Typhoid fever continues to ravage across the globe. It affects young children and causes higher morbidity and mortality in them. The Diseases of the Most Impoverished (DOMI) study has added invaluable data regarding the disease incidence. The bacteria had developed resistance to the first generation of antimicrobials. Fluoroquinolones and recently third-generation cephalosporins have been found to be ineffective and extremely drug resistance typhoid had surfaced in certain regions. Vaccines are an important tool in the ongoing fight against typhoid fever.