Editor JAMBUR ANANTH MD DPM Dip Psych (McGill) FRCP (Canada) FRCP (UK)
Professor of Psychiatry University of California,
Los Angeles, and
Director of Psychopharmacology Harbor UCLA Medical Center,
1000 West Carson Street Torrance CA 90509, USA
Jitendar P. Vij
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Psychopharmacology: Treatment of Psychiatric Disorders
© 1999, Jambur Ananth
All rights reserved. No part of this publication should be reproduced, stored in a retrieval system, or transmitted in any form or by any means: electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the editor and the publisher.
First Edition : 1999
Production Manager P. S. Ghuman
9788171796496
Typeset at JPBMP typesetting unit
Printed at Lordson Publishers (P) Ltd., C-5/19, R P Bagh, Delhi 110 007
To
my parents
my wife, Kamala Ananth
my son Kartik Ananth
and
all the volunteers who assisted in getting
the book ready for publication
5Preface
Psychopharmacology is a rapidly evolving science. Clinically pharmacological agents have helped many a suffering patients. The decade of the brain, the new knowledge in molecular biology and genetics have given new vistas for the development of this field. These rapid developments have increased the scope of psychopharmacology in understanding mental illness and manufacture medications which precisely improve the particular psychopathology. Their potentials have embraced the spectrum of personality disorder to the memory disorders.
A psychopharmacologist should be aware of the functions of the brain, understands the biological basis of various mental disorders, study the pharmacology of various psychoactive agents, and finally familiarizes himself with the treatment of these disorders.
With this broad scope, the book is written in four parts. The first part includes nerve transduction, dopaminergic serotonergic and norepinephrinergic system and pharmacokinetics. The second part deals with the pharmacology of various drugs. The third part explores the psychobiology of various mental disorders and the last part provides detailed information on the treatment of various mental disorders. Treatment of special populations are also included in the last part.
I am indebted to all the contributors and many others who helped me to put the material to the computer, assisted me in finding references and read the manuscript. My secretary Marylou Galano deserves special credit for her assistance.
Jambur Ananth
7Contributors
- Kotra Ajir md
- West Los Angeles VA Medical Center
- Medication Development Unit
- 10311 Wilshire Boulevard, Building 257
- Los Angeles, California 900073, USA
- Jambur Ananth md
- Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine, Harbor-UCLA Medical Center
- 1000 West Carson Street, Building 1-South
- Torrance, California 90509, USA
- Sudipto Chatterjee md
- Senior Resident
- Department of Psychiatry
- National Institute of Mental Health and Neurosciences
- PB 2900, Bangalore 560029, India
- Santosh Kumar Chaturvedi md
- Associate Professor of Psychiatry
- National Institute of Mental Health and Neurosciences, Bangalore 560029, India
- KN Roy Chengappa md
- Assistant Professor of Psychiatry
- Western Psychiatric Institute and Clinic
- 3811 O’Hara Street
- Pittsburgh, Pennsylvania 15213-2593 USA
- Christopher K Chung md
- Assistant Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine, Harbor-UCLA Medical Center
- 1000 West Carson Street, Building 1-South
- Torrance, California 90509-2910, USA
- John R DeQuardo md
- Department of Psychiatry
- University of Michigan Medical Center
- 1500 E Medical Center Drive
- Ann Arbor, Michigan 48109-0120, USA
- Mantosh Dewan md
- Vice-Chairman and Professor of Psychiatry
- SUNY Health Science Center at Syracuse
- 750 East Adams Street, Syracuse, New York 13210, USA
- Yogesh Dwivedi phd
- Professor of Psychiatry
- University of Illinois at Chicago
- The Psychiatric Institute (MC 912)
- 1601 West Taylor Street
- Chicago, Illinois 60612, USA
- Kishore M Gadde md
- Assistant Professor of Psychiatry
- Duke University Medical Center
- Durham, North Carolina 27710, USA
- Sanjay Gupta md
- Director of Psychiatry
- Olean General Hospital West
- 2221 West State Street
- Olean, New York 14760, USA
- Edward J Kim bs
- West Los Angeles VA Medical Center
- Medication Development Unit
- 10311 Wilshire Boulevard, Building 257
- Los Angeles, California 900073, USA
- K Ranga R Krishnan md
- Professor of Psychiatry
- Duke University Medical Center
- Durham, North Carolina 27710, USA
- Dilip V Jeste md
- Professor of Psychiatry and Neurosciences
- Director, Geriatric Psychiatry Clinical
- Research Center
- University of California, San Diego
- San Diego VA Medical Center (116A-1)
- 3350 La Jolla Village Drive
- San Diego, California 92161, USA
- Matcheri S Keshavan md
- Associate Professor of Psychiatry
- Western Psychiatric Institute and Clinic
- 3811 O’Hara Street
- Pittsburgh, Pennsylvania 15213-2593, USA
- Sumant Khanna md phd
- Associate Professor of Psychiatry
- National Institute of Mental Health and Neurosciences
- PB 2900, Bangalore 560029, India
- ME Kiely md
- Assistant Professor of Psychiatry
- Montreal General Hospital
- 1650 Cedar Avenue
- Montreal, Quebec, H3G 1A4, Canada
- Samarthji Lal md
- Professor of Psychiatry
- Montreal General Hospital
- 1650 Cedar Avenue, Montreal, Quebec
- H3G 1A4, Canada
- Ira Lesser md
- Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine
- Harbor-UCLA Medical Center
- 1000 West Carson Street, Building, D-5 Annex
- Torrance, California 90509, USA
- Lori Madmon ms
- Research Coordinator
- Eastside Comprehensive Med Services
- 133 East 73rd Street, Suite 209
- New York, 10021, USA
- David Mamo md
- Resident in Psychiatry
- Western Psychiatric Institute and Clinic
- 3811 O' Hara Street, Pittsburgh
- Pennsylvania 15213-2593, USA
- Prakash S Masand md
- Director, Psychiatric Consultation Service and Regional Psychopharmacology
- Consultation and Training Program
- Professor of Psychiatry, SUNY Health Science
- Center at Syracuse, 750 East Adams Street
- Syracuse, New York 13210, USA
- James T McCracken md
- Associate Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine, Neuropsychiatric Institute
- Room 48-270, 760 Westwood Plaza
- Los Angeles, Calfornia 90024, USA
- Ghanshyam N Pandey phd
- Professor of Pharmacology in Psychiatry
- University of Illinois at Chicago
- The Psychiatric Institute (MC 912)
- 1601 West Taylor Street, Chicago, Illinois 60612, USA
- Anand K Pandurangi md
- Professor of Psychiatry and Radiology
- Medical College of Virginia
- North Hospital, 1300 E. Marshall Street
- PO Box 980710, Richmond, Virginia 23298-0710, USA
- Russell E Poland phd
- Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine, Harbor-UCLA Medical Center
- 1000 West Carson Street, Building F-5
- Torrance, California 90509, USA
- Uma Rao md
- Assistant Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine
- Neuropsychiatric Institute
- Room 68-237, 760 Westwood Plaza
- Los Angeles, California 90024, USA
- Janardhan Reddy YC
- Assistant Professor of Psychiatry
- National Institute of Mental Health and Neurosciences
- PB 2900, Bangalore 560029, India
- Andres Sciolla md
- Professor of Psychiatry and Neurosciences
- Director
- Geriatric Psychiatry Clinical Research Center
- University of California, San Diego
- San Diego VA Medical Center (116A-1)
- La Jolla Village Drive
- San Diego, California 92161, USA
- Ram K Shrivastava md
- Research Director
- Eastside Comprehensive Med Sciences
- 133 East 73rd Street, Suite 209
- New York, 10021, USA
- Michael Smith md
- Assistant Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine
- Harbor-UCLA Medical Center
- 1000 West Carson Street, Building D-5
- Torrance, California 90509, USA
- J Randolph Swartz md
- Assistant Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine
- Harbor-UCLA Medical Center
- 1000 West Carson Street, Building 1-South
- Torrance, California 90509, USA
- Stephan F Taylor md
- Department of Psychiatry
- University of Michigan Medical Center
- 1500 E Medical Center Drive
- Ann Arbor, Michigan 48109-0120, USA
- Mauricio Tohen md
- Associate Professor of Psychiatry
- Indiana University
- Medical Advisor
- Lilly Research Laboratories
- Eli Lilly and Company
- Lilly Corporate Center
- Indianapolis, Indiana 46285, USA
- A Venkoba Rao md phd
- Emeritus Professor of Psychiatry
- Madurai Medical College
- Madurai 625020, India
- Carlos A Zarate Jr. md
- Director of Bipolar and Psychotic Disorders
- McLean Hospital
- Assistant Professor of Psychiatry
- Harvard Medical School
- 115 Mill Street
- Belmont, Massachusetts 02178, USA
- Karl S Burgoyne md
- Department of Psychiatry
- Harbor-UCLA Medical Center
- 1000 West Carson Street, Building D-5
- Torrance, California 90509, USA
- Karen M. Johnson md
- Assistant Professor
- Department of Psychiatry and Behavioral Sciences
- UCLA School of Medicine
- Harbor-UCLA Medical Center
- 1000 West Carson Street, Building 1-South
- Torrance, California 90509, USA
- Rajiv Tandon md
- Schizophrenia Program
- University of Michigan Medical Center
- 1500 E. Medical Center Drive
- Ann Arbor, Michigan 48109-0120, USA