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Critical Care Update 2004
Vineet Nayyar
SECTION A: EDUCATION & TRAINING IN CRITICAL CARE
ONE:
Critical Care Education in India: Well Begun is Half Done
INTRODUCTION
GOALS
ENTRY REQUIREMENTS AND CURRICULUM
TRAINING SITES AND INSTRUCTORS
FINAL ASSESSMENT OF CANDIDATES
LIMITATIONS TO CRITICAL CARE EDUCATION IN INDIA
WELL BEGUN IS HALF DONE
TWO:
Web-based Resources for Critical Care Education
INTRODUCTION
JOURNALS
Online Version of Printed Journals
Critical Care Medicine
Intensive and Critical Care Medicine
Critical Care Nurse
British Medical Journal: Intensive Care
Critical Care Forum
Respiratory Care
New England Journal of Medicine (NEJM)
British Medical Journal (BMJ)
The Lancet
Journal of Indian Society of Critical Care Medicine
Internet Journals (Virtual)
The Internet Journal of Emergency and Intensive Care Medicine
Search Tools
National Library Medicine, MEDLINE
Ovid Medline
Google Search Tool
ONLINE BOOKS FOR THE INTENSIVIST
CRITICAL CARE CASES
MEDICAL LECTURES
ONLINE MEDICAL EVENTS
Critical Care Conferences on the Internet
The First International Congress on Critical Care Medicine in Internet
DISCUSSION GROUPS
CRITICAL CARE WEBSITES
MEDICAL SOFTWARE FOR THE INTENSIVIST
PC Based Software
PedsCCM Software (http://pedsccm.wustl.edu/CLINICAL/Software.html)
Anesoft (http://www.anesoft.com/)
Madscientist.com (http://www.madsci.com/)
Sofotex Medical Software (http://www.sofotex.com/download/Medical_Software/)
Hypertox (http://members.ozemail.com.au/~ouad/index.html)
Medismart (http://medi-smart.com/tutorials.html)
Hemodynamic Simulator and Guide (http://www.manbit.com)
ACLS-Stat (http://www.skillstat.com/ACLS_STAT_demo.html)
PDA
Medical Calculators
Scoring systems for ICU and Surgical Patients (http://www.sfar.org/s/article.php3?id_article=60):
General Adult Scoring Systems
Specialized Adult Scoring Systems
Pediatric General Scoring Systems
Pediatric Specialized Scoring Systems
National Center for Emergency Medicine Informatics (http://www.ncemi.org)
MedCalc 3000 (http://medcalc3000.com/)
PROTOCOLS AND GUIDELINES
CRITICAL CARE SOCIETIES/ORGANIZATIONS
FUTURE VISION
THREE:
Simulation-based Education in Critical Care
INTRODUCTION
EDUCATION THEORY
WHAT IS SIMULATION?
WHY SIMULATION IN CRITICAL CARE?
SIMULATION: TYPES AND VARIETY
High Level Simulator
Simulation-based Education
JUSTIFICATION
DRAWBACKS
CONCLUSIONS
SECTION B: RENAL PROBLEMS IN ICU
FOUR:
Acute Renal Failure—Failure of the Kidneys and of Definitions
INTRODUCTION
ARF—FAILURE OF DEFINITIONS
Definitions of ARF—Challenges
Definitions of ARF—Limitations
ARF—FAILURE OF KIDNEYS
BUN and Serum Creatinine
Urine Output
Creatinine Clearance (CrCl)
Markers of Renal Tubular Injury
Patients with Unknown Baseline Renal Function
Acute on Chronic Renal Failure
RECENT DEVELOPMENTS—RIFLE CRITERIA
Validation of New Definitions
CONCLUSIONS
FIVE:
Renal Protective Strategies in Acute Renal Failure
INTRODUCTION
ACUTE TUBULAR NECROSIS PRESENTING AS ARF
Clinical Course of ATN
Preventative Strategies
Therapy
RADIOCONTRAST INDUCED ARF
Hydration
N-acetylcysteine
NEPHROTOXIC DRUG INDUCED ARF
Management
OTHER CAUSES OF ARF
Therapy
CONCLUSION
SIX:
Diuretics in Acute Renal Failure: Have Recent Studies Broken New Ground?
INTRODUCTION
RATIONALE FOR THE USE OF DIURETICS
WHAT WAS THE PREVAILING VIEW IN THE LITERATURE OF THE PAST?
WHAT DO THE RECENT STUDIES SHOW?
DISCUSSION
CONCLUSION
SEVEN:
Does Aggressive Intermittent Hemodialysis Measure up to Continuous Renal Replacement Therapy (CRRT)?
INTRODUCTION
TECHNIQUE CHARACTERISTICS
Potential Advantages of CRRT over Intermittent Hemodialysis Techniques
Potential Disadvantages of CRRT Compared with IHD
THERAPY COMPARISONS: WHAT ARE THE DATA?
Effect on Survival
Dose Outcome Relationships
Cost
Procedure-related Complications
WHICH MODALITY SHOULD BE USED?
SUMMARY
SECTION C: CARDIOVASCULAR PROBLEMS IN ICU
EIGHT:
Cardiogenic Shock: Revisited
INTRODUCTION
CLINICAL PRESENTATION
PATHOPHYSIOLOGY
B-TYPE NATRIURETIC PEPTIDE—AN EMERGING TOOL
INITIAL MANAGEMENT
Airway Management
Morphine
Diuretic Treatment
USE OF VASOACTIVE AGENTS
Inotropes
Nitroglycerin
Nesiritide
Sublingual Captopril
REVASCULARIZATION AND MECHANICAL SUPPORT
Percutaneous Coronary Intervention (PCI)
The Intra-aortic Balloon Pump (IABP)
Ventricular Assist Devices (VAD)
FUTURE DIRECTIONS
ISSUES IN MANAGEMENT OF CARDIOGENIC SHOCK
How Should the Elderly be Treated?
Is There a Therapeutic Window for Emergency Revascularisation?
What is the Quality of Life?
CONCLUSION
NINE:
Is It Time to Bid Farewell to the Pulmonary Artery Catheter?
INTRODUCTION
HISTORICAL EVIDENCE IN SUPPORT OF PAC USE IN CRITICAL CARE
HISTORICAL EVIDENCE AGAINST PAC USE IN CRITICAL CARE
WHAT IS THE CURRENT BEST EVIDENCE FOR OR AGAINST PAC?
HOW AND WHY DID WE GET TO THIS STAGE?
AND WHERE DO WE GO FROM HERE?
CONCLUDING REMARKS
TEN:
Preventing Myocardial Ischemia in the ICU
INTRODUCTION
PATHOPHYSIOLOGY
PREOPERATIVE RISK STRATIFICATION
Pre-existing Heart Disease
Hypertension
Left Ventricular Dysfunction
PERIOPERATIVE PATIENT MANAGEMENT
Beta-Blockers
Alpha-2 Agonists
Other Factors
Trends
TYPE OF ANAESTHESIA
Epidural or General Anaesthesia
POSTOPERATIVE CARE
Pain Control
Glycemic Control
Glycemic Control in the Diabetic
CONCLUSION
ELEVEN:
Intravenous Magnesium in Cardiac Arrhythmias
INTRODUCTION
POSSIBLE MECHANISMS OF ANTIARRHYTHMIC EFFECTS
ROLE OF MAGNESIUM IN SPECIFIC ARRHYTHMIAS
Torsades de Pointes (TdP)
Digoxin Induced Ventricular Tachyarrhythmias
Multifocal Atrial Tachycardia (MAT)
Supraventricular Tachycardias (SVT)
Atrial Fibrillation (AF)
Monomorphic Ventricular Tachycardia (VT)
ROLE OF MAGNESIUM IN OTHER CARDIOVASCULAR CONDITIONS
Magnesium and Cardiac Surgery
Acute Myocardial Infarction (AMI)
Cardiac Arrest
MAGNESIUM AS THERAPY
Guidelines for Administration
CONCLUSION
SECTION D: TRAUMA/NEUROCRITICAL CARE
TWELVE:
Are We Ready for Hypertonic Saline in Brain Injury?
INTRODUCTION
MECHANISM OF ACTION
Osmotic Effect
Improvement of Cerebral Blood Flow
Other Mechanisms
EXPERIMENTAL USE OF HTS FOR RAISED ICP
PHARMACOKINETICS AND SYSTEMIC EFFECTS IN HUMANS
HEAD INJURY AND HYPOTENSION: RESUSCITATION WITH HTS
HEAD INJURY AND HIGH ICP: CONTROL OF RAISED ICP WITH HTS
Comparison with Mannitol
HTS AND OTHER NEUROLOGICAL DISORDERS
COMPLICATIONS OF HYPERTONIC SALINE INFUSION
CONCLUSIONS
THIRTEEN:
Should Intracranial Pressure be Routinely Monitored in Patients with Head Injury?
INTRODUCTION
ICP DATA AND CLINICAL DECISION MAKING
CURRENT PRACTICES OF ICP MONITORING IN HEAD INJURY
SHOULD ICP BE MONITORED IN ALL PATIENTS WITH TBI?
Patients at High Risk of Raised ICP after TBI
Influence of ICP Monitoring on Patient Management
Effect of ICP Monitoring on Outcome
Evidence in Support of ICP Monitoring
Evidence Against Benefits of ICP Monitoring
RECOMMENDATIONS OF THE BRAIN TRAUMA FOUNDATION
The Cochrane Database Review
The Impact of the BTF Recommendations
THE SCOPE FOR A RANDOMISED TRIAL
FUTURE TRENDS
Advanced ICP Waveform Analysis
Noninvasive Alternatives for Assessment of ICP
Repeated CT Scanning as an Alternative to ICP Monitoring
SUMMARY
FOURTEEN:
Decompressive Craniectomy for Severe Traumatic Brain Injury
INTRODUCTION
PATHOPHYSIOLOGY
DECOMPRESSIVE CRANIECTOMY
MERITS OF DEC
Improved Outcome
Control of ICP
CT Scan Appearance
SURGICAL PROCEDURE
Timing of Surgery
Surgical Decompression
Postoperative Complications
CONCERNS RELATED TO DEC
FUTURE DIRECTIONS
FIFTEEN:
Alternate Techniques for Diagnosing Brain Death
INTRODUCTION
THE DEFINITION OF BRAIN DEATH
TRANSCRANIAL DOPPLER (TCD)
EEG
EVOKED POTENTIALS
CEREBRAL ANGIOGRAPHY
RADIONUCLIDE SCINTIGRAPHY
MAGNETIC RESONANCE IMAGING (MRI) AND CT ANGIOGRAPHY
CONCLUSION
SECTION E: TOXICOLOGY
SIXTEEN:
Role of Oximes in Human Organophosphate Poisoning—A Critical Look at the Evidence
INTRODUCTION
METHODOLOGY
RESULTS
DISCUSSION
Nature of the Organophosphate Compound
Dosage of the Antidote
Poison Load
Pharmacokinetics and Pharmacodynamics
Time of Administration of the Antidote
Ageing of the Organophosphate Compound
Toxicity of the Antidote
CONCLUSIONS
ACKNOWLEDGEMENTS
SEVENTEEN:
Aluminium Phosphide Poisoning—A Review
INTRODUCTION
CHEMICAL PROPERTIES
KINETICS AND TOXICITY
WHAT DO WE KNOW ABOUT THE MECHANISM OF ACTION
RANGE OF TOXICITY
CLINICAL AND PATHOLOGICAL MANIFESTATIONS
Gastrointestinal Symptoms
Cardiovascular Signs
Shock and Multiorgan Failure
MANAGEMENT
PREVENTIVE MEASURES
EIGHTEEN:
Rodenticides
INTRODUCTION
AN APPROACH TO IDENTIFICATION OF RAT POISON
PRELIMINARY CARE
Decontamination
Toxicological Analysis
Range of Toxicity
CLINICAL MANIFESTATIONS OF COMMON RODENTICIDES
Anticoagulants
Metal Phosphides
Yellow Phosphorus
Thallium Sulfate
Convulsants
SPECIFIC ANTIDOTES AND MANAGEMENT
Anticoagulants
Metal Phosphides
Yellow Phosphorus
Thallium
Convulsants
CONCLUSIONS
ACKNOWLEDGEMENTS
NINETEEN:
Yellow Oleander Poisoning
INTRODUCTION
Epidemiology
Biology
MECHANISMS OF TOXICITY
Cardenolides in General
Effects of Yellow Oleander Cardenolides
PHARMACOKINETICS AND PHARMACODYNAMICS
Pharmacokinetics
Pharmacodynamics
CLINICAL FEATURES
Electrocardiography
OUTCOMES
RANGE OF TOXICITY
INVESTIGATIONS
Biochemistry
Digoxin Assay
MANAGEMENT
Monitoring
Reversing Bradycardia
SPECIFIC THERAPY
Anti-digoxin Fab Antitoxin
Temporary Cardiac Pacing
Anti-arrhythmic Drugs
Correction of Electrolytes
Magnesium Sulphate
Electrical Cardioversion
Future Therapy
ACKNOWLEDGEMENTS
INDEX
TOC
Index
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