Parathyroid Carcinoma in a Center Routinely Using ioPTH: A Case Series

JOURNAL TITLE: World Journal of Endocrine Surgery

1. Virginia Rozalén García
2. Michael Shawky
3. Mechteld C de Jong
4. Tom R Kurzawinski
5. Tarek E Abdel-Aziz
Publishing Year
Author Affiliations
1. com.mps.common.model.Contributor@4360e48e ,
2. com.mps.common.model.Contributor@fbd74ee ,
3. com.mps.common.model.Contributor@4c917578 ,
4. com.mps.common.model.Contributor@78bea620 ,
5. com.mps.common.model.Contributor@3c3e692d
Article keywords
Management, Outcomes, Parathyroid carcinoma, PTH


Aim: Parathyroid carcinoma (PC) is a rare endocrine malignancy and therefore limited data are currently available. In this case series, we describe our institution\'s experience with PC and patients’ outcomes. Background: The course of PC ranges from indolent to progressive disease with an uncontrollable hypercalcemia and widespread metastases. No clear guidelines toward diagnosis as well as management currently exist owing to a lack of prospective data. Case description: Here, we present a case series of 12 patients who underwent treatment for PC at our institution. All patients were diagnosed after surgery. At time of surgery, three patients (25.0%) underwent a concomitant hemithyroidectomy owing to abnormal features. An additional four patients (33.3%) underwent a hemithyroidectomy on the side of their PC. None of our patients received any adjuvant medical therapy. One patient (8.3%) was found to have recurrent disease; this patient is currently alive with disease. Conclusion: In conclusion, although no uniform management strategy was observed during the included period, overall outcomes were good, with a recurrence rate of less than 10%. Clinical significance: PC is a very uncommon malignancy that imposes both diagnostic and management uncertainties. The current report describes the management and outcomes of a series of 12 patients with this disease. All patients were only diagnosed after surgery as having a PC. Moreover, possibly due to a lack of prospective data, all patients in our series underwent different surgical treatment strategies. Nonetheless, overall, both short- and long-term outcomes were satisfactory, with a less than 10% recurrence rate. However, this series does underline the importance of more prospective research regarding diagnostic, treatment, and prognostic variables for PC.

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