Single Nucleotide Polymorphisms in CD14 and Toll-like Receptor 4 Genes in Patients with Polycystic Ovarian Syndrome

JOURNAL TITLE: Journal of South Asian Federation of Obstetrics and Gynaecology

Author
1. Nazima Allauddin
2. Roya Rozati
ISSN
0974-8938
DOI
10.5005/jp-journals-10006-1518
Volume
9
Issue
4
Publishing Year
2017
Pages
4
Author Affiliations
    1. Owaisi Hospital and Research Centre, Deccan College of Medical Sciences, Mahavir Hospital and Research Centre, MHRI-Centre for Fertility Management, Hyderabad
    2. Centre for Fertility Management, Banjara Hills, Hyderabad, Andhra Pradesh, Mahavir Hospital and Research Center, Hyderabad, Andhra Pradesh, India
    3. Owaisi Hospital and Research Center, Deccan College of Medical Sciences, Hyderabad, Telangana, India
    1. Department of Obstetrics and Gynecology, Deccan College of Medical Sciences, Hyderabad, Telangana, India
  • Article keywords

    Abstract

    Introduction

    Polycystic ovary syndrome (PCOS) is a complex disease having genetic, immunologic, and environmental components, and candidate genes on innate immunity have been hypothesized to be involved in its etiology. We examined the possible association of CD14 and toll-like receptor 4 (TLR4) polymorphisms with PCOS.

    Materials and methods

    A total of 219 women with PCOS and 272 healthy women were recruited in the study. Their samples were genotyped for the polymorphism of CD14 and TLR4 genes.

    Results

    The distributions of genotypes of both polymorphisms were found to be significant in women with PCOS compared with controls. The distributions of alleles were also found to be predominant in PCOS compared with controls.

    Conclusion

    Polymorphisms in CD14-159C>T and TLR4-299A>G significantly increased susceptibility to PCOS. Further studies with larger sample sizes are warranted to confirm these findings.

    How to cite this article

    Allauddin N, Rozati R. Single Nucleotide Polymorphisms in CD14 and Toll-like Receptor 4 Genes in Patients with Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):304-307.

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