Gynecological Endoscopy and Infertility Gautam N Allahbadia, Rubina Merchant, Hugo C Verhoeven, Rudy Leon De Wilde
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1Gynecological Endoscopy and Infertility2
3Gynecological Endoscopy and Infertility
Editors Gautam N Allahbadia MD DNB FNAMS Consultant Fertility Physician Dr LH Hiranandani Center for Human Reproduction Dr LH Hiranandani Hospital, Powai Mumbai, India Director IVF The Prince Aly Khan Center for Human Reproduction The Prince Aly Khan Hospital, Mazgaon Mumbai, India Medical Director Rotunda - The Center for Human Reproduction Bandra, Mumbai, India Rubina Merchant PhD Embryologist Rotunda - The Center for Human Reproduction Bandra, Mumbai, India Associate Editors Hugo C Verhoeven MD Medical Director and Senior Partner The Center for Reproductive Medicine Endocrinology, Genetics and Antiaging Medicine Dusseldorf, Germany Rudy Leon De Wilde MD ScD PhD Professor and Head of the Department Pius Clinic Oldenburg, Germany
4Published by
Jitendar P Vij
Jaypee Brothers Medical Publishers (P) Ltd
EMCA House, 23/23B Ansari Road, Daryaganj
New Delhi 110 002, India
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Branches
Gynecological Endoscopy and Infertility
© 2005, Gautam N Allahbadia, Rubina Merchant
All rights reserved. No part of this publication should be reproduced, stored in a retrieval system, or transmitted in any form or by any means: electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the editors and the publisher.
First Edition: 2005
9788180615061
Typeset at JPBMP typesetting unit
Printed at Gopsons Papers Ltd., A 14, Sector 60, Noida5
“When I find myself fading, I close my eyes and realize my friends are my energy.” —Anon
This book is dedicated to all our Friends6
7Foreword
There have been numerous books written on the subject of infertility and its treatment over the last few years. However, the majority of them are only suitable for a limited audience. For example, some books contain much scientific material but lack any information on the clinical applications. The more clinically orientated volumes tend to fall into two distinct groups: they are either so detailed and complex that only a subspecialist in reproductive medicine will appreciate the content or alternatively, so simplistic that it becomes difficult to take them seriously because even essential details are omitted. The present volume goes a long way to bridging this gap in the available literature on fertility and its treatment, which makes it very different from the other books in the market. The clinical and scientific contents of the book are divided into four easy-to-read sections which deal in turn with the important issues of:
Infertility Diagnosis and Management, Assisted Reproductive Techniques, Fertility Enhancing Endoscopic Procedures and Future Challenges in the Field of Infertility Treatment.
Throughout, the authors have adopted a clear and comprehensive style, providing the reader with sufficient factual information to further their understanding of the clinical problems under consideration. At the same time, much of the text is orientated towards helping the busy clinician acquire practical knowledge and skills. The general text on infertility is a suitable reference source for primary care physicians, nurses, ultrasonographers, embryologists, andrologists, counsellors and health psychologists who are involved in the care of couples with infertility. For both the established gynaecologists and those medical and nursing reproductive medicine specialists in training, this book offers a comprehensive source of up-to-date information on infertility and its management. Various professionals, such as clinicians and nurses will find this a suitable general text on infertility.
As such, this book will undoubtedly appeal to a large and varied cross section of professionals in the field of reproductive medicine and ideally, should be included in the library of everyone involved in providing infertility services. Ultimately, it should be the couple seeking solutions to their problem, and the work is written in a manner that allows even laypersons to gain some understanding of what is happening to them.
Assisted Reproductive Techniques have become well-established set of infertility treatment methods, which have helped hundreds of thousands of infertile couples worldwide. During this journey, several important milestones have been passed, for example, cryopreservation of human embryos, oocyte donation, pre-implantation genetic diagnosis, intracytoplasmic sperm injection and others. The field of ART continues to evolve at a rapid pace. Practitioners and investigators in the field continue to search for, develop, and implement innovations in an effort to address shortcomings in the efficacy of the technology. This book has addressed issues in ART that have never been included in subject textbooks before, like the chapter on Embryo Donation. Issues that clearly reflect the areas of potential improvement that might be translated into improved patient outcomes have been included in the section on ART. The overall objective of the ART section is to explore current knowledge about how factors related to the oocyte, the embryo, and the endometrium can be applied to improve outcomes in ART.
Since the introduction of Endoscopy by Jacobaeus in 1910, there has been a dramatic change in the pattern of and approach to the diagnosis and treatment of various diseases of the female reproductive 8organs. The advances in techniques of operative Endoscopy, in high technology and in instrumentation (such as endoscopes, video cameras and videomonitors) have made it possible to perform laparoscopically many of the infertility-related procedures previously requiring laparotomy. Every aspect of fertility enhancing hysteroscopic and laparoscopic surgery has been dealt with in the section on Endoscopy in Infertility.
The last section on “Future Challenges” has truly thought provoking topics, which have been discussed thoroughly including the scourge of the developing world—genital tuberculosis as well as human cloning. For hundreds of years, the medical world has dreamed of being able to repair, piece by piece, any ailing or worn-out part of the human body. This science began with organ transplants to xenotransplantation and is moving towards cell therapy. Cell therapy is today widely used for blood disorders (transplantation of blood-forming stem cells) and burns (skin grafts), and experiments are currently being carried out involving transplants of liver cells to treat liver diseases, endocrine pancreatic cells to treat diabetes and neural stem cells to treat various neuro-degenerative disorders. I hope that this volume will stimulate the readers to think more about these profound and sensitive ethical issues.
Professor Lesley Regan
Professor and Head of Department
Obstetrics and Gynaecology
Imperial College at St Mary's Hospital, London, UK
Honorary Consultant
Obstetrics and Gynecology
St Mary's NHS Trust
Service Director Gynaecology
Women and Children's Directorate
St Mary's Hospital NHS Trust
Programme Director
Subspeciality Training in Reproductive Medicine at
St Mary's and Hammersmith Hospital Trusts
Deputy Head
Division Paediatrics Obstetrics and Gynaecology
Imperial College, London
9Preface
The marvels of electronic and information technology have strengthened the biochemical and molecular power of diagnosis and the surgical and medical management of infertility, transforming the very practice of medical science into a reality that could barely be envisaged two decades ago. We now enter the age of Robotics, Telesurgery, and Therapeutic Cloning. This dynamic process of reform continues to deliver practitioners with information, ideas and tools that spell answers to some of the most pressing dilemmas in infertility management. Infertile couples represent a psychologically and emotionally fragile segment of society with a mission to succeed that places treating physicians under great stress to produce the desired results. Nevertheless, are we professionally, technically, morally and ethically aware and committed enough to deliver the expertise and knowledge that we have promised our patients and ourselves?
This book was conceived to discuss the current techniques in Gynecological Endoscopy, Infertility and ART, the validity and effectiveness of the approach, the lessons learnt in the past, and the future challenges that are posed before us. It aims to familiarize clinicians, surgeons, researchers, students, and patients alike with the undaunted innovations in medical technology, expose the grey areas of management in the various allied fields of reproductive medicine, and present solutions to the various medical and surgical challenges, thus helping them to fit the pieces together and focus and rationalize thinking to achieve a positive outcome. The interrogative design of the carefully thought of chapters, distributed in four sections, churns out answers to ‘why we do what we do, how we do it, when should we do it, and are we on the right track?’ engaging the contributor and the reader in a process of constructive self-evaluation. By offering a comprehensive and panoramic view of the areas most crucial to the management and treatment of infertility—Gynecological Endoscopy, Medical and Surgical therapy for Infertility and Assisted Reproduction, it serves to complete the missing links in the thought process in a single edition, bridge the misinformation gap, and unite the medical fraternity in a common belief and motive.
We appreciate the finesse and intellectual skill with which the contributors have presented information pertinent to their chapters and thank them for sharing their uniquely invaluable experiences with the reader. We sincerely do hope that we have succeeded in our effort to disseminate the necessary knowledge required to practice evidence-based reproductive medicine that is safe, productive, cost-effective, morally and ethically acceptable in the best interests of desirous couples and humanity as a whole.
Gautam N Allahbadia
md dnb fnams
Rubina Merchant
phd
Hugo C Verhoeven
md
Rudi Leon De Wilde
md
10
11List of Contributors