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Partha’s Fundamentals of Pediatrics
Swati Y Bhave, A Parthasarathy, MKC Nair, PSN Menon
CHAPTER 1:
Pediatric Care
INTRODUCTION
MATERNAL AND CHILDCARE
Factors Influencing Infant Mortality
INFANT AND UNDER 5 MORTALITY
INFANT AND CHILD MORTALITY
LOW BIRTH WEIGHT FACTOR
MALNUTRITION
DIARRHEA AND ORT
MONITORING OF GROWTH
FAMILY WELFARE
IMMUNIZATION
INFECTIOUS DISEASES
Acute Respiratory Infection
Asthma
Tuberculosis
Malaria
INFANT FEEDING PRACTICES
INTRODUCTION
ESSENTIAL COMPONENTS OF PRIMARY HEALTH CARE POLICY
SUMMARY
INTRODUCTION
Management of Pregnancy
Confinement (Delivery)
Postnatal Visit
Monitoring the Infant
Health Promotion
Health, Hygiene and Nutrition Education at the Community Level
Organization
CHAPTER 2:
History Elicitation and Physical Examination
DEMOGRAPHY
PRESENTING COMPLAINTS
HISTORY OF PRESENT ILLNESS
PAST HISTORY
CONTACT HISTORY
ANTENATAL HISTORY
BIRTH HISTORY
POSTNATAL HISTORY
DEVELOPMENTAL HISTORY
DIETETIC HISTORY
FAMILY HISTORY
SOCIO-CULTURAL AND ECONOMIC HISTORY
IMMUNIZATION HISTORY
HISTORY OF ALLERGIES
PHYSICAL EXAMINATION
General Examination
Vital Signs
Temperature
Respiratory Rate
Pulse Rate
Capillary Filling Time
Blood Pressure
Anthropometry
Weight
Height
Head Circumference
Chest Circumference
Mid-arm Circumference
Arm Span
Weight for Height
Body Mass Index (Rao Index)
Kanawati Index
Developmental Examination
Systemic Examination
Respiratory System
Cardiovascular System
Abdomen
Nervous System
BIBLIOGRAPHY
History Elicitation and Physical Examination
CHAPTER 3:
Newborn Care
INTRODUCTION
CONVULSIVE DISORDERS
Causes
Evaluation
Management
BLEEDING IN NEONATE
Causes
Deficient Clotting Factors
Platelet Disorders
Vascular Factors
Evaluation
Laboratory Tests
Other Tests
Hemorrhagic Disease of the Newborn (HDN)
Thrombocytopenia
Disseminated Intravascular Coagulation (DIC)
NEONATAL INFECTIONS
Superficial Infections
Neonatal Sepsis
Risk Factors
Causes
Symptoms and Signs
Evaluation
Management
Prevention of Infection
Meningitis
Pneumonia in Newborn
Intrauterine Infections
RESPIRATORY DISTRESS IN NEWBORN
Causes
Transient Tachypnea of Newborn
Hyaline Membrane Disease (Type I Respiratory Distress Syndrome)
Predicting the Risk for HMD
Clinical Features
Diagnosis
Treatment
Apnea of Prematurity
Treatment
MECONIUM ASPIRATION SYNDROME (MAS)
CHAPTER 4:
Growth and Development
INTRODUCTION
FACTORS INFLUENCING GROWTH
ENDOCRINOLOGY OF GROWTH
Growth Hormone
IGF Hypothesis of Growth Hormone Action
Thyroid Hormones
Insulin
Glucocorticoids
Androgens
Estrogens
Peptide Growth Factors other than Somatomedins
STUDY OF GROWTH
Growth Spurts
PATTERN OF GROWTH OF VARIOUS ORGANS OF THE BODY
TYPE OF GROWTH STUDY
Cross-sectional Study
Longitudinal Study
Semilongitudinal Study (Mixed longitudinal study)
‘Linked’ Longitudinal Study
STATISTICAL METHODS IN GROWTH
Mean and Standard Deviation
Percentile
Estimation of Percentile from Mean and SD
Acceleration
Testing for Statistical Significance
METHOD OF ASSESSMENT OF GROWTH
HOW TO STUDY GROWTH
Physical Growth
Weight
Length (Crown-heel length)
Stem Length (Crown-rump Length)
Sitting Height
Chest Circumference
Cranial Circumference or Head Circumference
Midarm Circumference
DEVELOPMENTAL ASSESSMENT
Test for Developmental Assessment
Gesell's Method
DDST
Bayley's Scale of Infant Development
The Brazelton Neonatal Behavioral Assessment Scale (NBAS)
Assessment of Intelligence
Stanford-Binet Intelligence Test
Wechsler Intelligence Scale for Children-revised
Goodenough-Draw-A-Man-test
Milestones of Developments
Neonatal Period (1st 4 weeks)
At 4 Weeks
At 8 Weeks
At 12 Weeks
At 16 Weeks
At 28 Weeks
At 40 Weeks Sitting
At 52 Weeks (1 year)
15 Months
18 Months
24 Months
30 Months Motor
36 Months
48 Months
60 Months
DENTAL DEVELOPMENT
Dental Maturity
SKELETAL GROWTH
SKELETAL MATURITY
PRENATAL GROWTH
ASSESSMENT OF INTRAUTERINE GROWTH
POST-NATAL GROWTH UPTO 0 TO 5 YEARS
Weight
The Length/Height
Head Circumference
Velocity of Growth
AGE INDEPENDENT ANTHROPOMETRY
MID-GROWTH SPURT
ADOLESCENT GROWTH
Endocrinology of Puberty
The Adolescent Growth Spurt
Changes in Body Composition
Changes in the Reproductive System
Boys
Girls
Cognitive and Psychosocial Development
Comparisons in Adolescence—Early, Middle, Late
Reference Standard
Growth Monitoring
Influence of Nutrition, Illness and Environment on Growth
Catch-up Growth
INTRODUCTION
PATTERN AND FACTS OF DEVELOPMENT
Early Foundations
Maturation and Learning
Development Follows a Predictable Pattern
Individual Differences Exist in Development
Each Phase of Development has Typical Behavior
Development is Augmented by Stimulation
DEVELOPMENTAL DELAY
Etiology
DEVELOPMENTAL EVALUATION
TRIVANDRUM DEVELOPMENTAL SCREENING CHART (TDSC)
SCREENING FOR HEARING AND VISION ABNORMALITIES
Simple Clues for Assessing Hearing
Simple Clues for Assessing Vision
Neurodevelopmental Evaluation
BIBLIOGRAPHY
Growth and Development
Development of Infants and Young Children
CHAPTER 5:
Infant and Young Child Nutrition
NUTRITIONAL REQUIREMENT
PHYSIOLOGY OF LACTATION
Concepts of Infant Feeding
Benefits of Exclusive Breastfeeding
Contraindications for Breastfeeding
Disadvantages of Artificial Feeding
Baby Friendly Hospital Initiative
DEFINITION
CLASSIFICATION
SPECTRUM OF PEM
Kwashiorkor
Clinical Features
Other Usual Features Observed
Marasmus (Inanition, Athrepsia, Cachexia, Decomposition, Severe Under Nutrition)
MANAGEMENT OF PEM
Resuscitation
Restoration
Rehabilitation
INTRODUCTION
Anthropometry
Jeliffe's Classification
McLaren's Classification (height for age)
Waterlow's Classification (height for age)
Vishweswara Rao's Classification
Waterlow's Classification (weight for height)
McLaren's Classification (weight for height)
BMI (Weight in kg/height in meter2)
MAC to Head Circumference Ratio (Kanawati and McLaren)
Rao and Singh
Ratio of Dugdale
Quac Stick (Quacker arm Circumference Stick)
The Bangle Test
The Shakir's Tape
INTRODUCTION
VITAMIN A (RETINOL)
Vitamin A Prophylaxis Program
VITAMIN D
Rickets
Treatment
Prophylaxis
VITAMIN E (TOCOPHEROLS)
VITAMIN K
VITAMIN B COMPLEX
Vitamin B1 (Thiamine)
Vitamin B2 (Riboflavin)
Vitamin B3 (Niacin, Nicotinic acid)
Vitamin B6 (Pyridoxine)
Vitamin B11 (Folic acid)
Vitamin B12 (Cyanocobalamin)
Pantothenic Acid
Vitamin H (Biotin)
VITAMIN C (ASCORBIC ACID)
CHAPTER 6:
Immunization and Infectious Diseases
INTRODUCTION
Vaccines
Active Immunization
Passive Immunization
Immunoglobulin
Immune System
Sequences following Vaccination
Primary Response
Secondary Response
Cell-mediated immunity (CMI)
Humoral Immunity
Memory
Mucosal Immunization
Factors Influencing Immune Response
ABBREVIATIONS
VACCINES
MEASLES
Etiology
Pathogenesis
Clinical Features
Black Measles
Modifies Measles
Atypical Measles
Diagnosis
Differential Diagnosis
Complications
Treatment
Post-exposure Prophylaxis
Prevention
BIBLIOGRAPHY
The Principles and Practice of Immunization
Childhood Tuberculosis
Poliomyelitis
Diphtheria
Pertussis
Tetanus
Haemophilus Influenzae b Infection
Measles
Mumps
Rubella
Varicella
Enteric Fever
Malaria
Dengue
HIV
Rabies
CHAPTER 7:
Community Pediatrics
INTRODUCTION
DEFINITION
Why Study of Community Pediatrics is Needed?
DEMOGRAPHIC AND VITAL STATISTICS OF INDIA
Common Indicators
Vital Statistics
Selected Indicators of Human Development in India
National Family Health Survey (NFHS) Data (1998–1999)
NATIONAL CHILD HEALTH PROGRAMS IN INDIA
Maternal and Child Health Program
Objectives of MCH Care
Policy Guidelines for Implementation of MCH Programs
Basic Infrastructure and Implementation of MCH Services
Integrated Child Development Service Scheme (ICDS)
Children from 0–6 Years Age Group Sub-divided
Objectives
Services Offered
Infrastructure
Child Survival and Safe Motherhood (CSSM) Program
Essential Newborn Care
Components of Essential Obstetric Care
Reproductive and Child Health Program
Contraception
Antenatal Care
Safe Delivery Services
Postpartum Services
Child Survival Services
Nutrition Supplements for Pregnant and Lactating Women
Integrated Management of Newborn and Childhood Illness (IMNCI)—A Strategy
Background
What is IMCI?
What does IMCI Strive to do?
How IMCI Goals are Achieved?
What are the Main Components of the Strategy?
Integrated Management of Newborn and Childhood Illness (IMNCI)
Goals of IMNCI
National Programs on Immunization
Historical Perspectives
Universal Immunization Program (UIP)
Aims
Objectives
National Immunization Schedule
Cold Chain System
Surveillance of Vaccine Preventive Disease (VPD)
Pulse Polio Immunization (PPI)
Definition
Objective
Operational Strategy
Acute Flaccid Paralysis Surveillance
Impact
Diarrheal Diseases Control Program
Strategies Adopted
“Improved” ORS or a New Reduced Osmolarity Formulation
Acute Respiratory Infections Control Program (ARICP)
Prevalence
Revised National Tuberculosis Control Program (RNTCP) Including Directly Observed Treatment (DOT)
Goals of RNTCP
Directly Observed Treatment
Tuberculosis in Children: Global and Indian Scenario
NTP and Children
RNTCP and Children
Diagnosis and Treatment
National Leprosy Eradication Program
Specific Goal
Salient Features
National AIDS and STD Control Program
Prevention of Parent to Child Transmission (PPTCT) of HIV
Strategies for PMTCT
Benefits
Adverse Reactions of NVP in Children
Nutrition Programs
Special Nutrition Program (SNP)
Mid-day Meal Program
Anemia Control Program
Control of Vitamin A Deficiency
Strategy
National Iodine Deficiency Disorders Control Program
National School Health Program
Under Five Clinics
What are Under Five Clinics?
Skills Required for a Doctor for Effective Participation in National Child Health Programs
Related to Nutrition
Related to Diarrhea/Dehydration
Related to ARI Control
Related to Maternal Care
Related to Vaccination Program
Some Important Occasions for Spreading the Child Health Themes in Community
SPECTRUM OF COMMUNITY PEDIATRIC ACTIVITIES
CHAPTER 8:
Diseases of Central Nervous System
INTRODUCTION
Examination of the Skull
Examination of the Spine
General Physical Examination
Examination of the Cranial Nerves
Optic Nerve
III, IV, VI (Oculomotor) Nerves
Trigeminal Nerve
Facial Nerve
Acoustic Nerve
Glossopharyngeal Nerve
Vagus Nerve
Spinal Accessory Nerve
Hypoglossal Nerve
Motor System
GAIT
ATAXIA
TEST METHODS
SENSORY SYSTEM
HIGHER CORTICAL SENSORY FUNCTION
INTRODUCTION
Incidence
Definition
Degree of Fever
Classification and its Significance
Genetics
Diagnosis
Lumbar Puncture
EEG
Investigations
Recurrences
Long-term
Cognitive
Mesial Temporal Sclerosis
Behavior and Social Aspects
Treatment
Antipyretics
Anticonvulsants
Intermittent prophylaxis
Long-term
Conclusions
INTRODUCTION
Newer Concepts
Newer Anticonvulsants
Non-pharmacological Method
Surgery for Epilepsy
BACTERIAL MENINGITIS
INTRODUCTION
CLINICAL FEATURES IN CHILDHOOD
DIFFERENTIAL DIAGNOSIS
INVESTIGATIONS
CLINICAL NEUROPHYSIOLOGY
PATHOGENESIS
PROGNOSIS
TREATMENT
INTRODUCTION
MAGNITUDE
ETIOLOGY
Prenatal Causes
Malformations
Environmental Factors
APPROACH TO A CHILD WITH MENTAL RETARDATION
Associated Comorbidities
MANAGEMENT
CEREBRAL PALSY
Introduction
Definition
Etiology:
Prenatal
Perinatal
Postnatal
Classifications (Table 8.11)
Clinical Features
Spastic Hemiplegia (Figure 8.7)
Spastic Diplegia
Spastic Quadriplegia
Athetoid CP (extrapyramidal CP)
Atonic CP
Ataxic CP
Diagnosis
Management
HYDROCEPHALUS
CHOREA
MICROCEPHALY
Definition
Classification
Primary (Genetic)
Secondary (Non-Genetic)
Causes
Clinical Features
Associated Anomalies
Differential Diagnosis
Treatment
Prognosis
BIBLIOGRAPHY
Introduction to Seizure Disorders
Febrile Seizures
Epilepsy
Eplieptic Seizure
Bacterial Meningitis
Tuberculous Meningitis
Encephalitis in Children
Other CNS Disorders
CHAPTER 9:
Diseases of Cardiovascular System
INTRODUCTION
FIVE FINGER APPROACH TO CARDIOVASCULAR DIAGNOSIS
ALRI
Wheeze
Perspiration
Cough
Hemoptysis
Other Symptoms
HISTORY
GENERAL EXAMINATION
General examination
Cyanosis
CVS EXAMINATION
Pulse
Pulse
Jugular Venous Pulse (JVP)
BLOOD PRESSURE
PRECORDIAL EXAMINATION
Heart Sounds
Murmurs
Systolic
Diastolic
Continuous Murmur
Innocent Murmurs in a Child
CLINICAL PRESENTATION OF CHD IN INFANTS AND CHILDREN
LEFT TO RIGHT SHUNTS
STENOTIC LESIONS
REGURGITANT LESIONS
VENTRICULAR SEPTAL DEFECT (VSD)
Investigations
Natural History and Complications
VSD—Natural History
Management
Surgical Therapy
Indications for Surgery
ATRIAL SEPTAL DEFECT (ASD)
Secundum ASD
Clinical Differential Diagnosis
Investigations
Management
Primum ASD
Sinus Venosus ASD
PATENT DUCTUS ARTERIOSUS (PDA)
Types
Small
Moderate
MURMUR OF PDA
Investigations
MANAGEMENT
AORTIC STENOSIS (AS)
Investigations
Treatment
PULMONARY STENOSIS (PS)
Investigations
Treatment
COARCTATION OF AORTA (CoA) (Figures 9.20 to 9.22)
Management
TETRALOGY OF FALLOT (TOF)
Components
Associated Lesions
Clinical Features
Complications
Treatment of Hypoxic Spell
Newer Modalities
Investigations
TREATMENT
Medical
Surgical
TRANSPOSITION OF GREAT ARTERIES (TGA) (Figures 9.27 to 9.29)
TRICUSPID ATRESIA (TA) (Figures 9.30 to 9.33)
Acyanotic
Aortopulmonary Window
Anomalous Origin of Left Coronary Artery from Pulmonary Artery (ALCAPA)
Cyanotic
TAPVC
Complete AV Canal Defect (AVCD) or AVSD
Ebstein Anomaly
Truncus Arteriosus
Single Ventricle
L-TGA
RHEUMATIC FEVER (RF)
Epidemiology
Epidemiology of RF
Environment
Prevalence
Prevalence Studies
Rheumatic Fever: Decreasing Incidence
Etiopathogenesis
Clinical Features
Rheumatic Recurrence
Polyarthritis
Carditis
Poststreptococcal Reactive Arthritis (PSRA)
Diagnostic Investigations
Antistreptococcal Antibodies
Identification of Organism
ECG in ARF
Echocardiography in Acute Rheumatic Carditis
Treatment
Principles
Treatment of GAS Infection - Choices
Carditis—Steroids or Aspirin?
Treatment of Complications
Recurrence of RF
RHEUMATIC HEART DISEASE (RHD) FOLLOWING RHEUMATIC FEVER
Rheumatic Prophylaxis
Anaphylaxis
MITRAL STENOSIS (MS)
Clinical Features
Clinical
CXR
ECG
Management
Medical
Definitive Treatment
MITRAL REGURGITATION (MR)
Murmurs
Diagnosis
Treatment
Acute MR
AORTIC REGURGITATION (AR)
Clinical Features
Diagnosis
Management
Medical
CHEST X-RAY IN PEDIATRIC CARDIOVASCULAR DISEASES
DEMYSTIFYING PEDIATRIC ECG
Introduction
Calculating Heart Rate
P Wave
PR Interval
QRS Complex
Amplitude
Q Wave
Transition
QRS Axis
ST Segment
T Wave
QTC (Corrected QTinterval)
U Wave
Abnormal ECG
Left Atrial Enlargement
Right Atrial Enlargement
Left Ventricular Hypertrophy
Right Ventricular Hypertrophy
Biventricular Hypertrophy
Heart Blocks
Arrhythmias
Atrial Ectopics
Ventricular Ectopics
ECG in Individual Lesions
PEDIATRIC CARDIAC CARE—DRUGS AND DRUG DOSAGES
LIST OF ABBREVIATIONS
CHAPTER 10:
Diseases of Respiratory System
INTRODUCTION
ANATOMY OF LUNGS
DIFFERENCE BETWEEN PEDIATRIC AND ADULT AIRWAY
PULMONARY DEFENSE MECHANISMS
DEFENSE SYSTEM OF THE RESPIRATORY TRACT
Anatomic Design of Respiratory Tract
Mucociliary Escalator
Immune Defence
MECHANISMS OF INFECTION IN THE LUNG
INTRODUCTION
RESPIRATORY TRACT INFECTIONS
MAGNITUDE OF THE PROBLEM
DEFINITIONS
COMMON COLDS
Prevention and Cause
Treatment
INTRODUCTION
Diagnosis
Microbiology and Treatment of Acute Sinusitis
GROUP A BETA-HEMOLYTIC STREPTOCOCCI
DIFFERENTIAL DIAGNOSIS OF PHARYNGITIS
DEFINITION
AGE GROUP
OCCURRENCE
ETIOLOGY
RISK FACTORS
IMMUNE MECHANISMS
CLINICAL FEATURES
INVESTIGATIONS
PREVENTION
TREATMENT
Supportive Treatment (Main stay)
Bronchodilators
Racemic Epinephrine and Salbutamol
L-Epinephrine and Salbutamol
Glucocorticoids
BRONCHIOLITIS OBLITERANS
INVESTIGATIONS
INTRODUCTION
ETIOLOGY
EPIDEMIOLOGY
CLINICAL FEATURES
Laryngotracheobronchitis
Acute Epiglottitis
Acute Infectious Laryngitis
Acute Spasmodic Laryngitis (Spasmodic Croup)
Acute Bacterial Tracheitis
DIFFERENTIAL DIAGNOSIS
COMPLICATIONS
TREATMENT
Home Treatment
Indications for Hospitalization
General Principles
Role of Epinephrine
Role of Steroids
To summarize
Endotracheal Intubation and Tracheostomy
Role of Antibiotics
PNEUMONIA
Step I
Step II
Community Acquired Pneumonia
Therapy
High Risk Group
Step III
Criteria for Severe Cases
Hospital Acquired Pneumonia (HAP)
Opportunistic Pneumonia
Tuberculous Lung Infection
Suppurative Lung Disease
CONCLUSION
INTRODUCTION
DEFINITIONS
ORGANISMS CAUSING PARAPNEUMONIC EFFUSION AND EMPYEMA THORACIS
SPREAD OF INFECTION
STAGES OF EMPYEMA THORACIS
PATHOPHYSIOLOGY OF EMPYEMA THORACIS
DIAGNOSIS
GUIDELINES FOR MANAGEMENT
Principles of Management
Antimicrobial Therapy
Closed Tube Thoracostomy
Physiotherapy
Nutritional Support
Supportive Care
Empyema Thoracis: Newer Interventions
BIBLIOGRAPHY
Rhinitis
Sinusitis
Pharyngitis
Croup Syndrome
CHAPTER 11:
Diseases of Gastrointestinal System and Liver
DEFINITIONS
CONSEQUENCES OF DIARRHEA
ETIOLOGY
MECHANISMS
INVESTIGATIONS IN ACUTE WATERY DIARRHEA
APPROACH TO A CHILD WITH DIARRHEA
Step 1: Confirm—is it Diarrhea?
Step 2: Is it Small Bowel Diarrhea or Large Bowel Diarrhea?
Step 3: Assess the Hydration Status and Institute the Necessary Treatment Plan
PITFALLS WHILE ASSESSING DEHYDRATION
Plan‘A’
Plan ‘B’
Physiological Basis of ORS
Rice-based ORS and Maltodextrin-based ORS
Amino Acid-based ORS
WHO Low Osmolar ORS
How much to give and how often?
Causes of Failure of Plan ‘B’
Treatment Plan ‘C’
COMPLICATIONS
ROLE OF ZINC
ROLE OF RACECADOTRIL
ROLE OF PROBIOTICS
ROLE OF ANTIMICROBIALS
SPECIAL PROBLEMS IN THE MALNOURISHED AND INFANTS LESS THAN TWO MONTHS OF AGE
DRUGS TO BE AVOIDED
LACTOSE MALABSORPTION
PREVENTION OF DIARRHEA
INTRODUCTION
DEFINITION
CLASSIFICATION
EPIDEMIOLOGY
PATHOPHYSIOLOGY OF CHRONIC DIARRHEA
Watery Diarrhea
Secretory Diarrhea
Defects in Ion Transport Proteins
Osmotic Diarrhea
Chronic Diarrhea a Complex Disorder
Clinical Picture
Etiology of Chronic Diarrhea
APPROACH TO CHRONIC OIARRHEA
Approach to Chronic Secretory Diarrhea
Approach to Chronic Osmotic Diarrhea
Approach to Chronic Inflammatory Diarrhea
Approach to Fatty Diarrhea
Functional Diarrhea
Toddler's Diarrhea
Factitious Diarrhea
TREATMENT
CERTAIN SPECIFIC CONDITIONS
Tuberculosis
Cow Milk Protein Allergy
Acrodermatitis Enteropathica
Intestinal Lymphangiectasia
Pancreatic Disorders
Celiac Disease
Inflammatory Bowel Diseases
Dysentery
PROGNOSIS AND OUTCOME
PREVENTION
INTRODUCTION
Modified Apley and Naish Criteria
CLASSIFICATION OF RAP
RAP seen in Psychiatric Illnesses
Dysfunctional Abdominal Pain
Temperament and Learned Response
Lifestyle and Habits
Milieux and Critical Events
Somatic Predisposition
Typical Dysfunctional Pain is Characterized by
Organic Pain
Diseases that Cause Recurrent Abdominal Pain
Do Not Miss
INVESTIGATIONS OF RAP
MANAGEMENT OF RAP
Management of Dysfunctional RAP
Drug Therapy
Dietary Management
PROGNOSIS
INTRODUCTION
Predisposing Factors
CLINICAL FEATURES
INVESTIGATIONS
Naked Eye Examination
Direct Stool Microscopy
Characteristics of the Parasites in Stool Microscopy
Proctosigmoidoscopy
Eosinophilic Count
Serological Tests
TREATMENT
INTRODUCTION
UPPER GASTROINTESTINAL (UGI) BLEEDING
Epidemiology
Manner of Presentation
Acute Blood Loss
Chronic Blood Loss
Severe/Massive Bleeding Criteria
Etiology of UGI Bleeding
Diagnostic Evaluation of UGI Bleeding
Management of UGI Bleeding
Resuscitation
Portal Hypertension
Acute Variceal Bleeding
Supportive Measures
Pharmacotherapy
Balloon Tamponade
Endoscopic Treatment
Esophageal Variceal Bleeding
Endoscopic Variceal Ligation (EVL) (Figure 11.12)
Beta Adrenergic Antagonist
Nitrovasodilators
Surgery
NONVARICEAL BLEEDING
Esophagitis
Barrett's Esophagitis
Candida Esophagitis
Mallory-Weiss Tear
ACID PEPTIC DISEASES (APD)
Peptic Ulcer
Gastritis and Doudenitis
Hemobilia
Aorto-enteric Fistula
VASCULAR LESIONS
Vascular Anomalies Associated with Skin Lesions
Vascular Anomalies without Associated Skin Lesions
Corrosive Ingestion
PROGNOSIS
PREVENTION
INTRODUCTION
EPIDEMIOLOGY
DEFINITION
PRESENTATION
GRADES
PATHOPHYSIOLOGY
ETIOLOGY
APPROACH TO LGI BLEED
History
Examination
Investigations
Basic Investigations
Proctoscopy and Sigmoidoscopy
Upper GI Endoscopy
Radiology
Colonoscopy
Enteroscopy
Capsule Endoscopy
Angiography
Radionuclide Scanning
Specific Conditions
OUTCOME AND PROGNOSIS
DEFINITION
COMMON CAUSES
PATHOPHYSIOLOGY
CLINICAL FEATURES
Symptoms
Signs
Demonstration
Work up
Basic Investigations
Special Investigations
Ascites Tap
MANAGEMENT
High Albumin Gradient Ascites: Management
Special forms of Ascites
Chylous Ascites
Refractory Ascites
Treatment
DEVELOPMENT
ANATOMY
Blood Supply
Lymphatics
Structure of Liver
Main Functions of Liver
Liver Span
INTRODUCTION
Tests that Reflect Injury to Hepatocytes
Aminotransferases
Tests that Indicate Cholestasis
Alkaline Phosphatase (SAP)
Gamma Glutamyl Transpeptidase (γGTP)
5' Nucleotidase
Tests that Measure Capacity to Transport Organic Anions
Serum Bilirubin
Urine Bilirubin
Urine Urobilinogen
Serum Bile Acids
Serum Ammonia
Tests that Measure the Capacity of the Liver to Metabolize Drugs
Lidocaine Metabolite Formation
Tests that Measure Hepatic Synthetic Function
Serum Albumin
Prothrombin Time (PT)
Activated Partial Thromboplastin Time (APTT)
Lipoprotein
Tests that Detect Chronic Inflammation or Altered Immune Regulation
Markers of Liver Fibrosis and Fibrinolysis
Miscellaneous Tests for Etiology
INTRODUCTION
CONS
Surface
Edge of Liver
Tenderness, Rubs and Bruit
Liver Enlargement
Causes
Splenomegaly
Massive Splenomegaly with Minimal Hepatomegaly
Moderate/Mild Splenomegaly
Causes of Hepatosplenomegaly
INTRODUCTION
Hepatitis A
Pathogenesis
Clinical Manifestations
Diagnosis
Prevention
Hepatitis B
Transmission
Pathogenesis
Clinical Manifestations
Natural History
Serology
Prevention
Hepatitis C
Clinical Manifestations
Diagnosis
Prevention
Hepatitis D
Clinical Manifestations
Diagnosis
Prevention
Hepatitis E
Clinical Manifestations
Diagnosis
Prevention
Hepatitis F
Hepatitis G
Clinical Manifestations
SEN and TT Virus
SPECTRUM AND COMPLICATIONS OF ACUTE VIRAL HEPATITIS
LABORATORY WORK UP
DIFFERENTIAL DIAGNOSIS OF ACUTE VIRAL HEPATITIS
SUPPORTIVE MEASURES
PREVENTION
INTRODUCTION
Common Causes
Pathogenesis of HBV Hepatitis
Chronic Hepatitis C
Autoimmune Hepatitis
Drug-induced Chronic Hepatitis
Wilson's Disease (Hepatolenticular Degeneration)
Clinical Features of Chronic Hepatitis
Diagnostic Work-up
Management of Chronic Hepatitis
INTRODUCTION
PATHOGENESIS
CLINICAL ASPECTS
GENERAL CLINICAL EXAMINATION IN CIRRHOSIS
DIAGNOSIS
Labarotary Investigations
Screening for Metabolic Liver Disease
Wilson's Disease
α1 Antitrypsin Deficiency
Glycogen Storage Disease
Tyrosinemia
Galactosemia
Hemochromatosis
Cystic Fibrosis
Autoimmune Hepatitis
Ultrasonogram
Liver Biopsy
COMPLICATIONS OF CIRRHOSIS
DIFFERENTIAL DIAGNOSIS
TREATMENT
WELL COMPENSATED CIRRHOSIS
NUTRITION
Drugs
Hepatocellular Failure
Encephalopathy
PREDISPOSING CAUSES
MANAGEMENT GUIDELINES
SPECIFIC TREATMENT
Treatment of Ascites
BIBLIOGRAPHY
Acute Watery Diarrhea
Chronic Diarrhea in Children and Infants
Upper GI Bleeding in Children
Lower GI Bleeding in Infants and Children
Ascites
Hepatosplenomegaly
Liver and Biliary System
Liver Function Tests
Acute Viral Hepatitis
Chronic Hepatitis in Children
Cirrhosis of Liver in Children
CHAPTER 12:
Diseases of Kidney and Urinary Tract
DEFINITION
ETIOLOGY
PATHOGENESIS
INCIDENCE
CLINICAL MANIFESTATIONS
LABORATORY FINDINGS
Urine
Blood
Serology
Microbiology
Radiology
Ultrasonogram
Renal Biopsy
DIFFERENTIAL DIAGNOSIS
Urinary Tract Infection
Cystitis
Congestive Cardiac Failure
Seizure Disorders
Nephrotic Syndrome
Progressive Glomerulonephritis, Systemic Vasculitis and Familial Glomerulopathy
CLINICAL COURSE
COMPLICATIONS
Hypertensive Encephalopathy
Circulatory Overload
Acute Renal Failure
MANAGEMENT
General Measures
Hospital Treatment
Bed Rest
Fluid Balance
Dietary Modulation
Drug Treatment
Streptococcal Infection
Edema, Circulatory Congestion and Volume Overload
Hypertension
Convalescence
PROGNOSIS
DEFINITION
EPIDEMIOLOGY
PATHOPHYSIOLOGY
Mechanism of Proteinuria
Mechanism of Hypoproteinemia
Mechanism of Hypercholesterolemia
CLASSIFICATION
HISTOLOGY
CLINICAL FEATURES
History
Presentation
Physical Examination
LABORATORY EVALUATION
Imaging Studies
MANAGEMENT
Decision of Hospitalization
Symptomatic and Supportive Therapy
Diet
Activity
Diuretics
Specific Therapy
Corticosteroids and Alkylating Agents
Definitions of Response
Cyclosporin A
LONG-TERM ISSUES
Parent Education
Immunization
PROGNOSIS
DEFINITION
CLASSIFICATION
Based on Clinical Expression
Anatomical Basis
PRESENTING SYMPTOMS
DIAGNOSTIC FEATURES SUGGESTIVE OF UTI IN A FEBRILE CHILD
DIAGNOSIS OF UTI
HOW TO DIFFERENTIATE BETWEEN UPPER UTI AND LOWER UTI?
INVESTIGATIONS
MANAGEMENT
Initial Therapy
Prophylactic Antibiotics
Dosage of Antibiotics
Indications for Radiological Investigations
Long-term Follow-up
DEFINITION
IMPORTANCE OF BP MEASUREMENT
The Natural History of Blood Pressure in Children
Factors that Determine Blood Pressure
ETIOLOGY
Clues to Primary and Secondary Hypertension in Children
SIGNS AND SYMPTOMS
ESSENTIAL HYPERTENSION IN CHILDREN
INVESTIGATIONS IN HYPERTENSION
Urinalysis
Blood Count
Routine Serum Chemistry
X-ray Chest and Abdomen
Echocardiography
Ultrasonogram of Abdomen
Intravenous Urogram (IVU)
Voiding Cystourethrogram (VCUG)
Radionuclide Imaging
Computerized Tomography of Kidneys
Doppler Flow Ultrasound
Selective Renal Angiography
MRI Arteriogram
CT Angiography
Renal Vein Renin Assay
Peripheral Plasma Renin Activity
Plasma Aldosterone
Serum Cortisol and 24 Hours Urinary 17 Hydroxy Corticosteroid
Urinary and Plasma Catecholamine Levels
Metaiodobenzylguanidine (MIBG) Scan
TREAMENT OF HYPERTENSION
Antihypertensive Medication
DEFINITION
ETIOLOGY
Prerenal Failure
Intrinsic Renal Failure
Postrenal Failure
PATHOPHYSIOLOGY
CLINICAL MANIFESTATIONS
DIAGNOSTIC APPROACH
MANAGEMENT OF ARF
Initial Therapy
COMPLICATIONS OF ARF
Hyperkalemia
Hyponatremia
Metabolic Acidosis
Hypocalcemia Accompanied by Hyperphosphatemia
Hypertension
Infection
Nutrition
RENAL REPLACEMENT THERAPY
RECOVERY FROM ARF
PROGNOSIS
DEFINITION
ETIOLOGY
PATHOLOGIC PHYSIOLOGY
CLINICAL MANIFESTATIONS
HISTOLOGY
RENAL COMPENSATORY FUNCTION IN THE DISEASED KIDNEY
CLINICAL FEATURES
Excretion of Wastes
Metabolic Abnormalities
Sodium and Water
Potassium
Acid-base Balance
Calcium, Phosphate, and Bone Metabolism
Clinical Manifestations
Anemia
Coagulopathy
Neuromuscular System
Nutrition and Growth
Immunologic Defects
Hypertension
Uremic Syndrome
MANAGEMENT OF COMPLICATIONS
Retardation of Progression of CRF
Activity
Protein and Caloric Requirements
Sodium, Potassium, and Minerals
Acidosis
Osteodystrophy
Hematologic Complications
Cardiovascular Complications
Pulmonary Complications
Intercurrent Infection
Convulsions
PROGNOSIS
POSTERIOR URETHRAL VALVES
Incidence
Embryology
Pathogenesis
Antenatal Diagnosis and Therapy
Postnatal Presentation of Valves
Types of Valves
Investigations
Renal Ultrasound
Micturating Cystourethrogram (MCU)
Management
Prognosis
OBSTRUCTIVE MEGAURETER
Incidence
Presenting Symptoms
Investigations
Management
Surgery
URETEROCELES
Definition
Incidence
Presentation
Diagnosis
Management
PELVI-URETERIC JUNCTION (PUJ) OBSTRUCTION
Pathophysiology
Presentation
Investigations
Ultrasound
Intravenous Urogram
DTPA Renal Scan
Micturating Cystourethrogram
Treatment
Surgical
Medical
DEFINITION
PATHOPHYSIOLOGY OF REFLUX
TYPES OF VUR
VUR AND REFLUX NEPHROPATHY
PATHOGENESIS OF SCARRING
PRESENTATION OF VUR
DIAGNOSIS OF REFLUX
GRADES OF REFLUX
TREATMENT GUIDELINES
General Principles
Medical Therapy
Surgical Therapy
Newer Modalities of Treatment
Secondary Reflux
CHAPTER 13:
Hematology and Oncology
INTRODUCTION
CLASSIFICATION
SYMPTOMATOLOGY OF ANEMIA
NUTRITIONAL ANEMIA IN INFANCY AND CHILDHOOD
IRON DEFICIENCY ANEMIA (IDA)
Classification of Iron Deficiency
Stages of Iron Deficiency
First Stage
Second Stage
Third Stage
Clinical Features of IDA
Peak Incidence
Signs and Symptoms
Investigations (Flow chart 13.1)
Management
Difficulties Encountered with Oral Iron
Response to Treatment (Table 13.9)
Transfusion Therapy
Prevention of IDA
MEGALOBLASTIC ANEMIA
Causes of Nutritional Megaloblastic Anemia
Clinical Features
Investigations
Treatment
THALASSEMIA
Epidemiology
Classification
Pathophysiology (Flow chart 13.2)
Molecular Genetics
Clinical Manifestations of β-thalassemia (Figs 13.7 to 13.9)
Investigations
Management of a Thalassemic Child
Transfusion Therapy
Indications for Transfusion Therapy
Type of Transfusions
Amount and Rate of Transfusions
Adequacy of Transfusions
Advances in Transfusion Therapy
Complications of Transfusions
Iron Overload and Chelation Therapy
Newer Chelating Agents
HBED – Hydroxy Benzyl– Ethylenediamine-Diacetic Acid
Pyridoxal Isonicotinoyl Hydrazones (PIH)
Current Status of Iron Chelators
Gene Manipulation
Splenectomy
Bone Marrow Transplantation
Endocrine Evaluation and Growth Monitoring
Cardiac Complications
Bone Disease in Thalassemia Major - Osteopenia and Osteoporosis
WHO Criteria for Osteopenia and Osteoporosis
Treatment of Osteopenia and Osteoporosis Includes the Following
Monitoring for Bone Disease in Thalassemic Children
Prevention of Thalassemia
Population Education
Mass screening
Genetic Counseling
Prenatal/Antenatal Diagnosis
Genetic Engineering
SICKLE CELL DISEASE
Epidemiology
Pathophysiology
Types of Sickle Cell Disease
Clinical Features
Vaso-occlusive Crisis
Sequestration Crisis
Megaloblastic Crisis
Aplastic Crisis
Other Common Manifestations
Diagnosis and Management
Management
IMMUNE HEMOLYTIC ANEMIA
Classification
Clinical Features (Fig. 13.21)
Laboratory Diagnosis
Management
RED CELL MEMBRANE DISORDERS (MEMBRANOPATHIES)
Types of Red Cell Membrane Disorders
Acquired RBC Membrane Defects
Hereditary Spherocytosis (HS)
Clinical Features
Laboratory Features
Other Causes of Spherocytosis
Management
RED CELL ENZYM0PATHY
Clinical Features
Chronic Hemolytic Anemia
Diagnosis and Investigations
Laboratory Investigation Includes
Management
Pyruvate Kinase Deficiency
Management
BONE MARROW FAILURE SYNDROME
Epidemiology
Classification (Table 13.12)
Pathophysiology
Seed and Soil Theory
Clinical Picture
Laboratory Findings
Management of Aplastic Anemia
Bleeding
Infections
Specific Treatment for Aplastic Anemia
Immunotherapy
Inherited Type of A/Hypoplastic Anemia
Pure Red Cell Aplasia
Laboratory Investigations
Transient Erythroblastopenia of Childhood (TEC)
Inherited Types of Aplastic Anemia
Pathophysiology
Epidemiology
Clinical Features
Laboratory Diagnosis
Treatment and Prognosis
Dyskeratosis Congenita (Fig. 13.27)
Thrombocytopenia with Absent Radius
ANEMIA IN THE NEWBORN
NORMAL VALUES OF HEMATOLOGICAL PARAMETERS IN THE NEWBORN
Hematological Parameters
Hemoglobin
Hematocrit
Red Cell Count and Red Cell Indices
Reticulocyte Count and Nucleated Red Blood Cells (NRBC)
Reticulocytosis in the Cord Blood
Factors Affecting Normal Hematological Values in Newborn
Site of Sampling
Time of Sampling
Treatment of Umbilical Vessels
Position of the Neonate after Delivery
Criteria for Anemia
Etiology of Anemia (Flow chart 13.3)
Hemorrhage
Malformation of Placenta/Cord/Obstetric Accidents
Fetomaternal Hemorrhage
Causes of fetomaternal hemorrhage include
Clinical Presentation of Fetomaternal Hemorrhage
Fetofetal Hemorrhage (Twin to Twin Transfusion)
Internal Hemorrhage
Iatrogenic Anemias
ANEMIA DUE TO INCREASED RBC DESTRUCTION (HEMOLYTIC ANEMIAS)
Isoimmunization
Management
Congenital Defects of Red Cells
Defects of red cell metabolism
Pyruvate Kinase Deficiency
Abnormalities of Red Cell Membrane
Hereditary Spherocytosis
Treatment
Hereditary Elliptocytosis
Hereditary Stomatocytosis
Impaired Red Cell Production
Diamond Blackfan Syndrome
Laboratory Findings
Fanconi's Anemia
Treatment
IDIOPATHIC THROMBOCYTOPENIC PURPURA (ITP)
Classification
ACUTE ITP
CHRONIC ITP
IN RECURRENT ITP
Diagnosis of ITP
Platelet Count
Leukocyte Count
Anemia
Bone Marrow Examination
Indication for bone marrow aspiration
Anti-platelet Antibody
Other Investigations
Management of ITP
In chronic ITP
SPECIFIC THERAPY IN ACUTE ITP
Corticosteroid Therapy
Steroids in ICH
Indications for steroids in ITP
Dose of steroids
INTRAVENOUS PULSE METHYLPREDNISOLONE PULSE THERAPY
Intravenous immunoglobulin
Reactions
IVIgG in chronic ITP
Anti-D in ITP
SPLENECTOMY IN ITP
Splenectomy in acute ITP is done: definitely
Splenectomy in chronic ITP
Problems After Splenectomy
Role of Non-steroidal Immunosuppressant Drugs in Chronic ITP
ALPHA INTERFERON
CONCLUSION
DISSEMINATED INTRAVASCULAR COAGULATION
Pathophysiology
ETIOLOGY
Neonatal Causes
Obstetrics Complications
Collagen Vascular Diseases
Miscellaneous
CLINICAL FEATURES (Figs 13.36 to 13.38)
Diagnosis
Recognizing clinical setting that can leads to DIC
Management and Treatment
Main stay of treatment include
Replacement Therapy
HEMOPHILIA SYNDROMES
Types of Hemophilia (Table 13.7)
Classification
Incidence
Severity of Hemophilia
Grade of Hemophilia
Inheritance
Clinical Presentation
Early Manifestation in Newborn Period
Clinical Manifestations may be Delayed till Child Start Walking and Playing
Diagnosis and Laboratory Investigations
Antenatal Diagnosis
Management of Hemophilia
Prevention of Bleeding in Hemophiliacs and Management
Replacement of Deficient Factor to Prevent Hemorrhage
In what form?
Cryoprecipitate
Cryoprecipitate contains
Advantages
Disadvantages
Factor VIII Concentrate (Lyophilized Antihemophilic Factor)
Advantages
Disadvantages
Prothrombin Complex Concentrates (PCC)
Advantages
Disadvantages
Activated Prothrombin Complex Concentrates (APCC)
Porcine Factor VIII Concentrate
How much to give?
How often?
Plasma-borne Infections
What are the Types of Treatment?
Episodic or on Demand Treatment
Supervised Self Treatment
BLEEDING NEONATE
Normal Hemostasis Mechanism
Primary Hemostasis
Secondary Hemostasis
Fibrinolysis
Role of Vitamin ‘K’ in neonatal hemostasis
Qualitative
Coagulation Factor Deficiency
APPROACH TO A BLEEDING NEONATE
History
Maternal History
Birth History
Family History
Physical Examination
Site of Bleeding
Laboratory Approach
Thrombin Clotting Time
Confirmatory Tests
Coagulation Factors Defects
Healthy Child (Tables 13.21 to 13.23)
Sick Child
APPROACH TO A BLEEDING CHILD
Indications for Investigations
Local cause should be suspected when
In a generalized bleeding disorders
Autosomal recessive disorders
Conversely Patients with Acquired Disorders
Syndromes known to be Associated with Bleeding Disorders
Laboratory Evaluation
Screening Tests (Table 13.24)
Platelet Count
Bleeding Time
Clot Retraction
PT and APTT
Special confirmatory tests (Figs 13.50 and 13.51)
INTRODUCTION
Childhood vs Adult Lymphoma
Histologic Classification
Lymphoma or Leukemia
Immunology of Childhood NHL
Cytogenetics of Childhood NHL
CLINICAL FEATURES
Staging
MANAGEMENT
Lymphoblastic Lymphoma
Chemotherapy
Non-lymphoblastic Lymphoma
Chemotherapy
CNS Prophylaxis
Role of Radiotherapy
Other Problems
INCIDENCE
ETIOLOGY
PATHOLOGY (TABLE 13.27)
CLINICAL PRESENTATION
Extranodal Sites
Symptoms
TREATMENT
Principles of Radiotherapy
Staging
Principles of Chemotherapy
Prognostic Factors
INTRODUCTION
EPIDEMIOLOGY
PATHOLOGY
PATTERN OF SPREAD
CLINICAL FEATURES
INVESTIGATIONS
STAGING
TREATMENT
INTRODUCTION
EPIDEMIOLOGY
PATHOLOGY
Genetics and Molecular Biology
CLINICAL FEATURES
DIAGNOSIS
STAGING
RISK CATEGORIES
TREATMENT
INTRODUCTION
Rhabdomyosarcoma
Ewing's Sarcoma
INTRODUCTION
HEMATOPOIETIC FACTOR STIMULATING RBC PRODUCTION
Erythropoietin
Use of Erythropoietin
HEMATOPOIETIC FACTORS STIMULATING GRANULOCYTE PRODUCTION
Uses
Administration—Dose and Route of Administration, Side Effects
HEMATOPOIETIC FACTORS STIMULATING PLATELET PRODUCTION
CHAPTER 14:
Endocrine Disorders
STRUCTURE
MODE OF ACTION
EVALUATION
INVESTIGATIONS
MANAGEMENT
ANATOMY AND PHYSIOLOGY
DISORDERS OF GROWTH HORMONE
GROWTH HORMONE DEFICIENCY (GHD)
Causes
Diagnosis
Treatment
GIGANTISM AND ACROMEGALY
Diagnosis
Differential Diagnosis
Treatment
DIABETES INSIPIDUS
Etiology
Clinical Features
Diagnosis
Treatment
DEVELOPMENT AND PHYSIOLOGY
HYPOTHYROIDISM
Congenital Hypothyroidism
Acquired Hypothyroidism
Diagnosis
Treatment
Neonatal Screening
HYPERTHYROIDISM
Clinical Features
Investigations
Management
Graves’ Disease
Other Conditions
ADRENAL GLAND
ADRENOCORTICAL EXCESS
Cushing's Syndrome (Glucocorticoid Excess)
Etiology
Clinical Features
Diagnosis
Management
HYPERALDOSTERONISM
ADRENAL INSUFFICIENCY (ADDISON DISEASE)
CONGENITAL ADRENAL HYPERPLASIA
INTRODUCTION
HYPOCALCEMIA
Clinical Features
Etiology
PTH Resistance
Vitamin D Related Hypocalcemia
Evaluation
Management
HYPERCALCEMIA
Clinical Features
Management
REFRACTORY RICKETS
Etiology
Evaluation
Investigations
Management
INTRODUCTION
Classification
Pathogenesis
Clinical Features
Management
Insulin Therapy
Monitoring
Exercise and Physical Activities
Nutrition
Complications
Hypoglycemia
Lipodystrophy
Retinopathy
Nephropathy
Neuropathy
DIABETIC KETOACIDOSIS
Clinical Features
Management
Fluid Therapy
Insulin
Monitoring
INTRODUCTION
Etiology
Evaluation
Complications
Management
INTRODUCTION
PRECOCIOUS PUBERTY
Classification and Etiology
Evaluation
Investigations
Management
Peripheral Precocious Puberty
Central Isosexual Precocious Puberty
Premature Thelarche
Premature Adrenarche
DELAYED PUBERTY
Etiology
Evaluation
Examination
Investigations
Treatment
TURNER'S SYNDROME
Clinical Features
Investigations
Management
PHYSIOLOGY
AMBIGUOUS GENITALIA (HERMAPHRODITISM)
Female Pseudohermaphroditism (FPH)
Male Pseudohermaphroditism (MPH)
True Hermaphroditism (TH)
Evaluation
Investigations
Management
BIBLIOGRAPHY
Short Stature
Growth Hormone Deficiency
Gigantism and Acromegaly
Diabetes Insipidus
Thyroid
Adrenal Gland
Hypocalcemia
Rickets
Diabetes Mellitus
Obesity
Puberty
Sexual Differentiation
CHAPTER 15:
Genetic Disorders
INTRODUCTION
GENETIC DISORDERS
Impact of Genetic Disease
Incidence of Genetic Disease
Prevalence
Medical Genetics
Basic Units of Heredity
STRUCTURE OF DNA
Phosphates and Sugar—deoxyribose
STRUCTURE OF RNA
Mutation
SINGLE GENE (MONOGENIC OR MENDELIAN) DISORDERS
TERMINOLOGIES
PEDIGREE SYMBOLS AND CONSTRUCTION
Autosomal Dominant Traits
Clinical Example
Some Autosomal Dominant Conditions
Autosomal Recessive Traits
Consanguinity (Figure 15.5)
Some Autosomal Recessive Traits
X-linked Inheritance
Some X-linked Recessive Conditions (Figure 15.7)
X-linked Dominant Disorders
Diagnosis of Single Gene Disorders
CHROMOSOMAL DISORDERS
Structure of Chromosome
Number of Chromosomes
Numerical Chromosomal Aberrations
How does Aneuploidy Occur?
Structural Abnormalities of Chromosomes
Microdeletion Syndromes
Duplications
Isochromosomes
Inversions
Translocations (Figure 15.13)
Fragile Sites
Chromosome Breakage Syndromes
Diagnosis of Chromosomal Aberrations
Down's Syndrome
Prenatal Diagnosis
Trisomy 13 – Patau's Syndrome
Trisomy 18 – Edward's Syndrome
Sex Chromosome Aneuploidies
Klinefelter Syndrome — 47 XXY
Turner Syndrome — 45X
POLYGENIC INHERITANCE
NON-TRADITIONAL INHERITANCE
Steps in the Work up of a Patient with Suspected Genetic Disorder
Cancer and Genetics
Some Single Gene Defects with Predisposition to Cancer
Cancer and p53
TREATMENT OF GENETIC DISORDERS
Gene Therapy
Diseases Suitable for Gene Therapy
Strategies
GENETIC COUNSELING
Prerequisites for Proper Genetic Counseling
PREVENTION OF GENETIC DISORDERS AND COMMUNITY GENETICS
CHAPTER 16:
Allergy, Immunodeficiency and Rheumatological Disorders
INTRODUCTION
ALLERGIC RHINITIS
Introduction
Epidemiology
Etiology
Pathophysiology
Clinical Manifestation
Diagnosis
Differential Diagnosis
Management
Avoidance of Allergens
Environmental Control
Pharmacologic Therapy
Immunotherapy
ASTHMA
Introduction
Epidemiology
Etiology and Triggering Factors
Pathophysiology
Clinical Features
Diagnosis
Differential Diagnosis
Complications
Management
Pharmacological Therapy
Treatment of Acute Attack of Asthma
Treatment of Persistent Asthma
Environment Control
Immunotherapy
Prognosis
ATOPIC DERMATITIS
Introduction
Epidemiology
Etiology
Pathophysiology
Clinical Features
Diagnosis
Differential Diagnosis
Complications
Management
Prevention and Follow-up
INTRODUCTION
IMMUNE PATHWAYS
Cells of the Immune System: The T and B Lymphocytes
Lymphocytes and CD Markers
The T-cell Receptor
The Natural Killer (NK) Cells
Cytokines
Non-specific Immune Mechanisms (Humoral)
Complement and Kinin Cascades
Mannan-binding Lectin (MBL)
Interferon (INF)
Iron-binding Proteins
Non-specific Immune Mechanisms (Cellular)
Phagocytosis
Specific Immune Mechanisms
Specific Immune Mechanisms (Humoral or antibody mediated)
Specific Immune Mechanisms (Cellular or T Cell Mediated)
IMMUNODEFICIENCIES
Laboratory Investigation for Suspected Immunodeficiency
Level I Tests (to be performed by the referring Physician)
Level II Tests (to be performed at the referral center)
Level III Tests (to be performed as a research tool)
PRIMARY IMMUNODEFICIENCY DISORDERS
Disorders of Specific Immunity
Cellular and/or Combined Immunodeficiency
Humoral Immunodeficiency
Disorders of Non-specific Immunity
Cellular Immunity Defects
Humoral Immunity Defects
Miscellaneous Immunodeficiency Disorders
Treatment of Primary Immunodeficiencies
INTRAVENOUS IMMUNOGLOBULIN THERAPY
PATIENT EVALUATION
APPROACH TO DIAGNOSIS OF ARTHRITIS IN CHILDREN
JUVENILE RHEUMATOID ARTHRITIS
Etiology
Clinical Features
Pauciarticular JRA
Polyarticular Onset JRA
Systemic Onset JRA
Laboratory Investigations
Treatment
Medical Therapy
Course of Illness
SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
Diagnosis of SLE
Treatment
ANTI-PHOSPHOLIPID ANTIBODY SYNDROME (APLA SYNDROME)
JUVENILE DERMATOMYOSITIS
Clinical Features
Treatment
SCLERODERMA
VASCULITIDES IN CHILDREN
TAKAYASU'S ARTERITIS
KAWASAKI DISEASE
POLYARTERITIS NODOSA (PAN)
Major Criteria
Minor Criteria
HENOCH-SCHӦNLEIN PURPURA (HSP)
Diagnosis
Treatment
BIBLIOGRAPHY
Allergic Rhinitis
Asthma
Atopic Dermatitis
Immunology
Immunodeficiencies
Intravenous Immunoglobulin Therapy
Approach to Diagnosis of Arthritis in Children
Systemic Lupus Erythematosus
Antiphospholipid Antibody Syndrome
Juvenile Dermatomyositis
Scleroderma
Vasculitidis in Children
Takayasu's Arteritis
Kawasaki Disease
Polyarteritis Nodosa (PAN)
Henoch-Schönlein Purpura (HSP)
CHAPTER 17:
Adolescent Care
INTRODUCTION
INITIATION OF PUBERTY
CHANGES OCCURRING IN PUBERTY
Psychosocial Development
ADOLESCENT NUTRITION
Disorders of Growth
ENDOCRINE ISSUES
MEDICAL ISSUES
REPRODUCTIVE HEALTH ISSUES
Sexuality
MENTAL HEALTH ISSUES
SUBSTANCE ABUSE
MEDIA INFLUENCE
BODY IMAGE
INTERVENTIONS
CHAPTER 18:
Poisoning and Toxic Ingestion
INTRODUCTION
House Hold Substances
Medicines
General Guidelines on Management of Poisoning
THINK OF POISONING
Removal of the Source of Poison and Shifting the Patient
Stabilization of Patient with First Aid Measures
Identify the Poison
Quantification of the Poison
Symptomatic and Supportive Measures
Prevention of Continued Absorption of Poison
Enhancement of Elimination of Poison
Administration of Antidotes
LEAD POISONING
Sources of Lead
Pathophysiology
Symptomatology
Clinical Examination
Investigations
Treatment
Prognosis
Prevention
HYDROCARBON POISONING
Pathophysiology
Clinical Manifestations
Complications
Investigations
Management
Criteria for Discharge
Prevention
IRON POISONING
Pathophysiology
Phase I
Phase II
Phase III
Phase IV
Phase V
Investigations
Treatment
BARBITURATE POISONING
Pathophysiology
Clinical Features
Investigations
Treatment
SALICYLATE POISONING
Pathophysiology
Clinical Features
Complications of Salicylate Poisoning
Investigations
Management
CORROSIVE POISONING
Pathophysiology
Clinical Features
Complications
Investigations
Management
PARACETAMOL POISONING
Pathophysiology
Clinical Features
Diagnosis
Management
ORGANOPHOSPHORUS POISONING
Pathophysiology
Clinical Manifestations
Investigations
Management
PREVENTION OF POISONING
MEDICOLEGAL ASPECTS
Some General Guidelines for Safety Regarding Accidental Poisoning
Information to be given to Poison Control Center
ENVENOMATION
Snake Bite
Pathogenesis
Clinical Manifestations
Severity of Envenomation
Investigations
Complications
Treatment
Scorpion Sting
Pathophysiology
Clinical Features
Investigations
Treatment
Preventive Measures
Bee Sting
CHAPTER 19:
Communication Disorders
INTRODUCTION
MAGNITUDE OF THE PROBLEM
COMMUNICATION, SPEECH AND LANGUAGE
Characteristics of Language
Pre-requisites for Normal Development of Speech and Language
Milestones in Speech and Language Development
Speech and Language Disorders
Articulation Diorders
Fluency Disorders
Voice Disorders
Language Disorders
Developmental Language Disorders
Disorders that Impact Language Development
Assessment of Language Disorders
Intervention for Language Disorders
HEARING DISORDERS
Early Identification of Hearing Loss
Confirmation of Hearing Loss
Current Approaches to the Assessment of Hearing in Children
Techniques to Establish Threshold of Hearing
Behavioral Observation Audiometry (BOA)
Classification of Hearing Loss
Other Techniques to Assess the Auditory System
Immittance Evaluation
Otoacoustic Emissions
Auditory Brainstem Response or BERA/ABR
Auditory Steady State Response
Intervention
Prevention of Hearing Loss
MANAGEMENT OF COMMUNICATION DISORDERS IN CHILDREN
CHAPTER 20:
Child Abuse and Neglect, Child Labor, and Child Adoption
INTRODUCTION
FORMS OF CHILD ABUSE
INCIDENCE
RECOGNITION OF CHILD ABUSE
INVESTIGATIONS
MANAGEMENT GUIDELINES
INTRODUCTION
DEFINITION
HOW MANY IN INDIA?
CAUSES OF CHILD LABOR
FORMS OF CHILD LABOR
Occupational Health Hazards in Agriculture
Industries and Factories
Nonorganized and Service Sectors
Special Groups of Child Labor
SOCIOECONOMIC IMPLICATIONS OF CHILD LABOR
Child Labor > No Education > Unskilled Jobs
ELIMINATION OF CHILD LABOR
WHY DOES A PEDIATRICIAN NEED TO KNOW AND UNDER– STAND THE CONCEPT AND PROCESS OF CHILD ADOPTION?
WHAT IS ADOPTION?
Historical Overview
Adoption of Indian Minors – Present Scenario
Order of Priority
Adoptive Infants/Children
Prospective Adoption Parents (PAP)
IMPORTANT DOCUMENTS TO BE PREPARED BY SOCIAL WORKERS
Home Study Report
Child Study Report
Various Agencies Involved in Adoption and their Functions
Central Adoption Resource Agency (CARA)
Licensed Adoption Placement Agencies (LAPA) for In-Country Adoption
Recognized Indian Placement Agencies for Inter-Country Adoption (RIPA)
Voluntary Co-ordinating Agency (VCA)/Adoption Coordinating Agency (ACA)
Foreign Sponsoring Agency
Role of Central Government
Role of the State Governments
Adoption Scrutinizing Agency
SALIENT FEATURES OF HAMA
Who may Adopt?
Who maybe Adopted?
Who may Give a Child in Adoption
Other Conditions
The Guardian and Wards Act, 1890
Procedure for In-Country Adoption
Procedure for Inter-Country Adoption
BIBLIOGRAPHY
Child Abuse and Neglect
Child Labor
Child Adoption
REPORTS
CHAPTER 21:
Skin Diseases in Children
STRUCTURE AND FUNCTIONS OF SKIN
INFECTIONS AND INFESTATIONS
Parasitic Infestations
Scabies
Pediculosis Capitis
Papular Urticaria
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.4 and 21.5)
Treatment
Bacterial Infections
Impetigo Contagiosa
Bullous Impetigo
Cellulitis
Skin findings:
Erysipelas
Furuncles and Carbuncles
Viral Infections
Herpes Zoster
Molluscum Contagiosum
Viral Warts
Pityriasis Rosea
Fungal Infections
Tinea Capitis
Pityriasis Versicolor
DERMATITIS AND ECZEMAS
Atopic Dermatitis
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.23 and 21.24)
Special Features
Investigations/Dermatopathology
Treatment
Seborrheic Dermatitis
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figure 21.25)
Investigations/Dermatopathology
Treatment
Napkin Dermatitis
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.26 and 21.27)
Treatment
DISEASES OF HAIR, SEBACEOUS AND SWEAT GLANDS
Alopecia Areata
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.28 and 21.29)
Investigations/Dermatopathology
Treatment
Acne Vulgaris
Definition/Description
Epidemiology/Etiology
Clinical evaluation (Figures 21.30 and 21.31)
Treatment
Miliaria Rubra (Prickly Heat)
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.32 and 21.33)
Treatment
URTICARIA AND FIXED DRUG REACTIONS
Urticaria and Angioedema
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.34 and 21.35)
Investigations/Dermatopathology
Treatment
Fixed Drug Eruption
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.36 and 21.37)
Investigations/Dermatopathology
Treatment
PAPULOSQUAMOUS DISORDERS
Psoriasis
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.38 and 21.39)
Investigations/Dermatopathology
Treatment
Lichen Planus
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.40 to 21.42)
Investigations/Dermatopathology
Treatment
GENETIC DISORDERS
Ichthyosis Vulgaris
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.43 and 21.44)
Treatment
Collodion Baby
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.45 to 21.47)
Treatment
PIGMENTARY DISORDERS
Vitiligo
Definition/Description
Epidemiology/Etiology
Clinical Evaluation (Figures 21.48 and 21.49)
Investigations/Dermatopathology
Treatment
Pityriasis Alba
Definition/Description
Epidemiology/Etiology
Clinical Features (Figure 21.50)
Investigations/Dermatopathology
Treatment
CHAPTER 22:
Common Eye, Ear, Nose, Throat and Dental Problems in Children
INTRODUCTION
RETINOPATHY OF PREMATURITY
OPHTHALMIA NEONATORUM
CONGENITAL NASOLACRIMAL DUCT OBSTRUCTION
CONGENITAL GLAUCOMA
CONGENITAL CATARACT
STRABISMUS
AMBLYOPIA
LEUKOCORIA
CHILD WITH POOR VISION
UVEITIS
NYSTAGMUS
REFRACTIVE ERRORS
OCULAR TRAUMA
WHEN SHOULD A PEDIATRICIAN REFER A CHILD TO THE OPHTHALMOLOGIST?
OTOLOGICAL PROBLEMS
PROBLEMS OF OTORRHEA
External Ear
Foreign Bodies in the Ear
Treatment
RUPTURED TYMPANIC MEMBRANE
OTITIS MEDIA
Acute Suppurative/Chronic Suppurative/Acute Secretory/Chronic Secretory
Acute Suppurative Otitis Media in Infant (ASOM)
Adenoid Hypertrophy and Infection
Teething and Otitis Media
Acute Otitis Media in Infants and Acute Gastroenteritis
Clinical Variants in Acute Otitis Media
Signs of Acute Otitis Media
Bacteriology
Treatment
Recurrent Otitis Media/Chronic Suppurative Otitis Media (CSOM)
Management of Chronic Otitis Media
Complications
Pathways of Extension
Osteothrombophlebitis
Facial Palsy
Petrositis
Meningitis
Brain Abscess
Otitic Hydrocephalus
Tuberculous Otitis and Mastoiditis
Nonsuppurative Otitis Media—Acute and Chronic
Acute
Chronic Secretory Otitis Media
NOSE, THROAT AND SINUS PROBLEMS
Nasal and Sinus Diseases
Choanal Atresia
Epistaxis
Treatment
Sinuses
THROAT DISORDERS
Acute Retropharyngeal Abscess
Ludwig's Angina
Faucial Diphtheria
Foreign Bodies
Burns
LARYNX
Laryngismus Stridulus
Laryngeal Injuries
Foreign Bodies
Paralytic Lesion
Laryngeal Diphtheria
ENT EMERGENCIES
Laryngeal Obstruction in Children
SUPRAGLOTTIC CAUSES
Peritonsillar Abscess
Retropharyngeal Abscess
Lateral Pharyngeal Space Infection
Foreign Body
Ludwig's Angina
Nasopharyngeal Dermoid Cyst
Choanal Atresia
Angioneurotic Edema
GLOTTIC CAUSES
Congenital Laryngeal Stridor
Epiglottis and Laryngitis
Growths
Tetanus
Tetany
Laryngeal Webs
SUBGLOTTIC CAUSES
LARYNGOTRACHEOBRONCHITIS
BRONCHOSCOPY IN INFANTS AND CHILDREN
Aspiration of Milk
Foreign Body in the Tracheobronchus
SPEECH PATHOLOGY AND AUDIOLOGY IN PEDIATRICS
Stammering
Dyslalia
Impact of Congenital and Neurological Anomalies in Speech and Hearing Problems
Hearing tests in Children
Audiogram
Behavioral Observation Audiometry (BOA)
Congenital Deafness
Infantile Aphasis or Developmental Aphasis
Dysarthria
Mental Retardation with Speech Problems
Autism
INTRODUCTION
PRIMARY DENTITION
Development of Teeth
Functions of Teeth
Physiological Events Causing Pain
Pre-eruption Bulge
Eruption Hematoma
DENTAL CARIES
ETIOPATHOGENESIS
CLASSIFICATION
Smooth Surface Caries
Pit and Fissure Caries
Rampant Caries
Clinical Manifestations
NURSING BOTTLE CARIES
Etiological Factors
Complications
Treatment
Management of Dental Caries
Oral Candidiasis
NECROTIZING ULCERATIVE GINGIVITIS
CHRONIC GINGIVAL DISEASES
Chronic Marginal Gingivitis
Papillon-Lefèvre Syndrome
MALOCCLUSION
INJURIES OF THE TEETH
Management
PREVENTION
CHAPTER 23:
Pediatric Surgery sand Orthopedics
INTRODUCTION
REFERRAL FOR DIAGNOSIS
TIMING OF SURGERY
EMERGENCY GROUP
Neonatal Emergencies (Figures 23.1 to 23.16)
SEMI EMERGENCY GROUP
INTERMEDIATE GROUP
ELECTIVE GROUP
INTRODUCTION
FRACTURES IN CHILDREN
Birth Fractures
Fracture Shaft of Femur
Fracture Shaft of Humerus
Fracture Clavicle
Battered Baby Syndrome
Epiphyseal Injuries
OTHER COMMON FRACTURES
Fracture Clavicle
Nature of Violence
Clinical Features
Diagnosis
Treatment
Complications
Supracondylar Fracture
Incidence and Mechanism
Types of Fracture
Clinical Features
Radiological Features
Treatment
Complications
Fracture of the Forearm
CONGENITAL DEFORMITIES
LOWER LIMB
Congenital Talipes Equinovarus (CTEV, Club Foot)
Etiology
Pathological Anatomy
Clinical Features
Differential Diagnosis
Radiography—CTEV
Principles of Treatment
Conservative Treatment
Maintenance of Correction
Surgical Treatment
Neglected Club Foot
DEVELOPMENTAL DYSPLASIA OF THE HIP (DDH)
Congenital Genu Recurvatum
UPPER LIMB
Sprengel's Shoulder
Congenital Radioulnar Synostosis
Madelung's Deformity
Syndactylism
Polydactylism
CARTILAGINOUS DYSPLASIAS
Multiple Exostoses (Diaphyseal Achalasia)
Clinical Features
Pathology
Complications
Radiological Features
Treatment
Enchondromatosis (Ollier's Disease)
Clinical Features
Radiological Features
Treatment
BONE DYSPLASIAS
Osteogenesis Imperfecta
Clinical Features
Radiological Features
Treatment
Osteopetrosis (Marble Bone Disease, Albers Schonberg Disease)
Clinical Features
Radiological Features
Treatment
Fibrous Dysplasia
Clinical Features
Radiological Features
Laboratory Findings
Biopsy
Treatment
Congenital Pseudoarthrosis of the Tibia
Classification
Clinical Features
Radiological Features
Treatment
OSTEOMYELITIS
Pyogenic Osteomyelitis
Clinical Types
Pathology
Clinical Features
Differential Diagnosis
Radiological Features
Laboratory Findings
Treatment
Complications of Acute Osteomyelitis
Chronic Osteomyelitis
Etiology
Pathology
Clinical Features
Radiological Features
General Management
Surgical Management
Complications
INTRODUCTION
ACUTE PYOGENIC (SEPTIC) ARTHRITIS
Pathology
Clinical Features
Radiological Features
Laboratory Findings
Differential Diagnosis
Treatment
Conservative Treatment
Surgical Treatment
SEPTIC ARTHRITIS OF INFANCY (TOM SMITH'S ARTHRITIS)
Delayed Presentation
BIBLIOGRAPHY
Pediatric Surgery
CHAPTER 24:
Medical research
INTRODUCTION
POSSIBLE EXPLANATIONS FOR CLINICAL OBSERVATIONS
RESEARCH STUDY DESIGNS
Randomized Controlled Clinical Trial (RCT)
Advantages of RCT
Disadvantages of RCT
Cohort (Non-equivalent) Group, Concurrent Study
Study Design
Advantages
Disadvantages
Case Control Study
Study Design
Advantages
Cross Sectional Survey
Advantages
Disadvantages
Descriptive Study
Advantages
Disadvantages
CRITICAL APPRAISAL OF CLINICAL EVIDENCES: CONCEPTS AND APPLICATIONS
CHAPTER 25:
Rational Drug Therapy
INTRODUCTION
DEFINITION OF RATIONAL DRUG USE
PRINCIPLES OF RATIONAL DRUG THERAPY
IRRATIONAL USE OF DRUGS
Factors Influencing Irrational use of Drugs
Impact of Irrational use of Drugs
MENINGITIS
Acute Bacterial Meningitis
RESPIRATORY TRACT INFECTIONS
Acute Rhinosinusitis
Treatment
WHO Recommendations for Simple Cough or Cold or Sore Throat
Acute Pharyngitis
Treatment
Acute Otitis Externa
Acute Otitis Media
Recurrent Otitis Media and Otitis Media with Effusion
Acute Bronchiolitis
Acute Laryngotracheobronchitis
Pneumonia
Treatment
GASTROINTESTINAL INFECTIONS
Diarrhea
Definition
What is not Diarrhea?
Types
Risk Factors
Treatment
Drugs—No role
Nutritional Management
URINARY TRACT INFECTIONS
Lower Urinary Tract Infection/Acute Cystitis
Duration of Treatment
Upper Urinary Tract Infection/Acute Pyelonephritis Antibiotics in Order of Preference
Duration of Therapy
BACTERIAL SKIN INFECTIONS
Impetigo
Ecthyma
Blistering Dactylitis
Folliculitis
Furunculosis and Carbuncles
Cellulitis and Erysipelas
Perianal Streptococcal Dermatitis
Necrotizing Fasciitis
Staphylococcal Scalded Skin Syndrome
TOXIC SHOCK SYNDROME
CHAPTER 26:
Pediatric procedures
INTRODUCTION
GENERAL PRECAUTIONS
INTRAMUSCULAR INJECTION
Method
Note
SUBCUTANEOUS INJECTION
Method
INTRADERMAL INJECTION
Method
RECTAL ADMINISTRATION OF DRUGS
PERIPHERAL VENIPUNCTURE
Method
INTRAVENOUS CANNULATION
Method
Note
VENOUS CUT-DOWN
Method
INTRA-OSSEOUS ACCESS
UMBILICAL VEIN CATHETERIZATION
Method
Note
BONE MARROW ASPIRATION
Method
Note
LUMBAR PUNCTURE
Method
Note
NASOGASTRIC TUBE INSERTION
Method
Note
ABDOMINAL PARACENTESIS
Method
SUPRA-PUBIC BLADDER ASPIRATION
Method
THORACOCENTESIS
Method
Note
CHAPTER 27:
Annexures
MORTALITY, FERTILITY, AND OTHER HEALTH INDICATORS
NATIONAL POPULATION POLICY
AMINOGLYCOSIDES
PENICILLIN
MODIFIED PENICILLINS
CEPHALOSPORINS
MACROLIDES AND RELATED DRUGS
FLUOROQUINOLONES
CHEMOTHERAPEUTICS
SYSTEMIC PROTOZOAN INFECTION
CARDIOVASCULAR DRUGS
ASTHMA
NON STEROIDAL ANTI-INFLAMMATIORY DRUG
ANTIHISTAMINICS
TRANQUILIZERS
OTHER DRUGS WITH DIFFERENT INDICATIONS
INTRODUCTION
INVESTIGATIONS
BASIC INVESTIGATIONS
Blood
Red Cell Indices
WBC
Platelet Count
Peripheral Smear
Urine
Color of Urine
Smell of Urine
Deposits
Special investigations in urine:
Motion
Sputum Examination
CSF Examination
Commonly done Biochemical Investigations
S. Electrolytes
AST, ALT
SAP
INTRODUCTION
Definitions and Measurements (Table 27.10)
Severe Acidosis can Produce
Blood Gas Analysis
Acid-Base Regulation
Normal Process
Buffer system
ACIDOSIS AND ALKALOSIS
CONCLUSION
BIBLIOGRAPHY
INTRODUCTION
PROBLEM STATEMENT
GENERAL PRACTICAL ASPECTS OF INJECTION PRACTICES
EQUIPMENT NEEDED FOR SAFE INJECTION PRACTICES
SITE OF INJECTION
Size of Needles Recommended as per IAP ACIP Guidelines
CONCLUSION
BIBLIOGRAPHY
I. TRAINING
II. SKILLS
III THEORY AND PRACTICALS
IV. EXAMINATION
Part II
V. INTERNSHIP
EVALUATION
GUIDELINES FOR CLINICAL AND VIVA
MARKS QUALIFYING FOR A PASS
Source
INDEX
TOC
Index
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