Opioids is a natural and synthetic painkillers derived from the poppy plant used for medication. Opioids, are called narcotics, a type of drug. The commonly used opioids are morphine, codeine, heroin, opium, oxymorphone, tramadol used as a strong prescription for relieving pain. Opioids dependence syndrome needs the compulsive and uncontrollable use of opioid drugs causing adverse consequences. Dependency occurs when the body adapts to the presence of the drug, causing withdrawal symptoms when drug use is reduced or discontinued. The prevalence of opiod use in India was found to be 0.7% of the general population and 22.3% were found to be dependent on opiods. The patient is presented with elated or euphoric state, intermittent nodding off, depression, drowsiness, lethargy even loss of consciousness. The co-occurring mental disorders include bipolar disorder, anxiety disorders, depressive disorders, schizophrenia, conduct disorder, personality disorder. The mainstay of treatment includes detoxification therapy and psychological therapy.