Aim and objective: To ascertain the health-related determinants of differences in the academic performance and health profile of hostellers and day scholars of a North Indian University, Chandigarh. Materials and methods: This cross-sectional study was conducted at North Indian University, Chandigarh. Respondents were 300 students (150 hostellers, 150 day scholars) from three streams, that is, medical, nonmedical, and arts and commerce. Data analysis was done with the help of MS Excel and a statistical package for the social sciences (SPSS). A comparison between hostellers and day scholar students regarding their academics was made. Findings were considered statistically significant if the p-value was less than or equal to 0.05. Results: Overall, 300 students of North Indian University were studied. The mean academic performance score was 4.44 [standard deviation (SD) ± 0.88]. Undergraduate (UG) students had better academic performances than postgraduates (PG). With an increase in age, there was declining order in academic performances seen. Students of nonmedical streams were extremely good in their academics than medical and arts/commerce students. Most of the students had problems related to the ear, eyes, nose, throat, and oral cavity. Day scholar students had better health status profiles than hostellers. Conclusion: The majority of the hostellers had a good academic performance. Only one-third of day scholars were good in academics. Day scholar students had good medical health status than those who stayed at the hostel.