Background: It has been estimated from retrospective community surveys that nearly 90% of women have experienced at least one premenstrual syndrome (PMS). Premenstrual syndrome is more prevalent among younger women. It also has a negative impact on the quality of life (QoL) to such a degree that work and lifestyle may get affected. Objective: To find the association between PMS and the body mass index (BMI) and its effect on the QoL. Materials and methods: A total of 207 females in the age group of 18–25 years were screened using the Moos menstrual distress questionnaire for PMS, of which 57 volunteers were diagnosed with PMS. Baseline characteristics were recorded, BMI was calculated, and QoL of all subjects was measured using the SF-36 questionnaire. Outcome measures: Body mass index, Moos menstrual distress questionnaire, SF-36 questionnaire. Results: The results showed a significant correlation between PMS and the physical component summary (r value = −0.4228, p value = 0.0011) and also between PMS and the mental component summary (r value = −0.4326, p value = 0.0008). However, there was no significant correlation between PMS and BMI. Conclusion: Premenstrual syndrome has a negative impact on QoL; however, no association with BMI was observed.