Chronic leg ulcers are a major cause of mortality and morbidity. The efficacy of hyperbaric oxygen treatment is being evaluated in the management of nonhealing leg ulcers to improve skin graft survival. We are presenting a case of nonhealing ulcer where skin graft was rejected three succeeding times. Súrūta has indicated Visrāvaṇa or Raktamokṣaṇa (bloodletting) in the management of ulcers. Jalaukāvacāraṇa (leech application) is one of the methods of Raktamokṣaṇa (bloodletting). A case report of 27-year-old female patient was presented with the complaints of swelling over the right ankle joint, with chronic lymphadenitis referred by the plastic surgeon. She was diagnosed as nonhealing ulcer and was treated by the plastic surgeon and skin grafting was performed. But it failed three succeeding times. Her constitution rejected all three skin grafts. This patient was then treated with Jalaukāvacāraṇa (bloodletting through leech application) after fourth time skin graft and it was accepted thereafter.