Aim: The aim of the study was to find out the correlation between the mean platelet volume in the late 1st trimester of pregnancy and development of a Preeclampsia later on. Materials and methods: It was a prospective cohort study in which 500 pregnant women (11–14 weeks of gestation) were enrolled and their mean platelet volume (MPV) was measured. They were followed till delivery. MPV of pre-eclamptic and normotensive women was compared. Results: MPV of pre-eclamptic women was significantly higher than that of the normotensive women (p = 0.001). Conclusion: MPV >10.55 fL was found to be 68.7% sensitive and 55.9% specific for the prediction of Preeclampsia with a negative predictive value of 87.6%.