Aim: We aim to describe an unusual case of disseminated nocardiosis in a patient with steroid-dependent nephrotic syndrome and its successful management with medical therapy alone. Background: Nocardia infection is uncommon in clinical practice, with most cases occurring as the result of opportunistic infection in immunocompromised patients. Here, we report a case of disseminated nocardiosis with brain abscesses in a patient with nephrotic syndrome. Case description: We report a middle-aged female with steroid-dependent nephrotic syndrome with disseminated nocardiosis. The patient was managed with imipenem/cilastatin, oral trimethoprim/sulfamethoxazole (TMP/SMX), and amikacin for 4 weeks followed by dual therapy with co-amoxiclav and TMP/SMX for 6 months. The patient had both clinical and radiological recovery. Clinical significance: The present case indicates the risk of life-threatening infection in patients receiving steroids and the need for prophylactic therapy to prevent serious infections during the course of steroid therapy.