Role of Prenatal Diagnosis in Parents with Sex Chromosomal Abnormality: A Review

JOURNAL TITLE: Journal of South Asian Federation of Obstetrics and Gynaecology

Author
1. Pritti K Priya
2. Hetvi Patel
ISSN
0974-8938
DOI
10.5005/jp-journals-10006-1682
Volume
11
Issue
3
Publishing Year
2019
Pages
5
Author Affiliations
    1. Department of Obstetrics and Gynecology, GR Doshi and Smt KM Mehta Institute of Kidney Diseases and Research Centre, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, Gujarat, India
    1. Department of Public Health Dentistry, Pacific Dental College & Hospital, Udaipur, Rajasthan, India
  • Article keywords
    Down syndrome, Klinefelter\'s syndrome, Prenatal diagnosis, Sex chromosome abnormality, Triple X syndrome, Turner syndrome

    Abstract

    Sex chromosome aneuploidy is defined as a numeric abnormality of an X or Y chromosome and includes 45,X (Turner syndrome); 47,XXY (Klinefelter's syndrome); 47,XXX; and 47,XYY karyotypes. Individuals with 47,XXX and 47,XXY are generally fertile, but there is a risk of having a cytogenetically abnormal child in them. Turner and Klinefelter's syndromes are frequently associated with infertility, but few cases have been reported that they were able to give birth to a normal child as well as some children were born with similar or some other chromosomal abnormalities. Triple X syndrome occurs in 0.1% of live-born female newborns. Most of these newborns have a normal phenotype and only a few cases with 47,XXX karyotype have congenital malformations. These female patients may be mostly fertile, but there appears to be an increased risk of a cytogenetically abnormal child; the extent of this risk cannot yet be determined. Therefore, prenatal diagnosis and genetic analysis are therefore recommended. We report a rare case of triple X woman with a history of a Down syndrome child, for which she was advised a prenatal diagnosis in her subsequent pregnancy, and a review of other pertinent articles to establish the role of a prenatal diagnosis in parents with a sex chromosomal abnormality.

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