Early treatment of skeletal class III becomes necessary in growing patients to prevent the future deterioration of the existing malocclusion and avoiding the complex orthognathic surgical procedures to correct the same. This case series explains two different treatment modalities for growing patients with skeletal class III malocclusion with anterior crossbite, who have differing degree of growth potential, growth pattern, facial profile, lip competency and strain, amount of skeletal discrepancy, and intra-arch relationships. The treatment goals have been achieved efficiently in each situation, due to prompt diagnosis and utilization of proper treatment mechanics.