Dysmenorrhea has no long-lasting therapeutic strategy despite the advances in medicine. The European medicinal plants such as Valeriana officinalis, Passiflora incarnata and Humulus lupulus have been used as folklore remedy in the past century. However, they have not reached the masses due to paucity of information in the leading medical journals. This article reviews the clinical benefits and possible mechanism of action of these medicinal plants in the treatment of dysmenorrhea. We also suggest this fixed dose combination in the management of dysmenorrhea in daily clinical practice.