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Surgery–10
Roshan Lall Gupta
1:
Glimpses of Progress in Surgery
STEM CELL RESEARCH
Embryonic Stem Cells
Adult Stem Cells
Cardiac Regeneration with Adult Stem Cells
Stem Cells and Brain Repair
Other Sources for Stem Cells
Problems with the Therapeutic Use of Stem Cell
REFERENCES
NON-HEARTBEATING KIDNEY DONORS
REFERENCES
LIVE DONOR LIVER TRANSPLANTATION
REFERENCES
EVIDENCE-BASED SURGERY
REFERENCES
ROBOTICS IN SURGERY
REFERENCES
SURGERY FOR CONJOINED TWINS
REFERENCES
SURGERY FOR FACIAL PALSY
REFERENCE
REFERENCE
REFERENCE
CHEMOPREVENTION OF CANCER
Role of Certain Natural Products
REFERENCES
TREATMENT OF ANEMIA FOR PATIENTS RECEIVING RADIOTHERAPY
REFERENCES
POSITRON EMISSION TOMOGRAPHY (PET)
Cancer Imaging of The Future
REFERENCES
PET SCAN IN CARCINOMA ESOPHAGUS
REFERENCES
HEPATIC IMAGING
REFERENCES
CANCER ESOPHAGUS – SINGLE CENTER EXPERIENCE
REFERENCES
CYFRA 21-1: A SENSITIVE TUMOR MARKER FOR ESOPHAGEAL SQUAMOUS CELL CANCER
REFERENCES
FINE NEEDLE ASPIRATION BIOPSY OF NECK LUMPS
REFERENCES
SENTINEL NODE BIOPSY IN OPERABLE BREAST CANCER
REFERENCES
MULTIPLE MYELOMA—THALIDOMIDE-DEXAMETHASONE AS A PRIMARY THERAPY
REFERENCES
GASTRIC CARCINOIDS
REFERENCES
ASYMPTOMATIC GALLSTONES
REFERENCE
MIRIZZI SYNDROME—A DIAGNOSTIC AND OPERATIVE CHALLENGE
REFERENCES
EARLY POSTOPERATIVE SMALL BOWEL OBSTRUCTION
REFERENCES
PRIMARY HYPERPARATHYROIDISM
REFERENCES
THYROID EYE DISEASE
REFERENCES
SURGICAL CARE PRACTITIONERS
REFERENCES
SURGICAL TRAINING IN THE UK
REFERENCE
INTERNATIONAL PROSTATE SYMPTOM SCORE (IPSS): ITS ROLE IN PREDICTING POSTOPERATIVE ACUTE URINARY RETENTION IN MALE PATIENTS UNDERGOING MAJOR SURGERY
REFERENCE
MANNED MISSION TO MARS
REFERENCES
SARS AND THE BIRD FLU
REFERENCES
CREUTZFELDT-JAKOB DISEASE (CJD)
REFERENCE
2:
Evidence-based Surgery
INTRODUCTION
ACUTE ABDOMEN
Pain
INTESTINAL OBSTRUCTION
APPENDICITIS
What is not Appendicitis?
GALLSTONES
CBD Stones
Silent Gallstones
Symptomatic Stones
ACUTE CHOLECYSTITIS
ERCP
Lapchole
Sphincterotomy
BILE DUCT INJURIES
ACUTE PANCREATITIS
Treatment After the Attack of Acute Pancreatitis Settles Down
Gallstone Pancreatitis
Alcoholic Pancreatitis
When the Attack of Acute Pancreatitis does not Settle Down
Role of Surgery?
Sterile Necrosis
PANCREATIC CYSTS
Infected Pseudocysts
CHRONIC PANCREATITIS
PANCREATIC CANCER
HERNIA
CONCLUSION
FUTURE
3:
Multidisciplinary Therapy in Cancer
INTRODUCTION
THE BIOLOGIC BASIS OF MULTIMODALITY THERAPY
THERAPEUTIC BASIS OF MULTIMODALITY THERAPY
Surgery
Radiotherapy
Chemotherapy
Other Therapies
Chemotherapy and Radiation
Surgery and Radiation
Chemotherapy
Combination of Surgery, CT and RT*
Results of Multimodality Therapy
Multimodality Approach to Early Disease
APPROACH TO ADVANCED AND METASTATIC DISEASE
COMPONENTS OF THE MULTIDISCIPLINARY ONCOLOGY TEAM
The Surgeon Oncologist
The Medical Oncologist
The Radiation Oncologist
Nononcologist Specialists
Nonmedical Team
Palliative Care and Hospice
MULTIDISCIPLINARY APPROACH AND CLINICAL TRIALS
MULTIDISCIPLINARY THERAPY OF INDIVIDUAL CANCERS—SOME EXAMPLES
Anal Cancer-Organ Conservation
Testicular Germ Cell Tumor—Cure
Breast Cancer—More ‘Radical’ to Less ‘Radical’
4:
Recent Advances in Control and Prophylaxis of Surgical Infections
INTRODUCTION
CRITERIA FOR DEFINING SSIs AS PER CDC2
MICROBIOLOGY AND ETIOPATHOGENESIS OF SSIs
Acute Soft Tissue Infection
Wound-sampling Method
Wound Tissue-Sampling
Wound Fluid-Sampling
Specimen Transport
DEFINITIVE ANTIMICROBIAL THERAPY
RISK FACTORS AND PREVENTION OF SURGICAL SITE INFECTIONS (SSI)
Patient Characteristics
Preoperative Characteristics
Patient-Related
Surgical Team-related
Operation-related Issues
Operating Room Environment
Surgical Attire and Drapes
Asepsis and Surgical Technique
Postoperative Issues
Incision Care
Discharge Planning
ROLE OF ENVIRONMENT/AIR IN DAY-TO-DAY SURGERY
Heating Ventilation Air-Conditioning System (HVAC)
Air-Filtration Systems for Operating Rooms
Additional Filtration System
HEPA Filters
Laminar Air-Flow Air-Ventilation System
UV Germicidal Irradiation (UVGI)
Standards for Air-borne Contamination14
Conventional Ventilation
Ultraclean Laminar-Flow Theaters
Direction of Air-Flow
Performance Monitoring and Assessment
Microbiological Sampling
STERILIZATION AND DISINFECTION OF DEVICES USED ON PATIENTS
Sterility Assurance Level
Indicators
Exposure Control
Load Control
Inside Pack Control
Flash Sterilization
After Steam and Ethylene Oxide (ETO) Rapid Readout
Rational Approach to Disinfection and Sterilization
Heat Sterilization
Ionizing Radiation
Chemical Methods
ISSUES IN CSSD: SHELF-LIFE OF CSSD MATERIAL FOR USE IN HOSPITAL
Event-related Sterility
Time-related Sterility
STERILIZATION/DISINFECTION OF ENDOSCOPES
Features to Consider When Purchasing a Machine
Cleaning and Disinfection—Practical Recommendations
At the Start of the Day
Cleaning and Disinfection of Endoscopes Between Cases
Cleaning and Disinfection of Copes After the Last Case
Cleaning and Disinfection of Accessories
Disinfectants Used for Endoscopes
Orthophthalaldehyde (OPA)
Formalin Cabinets
Hydrogen Peroxide Gas Plasma Method
ANTIMICROBIAL PROPHYLAXIS
CONCLUSION
5:
Medical Informatics
INTRODUCTION
HOSPITAL INFORMATION SYSTEM (HIS)
COMPUTERS IN HEALTH EDUCATION
TELEMEDICINE
TECHNOLOGY AND FINANCE
ELECTRONIC MEDICAL RECORD (EMR)
Medical Records
Evolution of Medical Records
Computerization of the Medical Record
WANs, LANs and WLANs7
Creating a Wireless Network
Security Issues
Hand-Held Mobile Computers (Personal Digital Assistants)9
CONCLUSION
REFERENCES
FURTHER READING
6:
Fetal Surgery
INTRODUCTION
SELECTION CRITERIA
MATERNAL-FETAL RISKS
FETAL SURGICAL TECHNIQUES
Open Fetal Surgery
Minimal Access Fetal Surgery-FETENDO
FETAL MALFORMATIONS AMENABLE TO SURGICAL CORRECTION
Congenital Diaphragmatic Hernia (CDH)
Obstructive Uropathy (Posterior Urethral Valves)
Congenital Cystic Adenomatoid Malformation
Sacrococcygeal Teratoma
Twin-to-Twin Transfusion Syndrome
Myelomeningocele
Congenital High Airway Obstruction Syndrome
Amniotic Band Syndrome
Fetal Plastic Surgery
Rationale for Fetal Plastic Surgery
FUTURE OF FETAL SURGERY
FETAL ENGINEERING RESEARCH
7:
Bariatric Surgery
INTRODUCTION
OBESITY AND ITS SIDE EFFECTS
Morbidity of Obesity (Table 7.2)
MANAGEMENT OF MORBID OBESITY
Multidisciplinary Approach
Indications for Bariatric Surgery
History of Bariatric Surgery
BARIATRIC PROCEDURES
Restrictive Procedures
Laparoscopic Adjustable Gastric Banding (LAGS)
Vertical Banded Gastroplasty
Combined Procedures
Roux-en-Y Gastric Bypass (RYGBP)
Malabsorptive Procedures
Biliopancreatic Diversion (BPD)
NEWER PROCEDURES
IMPROVEMENT IN CO-MORBIDITIES
CONCLUSION
ACKNOWLEDGMENTS
8:
Common Inguinoscrotal Problems in Children
INTRODUCTION
INDIRECT INGUINAL HERNIA
Diagnosis
Treatment
Inguinal Approach
Preperitoneal Approach
Irreducible Hernia
Postoperative Complications
HYDROCELE
UNDESCENDED TESTIS (UDT) CRYPTORCHIDISM
Embryology
Sequelae of Nondescent
Histological Changes
Treatment
Methods of Orchiopexy
Role of Hormones
Laparoscopy
Complications of Orchiopexy
Indications for Orchiectomy
Prosthesis
Prognosis
OTHER TESTICULAR ANOMALIES
Testicular Teratoma
Perinatal Torsion
Acute Scrotum
Polyorchidism
9:
The Evolution of Surgery for Inguinal Hernia
INTRODUCTION
The Preperitoneal Approach
Laparoscopic Hernia Repair
CLASSIFICATION OF GROIN HERNIAS
SALIENT FEATURES OF HERNIA SURGERY
Anterior Repairs
Bassini's Original Operation1
Modified Bassini
Shouldice Operation4
Lichtenstein Hernioplasty
Posterior Repairs
Stoppa's Preperitoneal Repair
Nyhus' Posterior Iliopubic Tract Repair
Anterior cum Posterior Repair
PROSTHETIC MATERIAL USED IN HERNIA SURGERY
WHICH OPEN REPAIR AND WHEN?
LAPAROSCOPIC HERNIA REPAIR
Intraperitoneal Onlay Mesh Repair
Transabdominal Preperitoneal (TAPP) Repair
Total Extraperitoneal (TEP) Repair
COMPARISON OF TAPP AND TEP REPAIR
LAPAROSCOPIC VERSUS OPEN REPAIR
INDICATIONS FOR LAPAROSCOPIC REPAIR AND WHO SHOULD BE DOING IT?
10:
Benign Breast Disease—A Neglected Entity
INTRODUCTION
THE ANDI CLASSIFICATION
Disorders of Development
Disorders of Cyclical Changes
Disorders of Involution
Premalignant Potential of Benign Breast Disorders
BREAST LUMPS
BREAST CYSTS
GALACTOCELE
MASTALGIA
Etiology of Mastalgias
Management of Mastalgia
Non-medical Measures
Medical Methods
Planning of Treatment14
NIPPLE DISCHARGE
Classification
Physiological Galactorrhea
Secondary Galactorrhea
Colored Opalescent Discharge
Watery Discharge
Assessment of Nipple Discharge
Mammography
Galactography
Cytological Examination
MRI
Management of Pathologic Nipple Discharge
Milk or Colored Opalescent Discharge
Blood-related Discharges
Mammary Duct Fistula
Subareolar Abscess
Various Surgical Procedures for BBD61
Excision of Fibroadenoma
Microdochectomy
Mammary Duct Fistula Excision (Fistulectomy)
Radical Duct Excision (Modified Hadfield's Operation)
MAMMOGRAPHICALLY-INDETERMINATE LESIONS
IMAGE-GUIDED BIOPSY IN INDETERMINATE LESIONS
Ultrasound-guided Biopsy
Wire Localization
Stereotactic Biopsy
Mammotome
Stereotactic Vacuum-assisted Core Biopsy
Radio-guided
11:
Postmastectomy Breast Reconstruction
INTRODUCTION
AIM OF BREAST RECONSTRUCTION
TIMING OF RECONSTRUCTION
Immediate Breast Reconstruction
Delayed Reconstruction
BREAST RECONSTRUCTION USING AN IMPLANT
Safety of Implants
BREAST RECONSTRUCTION WITH AUTOLOGOUS TISSUE (FLAP RECONSTRUCTION)
Transverse Rectus Abdominis Myocutaneous (TRAM) Flap
Technique of Raising TRAM Flap
Latissimus Dorsii (LD) Flap
NIPPLE-AREOLA RECONSTRUCTION
12:
Laparoscopic Surgery during Pregnancy
INTRODUCTION
PHYSIOLOGICAL CHANGES IN PREGNANCY
Gastrointestinal System
Cardiovascular and Hematological Changes
Respiratory Changes
Other Organ Systems
Fetal Considerations
Effects of Pneumoperitoneum in the Pregnant Patient
TIMING OF SURGERY
CERTAIN LAPAROSCOPIC PROCEDURES PERFORMED DURING PREGNANCY
Acute Appendicitis
Biliary Tract Disease
Laparoscopy Versus Conventional Surgery in Pregnancy
TECHNICAL RECOMMENDATIONS
13:
Laparoscopic Surgery for Colorectal Cancer
INTRODUCTION
GENERAL ISSUES IN LAPAROSCOPIC SURGERY
Technical Feasibility
Benefits of Laparoscopic Surgery
Quality of Life
Cost-Effectiveness
The Learning Curve
Case Selection
Conversion to Open Surgery
RETRIEVAL OF SPECIMEN
Port-Site Recurrence
Lymph Node Yield and Nature of Margins
Oncologic Outcome
LAPAROSCOPIC RESECTION FOR RECTAL CANCERS SPECIAL POINTS
Tata Memorial Hospital (TMH) Experience
CONCLUSION
14:
Non-ulcer Dyspepsia: Current Concepts in Diagnosis and Management
INTRODUCTION
ETIOLOGY AND PATHOPHYSIOLOGY OF NON-ULCER DYSPEPSIA
Gastric Acid Secretion
Gastric Mucosal Sensitivity
Abnormal Gastric Emptying
Psychological Factor
Helicobacter Pylori
Dietary Factors
APPROACH TO DIAGNOSIS
MANAGEMENT OF NON-ULCER DYSPEPSIA
Antisecretory Agents
Prokinetic Agents
Anti-Helicobacter Pylori Therapy
Antidepressants
Alternate Therapies
15:
Cholangiocarcinoma: A Review of Current Practice
INTRODUCTION
EPIDEMIOLOGY
RISK FACTORS
Primary Sclerosing Cholangitis (PSC)
Hepatolithiasis
Choledochal Cyst
Toxins
Viral Hepatitis
MOLECULAR PATHOGENESIS
PATHOPHYSIOLOGY AND CLASSIFICATION
PRESENTATION
SERUM AND BILE MARKERS
INVESTIGATIONS
TISSUE DIAGNOSIS
STAGING
Ductal Extension
Local Infiltration
Metastatic Disease
TNM Staging
MSKC Modified Staging System
TREATMENT
Preoperative Patient Assessment
Preoperative Biliary Decompression
Surgery
Extent of Surgical Resection for Hilar Cholangiocarcinoma
Portal Vein Embolization
Intrahepatic Cholangiocarcinoma
Distal Bile Duct Carcinoma
Adjuvant Therapy
Radiotherapy
Chemotherapy
Palliation
Surgical Bypass
Stenting
Photodynamic Therapy (PDT)
Palliative Radiotherapy
Liver Transplantation for Cholangiocarcinoma
RESULTS
16:
Approach to Obstructive Jaundice
INTRODUCTION
DEFINITION
INVESTIGATIONS
Liver Function Tests
Alkaline Phosphatase
Gamma-Glutamyl Transpeptidase (GGT)
Coagulation Profile
Tumor Markers
Alpha Feto-Protein (AFP)
Carcinoembryonic Antigen (CEA)
Carbohydrate Antigen (CA 19-9)
RECENT ADVANCES IN MANAGEMENT, RADIOLOGICAL INVESTIGATIONS AND TREATMENT
Ultrasonography (USG)
CT-SCAN, MRCP, EUS, ERCP, PTC
17:
Recent Advances in Gastric Cancer
INTRODUCTION
ETIOLOGY
PATHOLOGY
Chronic Gastritis
Autoimmune Gastritis
Intestinal Metaplasia
Dysplasia
Early Gastric Cancer
Advanced Gastric Cancer
World Health Organization Classification
Spread of Gastric Cancer
SIGNS AND SYMPTOMS OF GASTRIC CANCER
INVESTIGATIONS AND EVALUATION
Upper Gastrointestinal Endoscopy
Computed Tomography (CT Scan)
Laparoscopy
Endoscopic Ultrasonography (EUS)
TREATMENT
Surgical Management
Extent of Gastric Resection
Extent of Lymphadenectomy
D1 versus Extended Lymphadenectomy
Dutch Gastric Cancer Trial
British Medical Research Council Gastric Cancer Surgical Trial
D3 Lymphadenectomy
The Role of Palliative Surgery
Adjuvant Treatment
Chemotherapy
Radiotherapy
SUMMARY
ACKNOWLEDGMENT
18:
Enterocutaneous Fistula
INTRODUCTION
ETIOLOGY
CLASSIFICATION
Anatomical Classification
CLASSIFICATION OF FISTULA ACCORDING TO OUTPUT
PHYSIOPATHOLOGICAL PROBLEMS PRODUCED BY FISTULA
NONSURGICAL MANAGEMENT
Correction of Fluid and Electrolyte Imbalance and Resuscitation
Skin Protection
Nutritional Support
Pharmacological Treatment
Somatostatin
Antibiotics
Detection of Collection(s): Abscess Cavities
Radiological Contrast Studies
SURGERY
Group A
Group B
Group C and D
POSTOPERATIVE COMPLICATIONS
PROGNOSIS
19:
Management of Primary Hyperparathyroidism
ETIOPATHOLOGY
CLINICAL MANIFESTATION
Group A: Asymptomatic Group
Group B: Symptomatic PHPT
Group C: Hypercalcemic Parathyroid Crisis
TREATMENT
Asymptomatic PHPT
Preoperative Medical Treatment to Reduce Hypercalcemia
Preoperative Localization (Preinterventional Localization)
Surgical Anatomy
Treatment Aims
Current Approaches in Different Clinical and Intraoperative Settings
Two Localization Studies Positive and Congruent
If Only One Investigation is Positive for Localization
If Localization Study is Negative or If No Studies are Done
If the Localization is Negative or If No Imaging Studies have been done and Only Three Glands are Found at Exploration
If Frozen Section/Paraffin Section Shows Carcinoma
Failed Exploration
Postoperative Treatment
CAUSES OF RECURRENT HYPERPARATHYROIDISM
FUTURE DIRECTIONS
20:
Venous Ulcer: Current Perspectives
INTRODUCTION
CHRONIC VENOUS INSUFFICIENCY (CVI) – PATHOPHYSIOLOGY
Major Veins
Microcirculation
Hematological Changes in CVI
INVESTIGATIONS
Phlebography
Ascending Phlebography
Descending Phlebography
Duplex Scanning
Other Investigations
Liquid Crystal Thermography
Varicography
Ambulatory Venous Pressure (AVP)
Photoplethysmography, Light Reflection Rheography and Quantitative Digital Photoplethysmography
Ambulatory Strain Gauge Plethysmography
Air Plethysmography
Foot Volumetry
Measurement of Venous Tone using Presure-Volume Loops
Capillaroscopy
Skin Biopsy
Transcutaneous Oxygen Tension (TcPO2)
Laser Doppler Fluxmetry
Fluorescence Microlymphography
Lymphoscintigraphy
EVALUATION OF CLINICAL PARAMETERS
TREATMENT OPTIONS
Compression Therapy
Topical Therapy
SURGICAL OPTIONS
CONCLUSION
21:
Surgical Education and Training – New Trends*
INTRODUCTION
PROBLEMS OF OLD STYLE TRAINING
THE CURRENT SURGICAL TRAINING: ITS EVOLUTION
Preregistration House Officer
Senior House Officer
Specialist Registrar
REASONS FOR CHANGES: STREAMLINING THE SYSTEM
Shortening of Surgical Training Time
Limitation of Junior Doctors' Hours: The European Working Time Directive (EWTD)
The National Confidential Enquiry into Patient Outcome and Death (NCEPOD)
Public Expectations
Newer Surgical Procedures
Training via Courses Mandatory
CHANGES IN THE CURRENT SYSTEM
Stop Unsupervised Training
Teach the Teachers
Continued Appraisal
Mandatory Foundation Courses
Small Group Courses
Specialist Courses
Increased Collaboration Between Distant Units
STRUCTURED TRAINING: MODERNIZING MEDICAL CAREERS (MMC)
STRUCTURED EDUCATION
Basic Surgical Training Courses
Higher Surgical Training Courses
Speciality Courses
Training Courses
CONFLICTS
Fitting with the Governments Agenda
Junior Doctor's Hours
The New Consultant Contract
Revalidation/Approval
THE FUTURE
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