Background: The effects of fiber-reinforced acrylic base liner on peri-implant structures in early loading implant-supported overdenture are not thoroughly investigated. Hence, the aim to this study was to evaluate the effect of fiber-reinforced acrylic denture base resin liner on clinical and radiographic parameters in early loading implant supported overdentures. Materials and methods: Fifteen edentulous male patients, aged 50–60 years were randomly (lottery method) classified into two groups: group I (controls, n = 5) having 4 ball and socket implants without resilient liner, group II (study group, n = 10) having ball and socket attachments with resilient liner. Group II was further divided into two subgroups: subgroup A (n = 5) having 2 ball and socket implants with resilient liner and subgroup B (n = 5) having 3 ball and socket implants with resilient liner. Implant mobility, implant survival, sulcular depth around the implant and bone height were evaluated every 3 months for 1 year. General linear models were used to test the difference in the mean crevicular depth and mean bone height (ratio) around implants in both groups during the follow-up periods. Statistical significance was determined at α = 0.05. Results: No mobility was reported and the implant survival was 100%. There was an increase in the mean crevicular depth around implants in both groups at different time intervals. The increase was higher in group II (p < 0.05). There was a decrease in the mean bone height around the implants in both groups at different time intervals; however, this difference was not statistically significant (p > 0.05). Conclusion: Furthermore, the number of implants had no significant role in the success or failure of the implant-supported overdentures.