Aim: To compare and evaluate oxygen-releasing gel vs 0.2% chlorhexidine (CHX) gel as an adjuvant to scaling and root planning (SRP). Materials and methods: A total of 11 patients (22 sites) with chronic periodontitis were randomly assigned into test and control groups by the flip of a coin method. Pre-op clinical parameters recorded were plaque index (PI), gingival index (GI), probing pocket depth (PPD), and wound healing index (WHI). Post-completion of SRP, test group (n = 11) received subgingival delivery of oxygen-releasing gel and control group (n = 11) received 0.2% CHX gel. A periodontal pack and oral hygiene instructions (OHI) were given. Post-op clinical parameters were measured at 1 and 3 months. Results: The intergroup comparison of test sites (oxygen-releasing gel) with the control sites (0.2% CHX gel) showed a statistically higher significant reduction in test group when compared to control group in periodontal parameters such as PPD (p < 0.0001), clinical attachment level (CAL) (p < 0.0001), WHI (p, 0.0001). However, no statistically significant difference was found in PI and GI between both groups. Conclusion: Oxygen-releasing gel, when used as a local drug delivery, showed better results when compared to the current gold standard, that is, 0.2% CHX gel in the nonsurgical management of moderately deep pockets in chronic periodontitis. Clinical significance: Nonsurgical periodontal therapy lays the foundation for most periodontal procedures. It also stands a chance of higher acceptability to the patients. Hence, whenever the clinical situation is conducive, oxygen-releasing gel serves to be an excellent local drug delivery alternative.