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The Diabetic Foot
Robert J. Hinchliffe, Nicolaas C. Schaper, Matt M. Thompson, Ramesh K. Tripathi
SECTION 1: GENERAL ASPECTS
CHAPTER 1:
Epidemiology of diabetic foot disease and etiology of ulceration
■ INTRODUCTION
■ BACKGROUND
■ FOOT ULCER: PREVALENCE AND INCIDENCE IN INDIVIDUALS WITH DIABETES MELLITUS
■ METHODOLOGICAL CONSIDERATIONS WITH REGARD TO INCIDENCE AND PREVALENCE OF FOOT ULCER
■ ETIOLOGY OF FOOT ULCER IN INDIVIDUALS WITH DIABETES MELLITUS
■ INCIDENCE AND PREVALENCE OF DIABETES-RELATED LOWER LEG AMPUTATION
■ Asia
■ Africa
■ Australasia
■ The Americas
■ METHODOLOGICAL CONSIDERATIONS WITH REGARD TO INCIDENCE AND PREVALENCE OF LOWER LEG AMPUTATION
■ CONCEIVABLE PITFALLS IN THE REGISTRATION OF DIABETES-RELATED AMPUTATIONS
■ Indication for amputation
■ SELECTION OF AMPUTATION LEVEL
■ ADDITIONAL CONFOUNDERS WHEN COMPARING AMPUTATION-RELATED DATA
■ AMPUTATION AS A MARKER OF QUALITY OF CARE
CHAPTER 2:
Diabetic foot assessment and classification of risk
■ BACKGROUND AND HISTORY
■ PATHOPHYSIOLOGY
■ ANGIOPATHY
■ NEUROPATHY
■ STRUCTURAL ABNORMALITIES/GAIT ABNORMALITIES
■ SCREENING
■ History and visual screening
■ Neurological examination
Monofilament testing
Vibration testing
■ Dermatological examination
■ Vascular examination
■ RISK CLASSIFICATION
■ Diabetes mellitus foot risk classification (risk of ulceration and subsequent amputation)
■ Wound classification systems (risk of nonhealing and subsequent amputation)
Wagner classification for foot ulcers
University of Texas wound classification system
PEDIS system
■ Management of tissue loss, infection, and ischemia: the importance of team
■ CONCLUSION
CHAPTER 3:
Setting up a diabetic foot service
■ INTRODUCTION
■ REALIZATION OF DIABETIC FOOT SERVICES: A SHORT HISTORY
■ MULTIDISCIPLINARY DIABETIC FOOT CARE APPROACH
■ Multidisciplinary approach in the developed world: experience from Europe
■ MULTIDISCIPLINARY APPROACH IN THE DEVELOPING WORLD
■ Singapore
■ Brazil
■ India
■ Tanzania
■ HOW TO START A DIABETIC FOOT SERVICE
■ INTERNATIONAL GUIDELINES ON THE DIABETIC FOOT
■ DIABETIC FOOT SERVICE AT A PRIMARY CARE LEVEL
■ Minimal model clinic
■ DIABETIC FOOT SERVICE AT SECONDARY CARE LEVEL
■ Intermediate model foot clinic
■ PATHWAYS OF CARE
■ ENSURING QUALITY OF DIABETIC FOOT CARE
■ RESOURCES FOR THE DEVELOPMENT AND SUSTAINABILITY OF DIABETIC FOOT CARE SERVICES
CHAPTER 4:
Economic aspects of foot care
■ INTRODUCTION
■ THE HUMAN COST
■ Incidence and prevalence
■ Quality of life
■ Prognosis and mortality
■ THE FINANCIAL COST
■ THE QUALITY OF CARE
■ ASSESSING THE COST-EFFECTIVENESS OF NEW INTERVENTIONS
■ Example: The Multidisciplinary Team (MDT) at The James Cook University Hospital, Middlesbrough, England
■ Interpreting the results of cost-effectiveness analysis
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 5:
Medical therapy and metabolic control to optimize cardiovascular risk and reduce overall mortality
■ INTRODUCTION
■ QUANTIFYING CV RISK IN DFU
■ EVIDENCE OF CV RISK MODIFICATION IN DFU
■ BLOOD PRESSURE CONTROL
■ LIPID MODIFICATION
■ GLYCEMIC CONTROL
■ Glucose targets
■ Glycemic control for ulcer prevention and healing
■ MULTIDISCIPLINARY CARE
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 6:
Psychological aspects of diabetes-related foot disease
■ INTRODUCTION
■ MEASURING THE IMPACT OF DIABETES-RELATED FOOT DISEASE
■ THE IMPACT OF DIABETES-RELATED FOOT DISEASE
■ Neuropathy
■ Arthropathy
■ Ulceration
■ Amputation
■ Demands of care
■ DEPRESSION AND ANXIETY IN DIABETES-RELATED FOOT DISEASE
■ THE INFLUENCE OF PSYCHOLOGICAL STATE ON OUTCOME IN DIABETES-RELATED FOOT DISEASE
■ SUMMARY
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 7:
Diabetes self-management education for the preservation of patient and foot health and the prevention of foot ulcers and amputations
■ INTRODUCTION
■ DEFINITIONS
■ HISTORY OF DIABETES AND PATIENT EDUCATION
■ HISTORY OF THE DIABETIC FOOT
■ PATIENT EDUCATION: AN ESSENTIAL PART OF DIABETES CARE
■ Guiding the review and revision of the DSME Standards
■ Measuring the success of DSME
Education outcomes measures
■ EDUCATIONAL INTERVENTIONS TO PREVENT FOOT ULCERATIONS
■ Content of a patient orientated prevention program as part of a coordinated process of diabetic foot care
■ Interaction of health-care providers and patient education
■ Do all patients with diabetes need the same level of education?
■ Is preventive patient education regarding diabetic foot conditions evidence-based?
■ Improving access to quality of patient education and foot care
■ PATIENT DIABETIC FOOT EDUCATION AS PART OF A DIABETIC FOOT PREVENTION PROGRAM
■ COST-EFFECTIVENESS OF PREVENTIVE MEASURES
■ SPECIAL CONSIDERATIONS FOR DEVELOPING COUNTRIES
■ Are we accomplishing the actions that we are advocating in Europe?
■ What can be learnt from the IDF and IWGDF?
■ Marketing aspects of patient education
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 2: INFECTION
CHAPTER 8:
Managing infection in the diabetic foot
■ INTRODUCTION
■ PATHOPHYSIOLOGY OF INFECTIONS IN DIABETES MELLITUS
■ Cellular innate immune system
■ Humoral innate immune system
■ Adaptive immune system
■ RISK FACTORS FOR DIABETIC FOOT INFECTION
■ CLINICAL SIGNS AND SYMPTOMS
■ CLASSIFICATION
■ PEDIS and IDSA
■ MICROBIOLOGY
■ Molecular microbiology
■ TREATMENT
■ Uninfected wounds
■ Infected wounds
General measurements
Systemic antimicrobial therapy
Mild infections
Moderate infections
Severe infections
Switch to oral antibiotics and duration of antibiotic therapy
■ ADJUNCTIVE THERAPY
■ Topical treatment
■ Hyperbaric oxygen treatment
■ Effectiveness of surgery
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 9:
Diabetic foot osteomyelitis: diagnosis and classification
■ INTRODUCTION
■ DIAGNOSIS
■ History and physical examination
■ Microbiology
■ Imaging studies
■ Classification
■ CONCLUSIONS
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 10:
Osteomyelitis: medical management
■ INTRODUCTION
■ INDICATIONS FOR MEDICAL THERAPY
■ PATIENT SELECTION
■ DIAGNOSIS
■ TREATMENT REGIMENS
■ OUTCOMES OF MEDICAL THERAPY
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 11:
Osteomyelitis: surgical management
■ INTRODUCTION
■ ANATOMICAL BASIS OF SURGERY FOR DIABETIC FOOT OSTEOMYELITIS
■ CLINICAL PRESENTATION OF DIABETIC FOOT OSTEOMYELITIS REQUIRING SURGERY
■ REMOVING THE INFECTED BONE: TYPES OF SURGERY
■ Amputation
■ Conservative surgery without amputation in cases of forefoot osteomyelitis
■ Conservative surgery in midfoot osteomyelitis
■ Conservative surgery in hindfoot osteomyelitis
■ WHEN SHOULD SURGERY BE PERFORMED?
■ HOW MUCH BONE SHOULD BE REMOVED?
■ FACTORS RELATED TO SURGERY OUTCOME
■ RECURRENCE AFTER SURGERY
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 3: ISCHEMIA
CHAPTER 12:
Peripheral arterial disease in diabetes
■ INTRODUCTION
■ PREVALENCE OF PERIPHERAL ARTERIAL DISEASE IN THE GENERAL POPULATION
■ PREVALENCE OF PAD IN PEOPLE WITH DIABETES
■ NATURAL HISTORY OF PERIPHERAL ARTERIAL DISEASE IN THE GENERAL POPULATION
■ Asymptomatic PAD
■ Intermittent claudication
■ Critical limb ischemia
■ NATURAL HISTORY OF PERIPHERAL ARTERIAL DISEASE IN DIABETES
■ AREAS OF CONTROVERSY AND/ OR FUTURE RESEARCH
CHAPTER 13:
Microvascular disease
■ INTRODUCTION
■ THE ANATOMY AND PHYSIOLOGY OF THE SKIN MICROCIRCULATION
■ Microvascular structure of the skin
■ The regulation of skin blood flow
Central regulation of skin blood flow
Local reflexes
Local autoregulation and the venoarteriolar axon reflex
■ Endothelium-dependent regulation
■ STRUCTURAL MICROVASCULAR ABNORMALITIES IN THE DIABETIC FOOT
■ ASSESSMENT OF MICROVASCULAR FUNCTION AND ABNORMALITIES OBSERVED IN THE DIABETIC FOOT
■ Laser Doppler flowmetry
■ Laser Doppler imaging
■ Assessment of endothelial function using iontophoresis and laser Doppler
■ Transcutaneous oxygen tension measurement
■ Photoplethysmography
■ Capillaroscopy
■ Hyperspectral imaging
■ PATHOGENESIS OF MICROANGIOPATHY AND IMPAIRED NUTRITION IN DIABETIC FOOT SKIN
■ The hemodynamic hypothesis
■ The capillary steal syndrome
■ THE ROLE OF ENDOTHELIAL DYSFUNCTION IN DIABETIC MICROANGIOPATHY
■ DIABETIC MICROANGIOPATHY AND CLI
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 14:
The diagnosis of peripheral arterial disease
■ INTRODUCTION
■ SYMPTOMS OF PERIPHERAL ARTERIAL DISEASE
■ Intermittent claudication
■ Critical limb ischemia
■ CLINICAL EXAMINATION
■ ANKLE BRACHIAL PRESSURE INDEX
■ Measurement of the ABPI
■ Prognostic value of ABPI
■ The pole test
■ Treadmill test
■ TOE PRESSURE MEASUREMENT
■ TISSUE PERFUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 15:
Imaging of peripheral arterial disease
■ INTRODUCTION
■ ULTRASONOGRAPHY
■ Modalities
B-mode ultrasound
Doppler
Color Doppler
Contrast-enhanced ultrasound
Advantages and limitations of ultrasound
■ COMPUTED TOMOGRAPHY ANGIOGRAPHY
■ Basic technology and principles
■ Optimizing contrast exposure
■ Radiation exposure
■ Post-processing
■ Uses in PAD
■ Advantages and limitations of CTA
■ MAGNETIC RESONANCE ANGIOGRAPHY
■ Basic technology and principles
■ Uses in PAD
■ Advantages and limitations of MRA
■ GADOLINIUM
■ DIGITAL SUBTRACTION ANGIOGRAPHY
■ Basic technology and principles
■ Contrast and contrast toxicity
■ Contrast-induced nephrotoxicity
■ Uses in PAD
■ Advantages and limitations of DSA
■ CO2 ANGIOGRAPHY
■ ROTATIONAL ANGIOGRAPHY/CONE BEAM CT
■ INTRAVASCULAR ULTRASOUND
■ Basic technology and principles
■ Uses in PAD
■ Advantage and limitations of IVUS
■ OPTICAL COHERENCE TOMOGRAPHY
■ MOLECULAR IMAGING
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 16:
Angiosomes
■ INTRODUCTION
■ THE ANGIOSOME CONCEPT
■ VASCULAR ANATOMY OF ANGIOSOMES IN THE FOOT
■ CURRENT GUIDELINES
■ CHALLENGES FOR ANGIOSOME-BASED REVASCULARIZATION
■ Evidence-based challenges
■ Technical challenges
■ Clinical challenges
■ Logistic challenges
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
■ ACKNOWLEDGMENT
CHAPTER 17:
Distal bypass techniques
■ INTRODUCTION
■ BYPASS TECHNIQUES
■ Selecting inflow site
Concomitant iliac stenosis
Femoral and profunda femoris artery disease and exposure
Distal SFA and popliteal artery as inflow source
■ Surgical exposure: key points
■ Selecting outflow site
Target vessel
Exposure of target vessels
Posterior tibial artery
Anterior tibial artery
Dorsalis pedis artery
Peroneal artery
Conduits for infrainguinal bypass
■ Synthetic graft material
Surgical modifications of prosthetic vascular grafts
Graft materials and coatings
Protein and drug modifications
Endothelial cell seeding
■ Biological graft material
Autogenous GSV
GSV diameter
GSV length: ‘short vein graft’
Vein compliance, sclerosis, and varicosities
Contralateral GSV
Alternate vein conduits (SSV and arm veins)
Cryopreserved venous allografts
■ Vein harvesting: technical points (Figure 17.4)
Preoperative marking
■ Continuous versus bridge incisions: do minimally invasive/endoscopic techniques help?
■ Dissection: no touch technique – periadventitial or with surrounding fat
Longitudinal and angular stretch
Checking compliance: gentle inflation
Repairing holes/tear and ligating side branches
Irrigating solution
Pharmacological adjuncts
Vein ischemia time
■ Autogenous vein graft configuration
■ Reversed vein graft
Nonreversed vein graft
In situ vein graft
■ Graft positioning and tunnels
Anatomic tunneling
Subcutaneous tunneling
■ Sutures and anastomoses
Suture material
Managing calcified arteries
■ Special techniques and their variations
Thromboembolectomy
Endarterectomy and patch plasty (patch angioplasty)
Fasciotomy
Distally originating SVG
Sequential bypass
Adjunctive differential AV fistula (dAVF)
Sartorius flap
Distal anastomosis – adjunctive procedures
Prostaglandin infusion
■ FOLLOW-UP AFTER DISTAL BYPASS
■ Best medical therapy
Cardiovascular risk factor control
Statins
Anticoagulation versus antiplatelet: type of graft is a deciding factor
■ Revascularization edema after distal bypass
■ Surveillance of patency of the distal bypass graft
■ Early recognition with timely reintervention for failing grafts
Factors causing graft failure
Mechanisms of vein graft failure
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 18:
Angioplasty techniques
■ INTRODUCTION
■ INDICATIONS FOR PTA
■ REVASCULARIZATION FEASIBILITY
■ EFFECTIVENESS OF PTA
■ COMPLICATIONS
■ Anesthesia
Hospital stay
■ Stress
■ Repeatability/costs
■ RESTENOSIS
■ REVASCULARIZATION AFTER FAILED ANGIOPLASTY
■ ANTITHROMBOTIC THERAPY
■ TECHNOLOGICAL INNOVATIONS
■ VASCULAR ACCESS
■ FEMOROPOPLITEAL ARTERIES
■ Subintimal angioplasty
■ Retrograde popliteal access
■ Dedicated devices for revascularization of femoropopliteal occlusions
Devices designed to remain in the true lumen
Devices designed to facilitate re-entry into the distal true lumen
■ POPLITEAL ARTERY
■ BTK ARTERIES
■ Standard approach
■ Subintimal recanalization
■ Retrograde approach
■ Retrograde tibial access
■ Hybrid tibial access
■ Pedal–plantar loop-technique
■ NITINOL STENTS
■ DRUG ELUTING STENTS (DES) FOR BELOW-THE-KNEE ARTERIES
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 19:
Outcomes of angioplasty and bypass in diabetes
■ INTRODUCTION
■ The natural history of PAD in patients with DFU
■ REVASCULARIZATION IN DIABETES WITH PAD
■ International variations, patient selection, and suitability for intervention
■ OUTCOMES OF REVASCULARIZATION
■ Perioperative complications and mortality
■ Patency rates
■ Wound healing, limb salvage, and amputation rate
■ Technical challenges
■ Revascularization in distal disease
■ SURGICAL BYPASS
■ The choice of conduit for bypass grafts
■ Prevention of graft occlusion
■ Vein graft surveillance
■ Outcomes in bypass surgery using synthetic grafts
■ Anastomotic modifications
■ ANGIOPLASTY
■ Subintimal versus transluminal angioplasty
■ The ‘angiosome model’
■ Stents and balloons (including drug-eluting stents)
■ ALTERNATIVE THERAPIES IN NONREVASCULARIZABLE DISEASE: CELL-BASED THERAPY
■ OTHER APPROACHES: PRE-EMPTIVE REVASCULARIZATION
■ VOLUME–OUTCOME RELATIONSHIP IN PERIPHERAL ARTERIAL SURGERY
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 4: NEUROPATHY
CHAPTER 20:
Pathobiology of neuropathy
■ INTRODUCTION
■ THE ANATOMY OF THE PERIPHERAL NERVOUS SYSTEM
■ Motor nerves
■ Sensory nerves
■ Autonomic nerves
■ TESTING FOR NEUROPATHY
■ THE CONSEQUENCES OF NERVE DAMAGE IN THE LOWER LIMBS AND FEET
■ Consequences of motor nerve dysfunction
■ Consequences of sensory nerve dysfunction
■ Consequences of autonomic nerve dysfunction
■ EPIDEMIOLOGY
■ DIFFERENTIAL DIAGNOSIS OF A DISTAL SYMMETRIC POLYNEUROPATHY
■ PATHOLOGICAL MECHANISMS
■ Aldose reductase and the polyol pathway (Figure 20.5)
■ Hypoxia
■ Hyperlipidemia
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 21:
The diagnosis and clinical impact of diabetic distal symmetrical polyneuropathy
■ INTRODUCTION
■ NEUROPATHIC SYMPTOMS
■ NEUROPATHY, MOBILITY, AND BALANCE
■ ALTERED BIOMECHANICS OF THE FOOT
■ NEUROPATHY AND PAD
■ NEUROPATHY AND TISSUE HOMEOSTASIS
■ DIAGNOSIS OF DSPN
■ MANAGEMENT OF DSPN
■ TREATMENT OF NEUROPATHIC PAIN
■ IMPROVING MOBILITY
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 22:
Surgical treatment of diabetic neuropathy
■ INTRODUCTION
■ CAN MEDICAL MANAGEMENT PREVENT NEUROPATHY?
■ A PROACTIVE SURGICAL APPROACH TO SYMPTOMATIC DPN
■ The nerve in diabetes is susceptible to compression
■ Additional critical studies related to neurolysis
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 5: WOUNDS AND ULCERATION
CHAPTER 23:
Acute and chronic wound healing biology in diabetes
■ INTRODUCTION
■ THE NORMAL WOUND HEALING PROCESS
■ Hemostasis
■ Inflammation
■ EARLY PHASE OF INFLAMMATION (DAYS 1–2)
■ LATE PHASE OF INFLAMMATION (DAYS 2–3)
■ Proliferation (from day 3)
■ Fibroblast migration
■ Formation of the extracellular matrix
■ Angiogenesis
■ Re-epithelialization
■ Wound contraction
■ Remodeling and scar maturation (week 1- beyond)
■ Transition from the acute to chronic diabetic foot wound
■ LOCAL FACTORS CONTRIBUTING TO PROGRESSION OF DFUS
■ Oxygenation
■ Infection
■ POTENTIAL SYSTEMIC FACTORS CONTRIBUTING TO THE PROGRESSION OF DFUS
■ Age
■ Stress/medications
■ Obesity and nutrition
■ Alcohol and smoking
■ MOLECULAR MECHANISMS ACCOUNTING FOR DFUS
■ Inflammation phase: alteration in growth factors and neuropeptides
■ Inflammation phase: nitric oxide
■ Inflammatory and proliferative phase: alteration in cell prolife
■ Proliferative phase: formation of the extracellular matrix
■ Inflammation and proliferation phase: mechanical damage and glycation
■ Decreased angiogenesis
■ Re-epithelialization
■ Vasculopathy
■ Neuropathy
■ MANAGEMENT STRATEGIES BASED ON MOLECULAR TARGETS
■ FUTURE DIRECTIONS
■ CONCLUSIONS
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 24:
Scoring systems and assessment of the ulcerated foot
■ INTRODUCTION
■ WHY CLASSIFY, SCORE, OR DESCRIBE?
■ Clinical care
■ Clinical research
■ Clinical audit
■ WHAT SHOULD BE CLASSIFIED OR SCORED? LESIONS, ULCERS, FEET, OR PEOPLE?
■ Multiple lesions
■ WHEN SHOULD CLASSIFICATION OR SCORING BE DONE?
■ Clinical care
■ Clinical research
■ Clinical audit
■ CLASSIFICATION OR SCORING?
■ Clinical care
■ Research and audit
■ DECIDING ON HOW AND WHAT TO SCORE
■ PUBLISHED CLASSIFICATION/SCORING SYSTEMS
■ The Meggitt–Wagner system
■ Knighton
■ Foster and Edmonds
■ University of Texas (UT) score
■ Van Acker/Peters
■ S(AD) SAD system
■ The SINBAD system
■ The PEDIS system
■ The DEPA system
■ DUSS
■ MAID
■ COMPARISONS OF CLASSIFICATION/SCORING SYSTEMS
■ SUMMARY
■ Clinical care
■ Clinical research
■ Clinical audit
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 25:
Wound dressings and debridement
■ INTRODUCTION
■ WOUND-HEALING AND WOUND-BED PREPARATION
■ Wound-healing process
■ Dressing development and the concept of moist wound healing
■ Wound bed preparation and TIME
■ DRESSING SELECTION
■ PROPERTIES OF THE IDEAL DRESSING
■ TYPES OF WOUND DRESSINGS
■ Debriding agents
Autolytic debridement
Biosurgical debridement
Hydrosurgery
Mechanical debridement
■ Low adherent dressings/wound contact layers
■ Semipermeable films
■ Hydrocolloids
■ Hydrogels
■ Alginates
■ Foam dressings
■ Antimicrobial dressings
■ BIOFILMS
■ TESTING
■ Advanced therapies
Protease modulating dressings
■ Wound diagnostics – point of care test
■ UNWANTED EFFECTS OF DRESSINGS
■ GROWTH FACTORS AND BIOENGINEERING
■ RESEARCH EVIDENCE FOR DRESSINGS FOR DFU
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 26:
Adjuncts to wound healing
■ INTRODUCTION
■ NEGATIVE PRESSURE WOUND THERAPY
■ EVIDENCE SUPPORTING THE USE OF NPWT
■ Health economics
■ Recommendations
■ Indications and contraindications
■ Complications
■ Practical considerations
■ HYPERBARIC OXYGEN THERAPY
■ EVIDENCE SUPPORTING THE USE OF HBO
■ Health economics
■ Recommendations
■ Indications and contraindications
■ Complications
■ Practical considerations
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 27:
Standardization of outcomes and end points of wound healing in everyday practice and clinical trials
■ INTRODUCTION
■ BACKGROUND, DEFINITIONS OF OUTCOME/END POINT, AND PRODUCING RECOMMENDATIONS
■ OUTCOMES USED IN WOUND HEALING STUDIES
■ BIASES THAT MAY INFLUENCE OUTCOME/END POINT EVALUATION OF STUDIES
■ RECOMMENDATIONS
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 6: SURGICAL INTERVENTION
CHAPTER 28:
Surgical anatomy of the foot
■ INTRODUCTION
■ OSTEOLOGY
■ Talus
■ Calcaneus
■ Cuboid
■ Navicular
■ Cuneiforms
■ Metatarsals
■ Phalanges
■ COLUMNS OF THE FOOT
■ JOINTS AND LIGAMENTS OF THE HINDFOOT
■ IMPORTANT JOINTS AND LIGAMENTS OF THE MIDFOOT AND FOREFOOT
■ ADAPTATION OF THE PLANTAR ASPECT OF THE FOOT TO WEIGHT BEARING
■ THE FOOT DURING AMBULATION AND PHASES OF GAIT
■ PLANTAR FASCIA
■ MUSCLES, TENDONS NERVES, ARTERIES, AND VEINS OF THE FOOT
■ Dorsum of the foot
■ Anterior ankle
■ Posterior to medial malleolus
■ Posterior ankle
■ Posterior to lateral malleolus
■ COMPARTMENTS OF THE FOOT
■ LAYERS OF THE PLANTAR ASPECT OF THE FOOT
■ The 1st layer
■ The 2nd layer
■ The 3rd layer
■ The 4th layer
CHAPTER 29:
Surgical debridement
■ INTRODUCTION
■ METHODS OF DEBRIDEMENT
■ TIMING
■ TECHNIQUE
■ Tourniquet
■ Debridement tools
■ CALLUS
■ SKIN
■ SUBCUTANEOUS TISSUE
■ FASCIA, MUSCLE, AND TENDON
■ BONE
■ Wound irrigation
■ Wound closure
■ SURGICAL DEBRIDEMENT IN CHRONIC WOUNDS
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 30:
Skin and local tissue flaps
■ INTRODUCTION
■ VASCULAR AND CUTANEOUS ANATOMY
■ PREPARATION FOR SPLIT-THICKNESS SKIN GRAFT OR LOCAL FLAPS
■ SPLIT-THICKNESS SKIN GRAFTS
■ LOCAL FLAPS
■ Rhomboid flap
■ Rotational flap
■ Bilobed flap
■ V-Y flap
■ Local axial flaps
■ SURGICAL OFF-LOADING OF EXTERNAL FIXATION FOR DIABETIC SOFT TISSUE RECONSTRUCTION
■ POSTOPERATIVE MANAGEMENT
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 31:
Free tissue transfer
■ INTRODUCTION
■ MULTIDISCIPLINARY APPROACH
■ Spectrum of care
■ Role of microsurgery
■ SURGICAL ALGORITHM
■ Debridement
■ Vascular intervention
■ SOFT TISSUE RECONSTRUCTION USING FREE FLAPS
■ RISK FACTORS
■ Selection of recipient vessels
■ Selection of flaps
■ Anterolateral thigh perforator
■ Superficial circumflex iliac artery perforator (SCIP)
■ OUTCOME AFTER FREE FLAP RECONSTRUCTION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 7: CHARCOT
CHAPTER 32:
The causes and diagnosis of acute Charcot foot in diabetes
■ DEFINITION
■ HISTORY
■ PRESENTATION
■ CAUSES
■ The role of inflammation
■ RANKL–NFκB
■ PREDISPOSITION TO THE DEVELOPMENT OF THE ACUTE CHARCOT FOOT
■ Neuropathy
Loss of protective sensation
Motor neuropathy
Vasomotor neuropathy
Neuropathy-induced arterial calcification and altered blood flow
Loss of neuropeptides
■ Genetic predisposition
■ Diabetes and the chronic inflammatory state
■ Nephropathy
Combined kidney pancreas transplantation
■ Other disease of the foot in diabetes
Pre-existing ulceration with or without osteomyelitis
■ Other complications of diabetes
■ INCOMPATIBILITY BETWEEN KNOWN CAUSATIVE FACTORS AND THE CLINICAL PRESENTATION
■ DIAGNOSIS OF THE ACUTE CHARCOT FOOT IN DIABETES
■ Clinical
■ Imaging
Plain X-ray
MRI
Computed tomography (CT)
PET and SPECT–CT
■ MONITORING DISEASE ACTIVITY AND THE DIAGNOSIS OF REMISSION
■ Difference in skin temperature between the two feet
■ Imaging
■ Venous sampling
■ OTHER OUTCOME MEASURES
■ Function
■ Radiology
■ Mortality
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 33:
Charcot osteoarthropathy: medical management and off-loading
■ INTRODUCTION
■ RATIONALE FOR IMMOBILIZATION AND OFF-LOADING
■ PUTATIVE MECHANISM OF ACTION OF OFF-LOADING AND IMMOBILIZATION
■ CRITERIA FOR IMMOBILIZATION AND OFF-LOADING
■ METHODS OF NONSURGICAL IMMOBILIZATION/OFF-LOADING
■ HOW CAN THE RESPONSE TO IMMOBILIZATION THERAPY BE MONITORED?
■ MEDICAL THERAPY
■ CLINICAL MANAGEMENT OF THE CHRONIC, QUIESCENT PHASE OF CO
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 34:
Charcot osteoarthropathy: surgical management and off-loading
■ INTRODUCTION
■ CLASSIFICATION REVIEW (TABLE 34.1)
■ SURGICAL INTERVENTION
■ SURGICAL APPROACH TO THE FOREFOOT/MIDFOOT
■ SURGICAL APPROACH TO THE HINDFOOT
■ SURGICAL APPROACH TO THE ANKLE
■ POSTOPERATIVE COMPLICATIONS
■ OFF-LOADING
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 8: AMPUTATION
CHAPTER 35:
Minor amputation and major amputation
■ INTRODUCTION
■ PREOPERATIVE PLANNING
■ INDICATIONS FOR AMPUTATION
■ LEVEL OF AMPUTATION
■ Toe amputation
■ Ray and transmetatarsal amputation
■ Midfoot and hindfoot amputation
■ Heel amputation
■ Syme's amputation
■ Below-knee amputation
■ Through-knee and Gritti–Stokes amputation
■ Above-knee amputation
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
CHAPTER 36:
Rehabilitation post-amputation
■ INTRODUCTION
■ Incidence, risk factors, and prevention of amputation
■ AMPUTATION OF THE FOOT
■ TRANSTIBIAL AMPUTATION
■ TRANSFEMORAL AMPUTATION
■ THROUGH HIP AND HINDQUARTER AMPUTATIONS
■ BILATERAL LOWER LIMB AMPUTEES
■ REHABILITATION PROGRAM AND MOBILITY OUTCOME
■ Phases of lower limb rehabilitation
Preamputation stage
Postamputation preprosthetic stage
Prosthetic gait training
Follow-up
■ Mobility and rehabilitation outcome
■ QOL OF PATIENTS WITH DIABETES AND AN AMPUTATION
■ REHABILITATION ISSUES IN AMPUTEES WITH DIABETES
■ Wound healing
■ RESIDUAL AND PLP
■ DEGENERATIVE ARTHRITIS
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
SECTION 9: BIOMECHANICS AND PREVENTION
CHAPTER 37:
Off-loading
■ INTRODUCTION
■ OFF-LOADING DEVICES
■ THE TOTAL CONTACT CAST
■ TCC MANUFACTURE
■ SURGICAL OFF-LOADING
■ CONCLUSION
■ AREAS OF CONTROVERSY AND/OR FUTURE RESEARCH
■ ACKNOWLEDGMENT
CHAPTER 38:
Prevention of ulcer recurrence
■ INTRODUCTION
■ EPIDEMIOLOGY AND RISK FACTORS
■ TREATMENT EFFICACY
■ Methods
■ Conservative treatment
■ Surgical off-loading
■ Clinical guideline recommendations
■ Conservative treatment
■ Surgical off-loading
■ FOOTWEAR QUALITY AND ADHERENCE
■ SUMMARY AND CONCLUSION
■ AREAS OF CONTROVERSY/FURTHER RESEARCH
CHAPTER 39:
Preventive foot care programs
■ INTRODUCTION AND EPIDEMIOLOGY
■ Whom to educate?
■ Who is responsible for the education of patients?
■ PATIENT EDUCATION ACCORDING TO RISK STRATIFICATION
■ DIABETES SELF-MANAGEMENT EDUCATION
■ Poor adherence to self-care education
■ OUTCOME OF STEP-BY-STEP FOOT PROJECT TARGETED HEALTH-CARE WORKERS
■ MULTIDISCIPLINARY TEAM APPROACH
■ Western perspective of diabetic foot care
■ Diabetic foot care in less-developed countries
■ CONCLUSION
■ ACKNOWLEDGEMENTS
INDEX
TOC
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