had poor nutrition profiles; they were not taking care of their health. Students with higher HPLP scores had a better nutritional profile. They were found more energetic and more active in leisure activities. Thus, promotion of the status of health, nutrition profile, and leisure time activities of university students will enhance their quality of life.