Purpose: To evaluate and compare marginal integrity, marginal discoloration, and retention rates of Embrace-WetBond (EW), Helioseal-F (HF), and Clinpro (CL) sealants in permanent molars. Materials and methods: Sealants were applied on 90 permanent mandibular molars in 48 children aged 6–14 years with deep pit and fissures, and evaluation of these sealants was performed using Ryge and Synder's criteria at 0, 2, 4, 6, 8, and 12 months. Results: Embrace-WetBond showed maximum marginal integrity (83.3%) as compared to CL (73.3%) and HF (60%) at the end of 12 months. Lack of marginal discoloration was highest in EW (93.3%) as compared to CL (76.7%) and HF (80%) at the end of 12 months. Embrace-WetBond showed highest retention (96.7%) as compared to CL (80%) and HF (73.3%) at the end of 12 months. The results were, however, statistically insignificant (p > 0.05). Conclusion: Embrace-WetBond sealant is better than CL and HF in terms of retention.