Embryo Transfer
EDITOR
Gautam N Allahbadia MD DNB FNAMS FCPS DGO DFP FICMU FICOG
Scientific Director
The Prince Aly Khan Hospital IVF Center and The Aesculap Academy-Asia Pacific Center for Minimally Invasive Surgery Training and Research Mazgaon, Mumbai (India) Medical Director Rotunda - The Center for Human Reproduction
Bandra, Mumbai(India)
EDITORIAL ASSISTANT
Rubina Merchant PhD
Embryologist Rotunda - The Center for Human Reproduction Bandra,
Mumbai(India)
Jitendar P Vij
Jaypee Brothers Medical Publishers (P) Ltd
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Embryo Transfer
© 2008, Jaypee Brothers Medical Publishers
All rights reserved. No part of this publication should be reproduced, stored in a retrieval system, or transmitted in any form or by any means: electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the editor and the publisher.
First Edition 2008
9788184480924
Typeset at JPBMP typesetting unit
Printed at Ajanta
4Dedicated to
my wife Swati
5Acknowledgements
“Do not save your loving speeches
For your friends till they are dead;
Do not write them on their tombstones,
Speak them rather now instead.“
– Anna Cummins
I would like to acknowledge the brainstorming and encouragement for this project from a brilliant mind from Finland-Candido Tomas.
10Foreword
The monograph entitled Embryo Transfer, edited by Dr Gautam N Allahbadia, is a unique effort, which compiles comprehensive information on a large number of practical points related to this final, yet crucial step of embryo transfer (ET) in the assisted reproductive technology (ART) procedure.
There is no disagreement on the point that the embryo transfer procedure is not always as simple as it is presumed to be by many clinicians. The embryo transfer technique, apart from embryo quality and endometrial receptivity, is one of the basic factors, which will determine the final outcome of an IVF treatment cycle. The relevance of the embryo transfer technique on the success rate of IVF has not been adequately described in the published literature. However, it has been estimated that at least 30% of failure in ART is due to poor performance in the procedure of embryo transfer.
A faulty technique of embryo replacement is known to have a negative impact on IVF outcome. These negative impacts can be avoided to a certain extent by improvised and modified approaches. However, in few circumstances, such as, embryo expulsion immediately after transfer, presence of cervical mucus and the so-called ‘difficult cervix’, the negative impact is difficult to avoid.
Various authors report an embryo expulsion rate of approximately 45 to 50% following embryo transfer. Uterine contractions during the ET procedure is one of the major factors responsible for embryo expulsion. This problem can, to some extent, be avoided. Various techniques can be employed to minimize embryo expulsion due to uterine irritability at the time of ET. These techniques have been elaborately dealt with in different chapters of the book. Experience is essential to perform an efficient ET and this may, to a large extent, prevent embryo expulsion.
In some cases, cervical mucus may interfere with an effective ET. Removal of the cervical mucus by flushing with normal saline or media has remained controversial. These controversies have been covered in the chapter dealing with mucus, blood and retention of embryos. In about 10% of the cases, ET becomes difficult due to a ‘difficult cervix’, more commonly, due to acute anteflexion or anteversion, and less frequently, due to anatomical distortion, previous surgery or congenital anomalies.
The ideal catheter for embryo transfer has been described. Proper evaluation of the uterine cavity before starting an IVF cycle, USG measurement of the uterine cavity length, cervical canal, assessment of the uterocervical angle, and a mock transfer before actual ET may improve the embryo transfer performance. These points have been adequately dealt in respective chapters.
Proper loading of the ET catheter is important. The significance of the columns of culture media and air bubbles within the ET catheter has been properly illustrated. The location of embryos within the uterine cavity after embryo replacement, which may have an impact on implantation rate or the incidence of ectopic pregnancy, has been discussed.
Embryo transfer by the ‘clinical touch’ technique or under USG guidance depends on clinician's experience. Most of the publications have reported improved pregnancy rate following embryo transfer under USG guidance. Under critical situations, maneuvers such as, embryo transfer with a full bladder and speculum maneuvering in order to bring the cervicouterine angulation in a straight line, have been described in detail. Under desperate circumstances, transmyometrial ET has been suggested, although the pregnancy rate is very low or practically nil in such cases.
The editor has also included chapters on newer thoughts about embryo transfer like hysteroscopic tubal embryo transfer, endoscopic intra- endometrial ET, and syringeless embryo transfer in addition to the requirement and impact of early ambulation versus rest and relaxation following embryo transfer.
Having discussed all the technical aspects, the editor finally concludes with a chapter that indicates that the art and skill of embryo transfer should be based on a sound platform of scientific knowledge. This wonderful and informative monograph will be of immense help to all those who are practicing ART, and especially, clinicians who face problems in their everyday practice of embryo replacement.
BN Chakravarty
12Preface
“Good communication is as stimulating as black coffee, and just as hard to sleep after.”
– Anne Morrow Lindbergh
In this new book, we have drawn on our own clinical experience of infertility and have also brought together the work of some of the foremost authorities whose collective passion is improving implantation rates by refining the technique of Embryo Transfer. I assure you that you will examine your own practice in a different perspective after these stimulating opinions from world leaders in the field. I strongly believe that the procedure of embryo transfer is the rate-limiting step in assisted reproduction. Fifteen years of my clinical practice have been focused on improving the embryo transfer technique and in research in the subject. Many women undergoing an assisted reproductive technology (ART) cycle will never achieve a live birth. Failure at the embryo transfer stage may be due to poor embryo quality, lack of uterine receptivity, or the transfer technique itself. Numerous methods, including the use of ultrasound guidance for proper catheter placement in the endometrial cavity, have been suggested as a means of improving the technique of embryo transfer. I strongly believe that the use of ultrasound, and more so, after the introduction of the soft ultrasonic SureView™ catheters, has greatly impacted clinical results the world over. The introduction of ultrasound into the embryo transfer procedure will be regarded as one of the landmarks of ART in the years to come. The old guard still resists acknowledging ultrasound- guided embryo transfers and is clinging onto the ‘Clinical Touch’ method despite mounting evidence in literature to the contrary. This book has very practical information, which translates into the best contemporary practices for the patient needing an embryo transfer.
“A friend is someone who knows the song in your heart, and can sing it back to you when you have forgotten the words.”
– Donna Roberts
A lot of ideas that have gone into the book- listening to friends like Hassan Sallam and Ragaa Mansour from Egypt. I was always hungry for knowledge pertaining to embryo transfers and would like to acknowledge my lengthy discussions over the years with Adrian Shulman, Ariel Weissman, Ilan Tur-Kaspa and Danny Seidman from Israel. I remember many of these discussions beginning in hospital during working hours and spilling over into the early hours of morning at restaurants and pubs in Tel Aviv!
I hope you enjoy reading this monograph, which is truly a culmination of ART, science and passion.
Gautam N Allahbadia
13List of Contributors
- Ahmed Mohammed Abou-Setta md
- The Egyptian IVF-ET Center
- Cairo
- Egypt
- Abbas Aflatoonian md
- Head Yazd Research and Clinical Center for Infertility
- Department of Obstetrics and Gynecology, Yazd
- Iran
- Gautam N Allahbadia md, dnb
- FNAMS, FCPS, DGO, DFP, FICMU, FICOG
- Scientific Director
- The Prince Aly Khan Hospital IVF Center and The Aesculap Academy-Asia Pacific Center For Minimally Invasive Surgery, Training and Research
- Mazgaon, Mumbai
- Medical Director Rotunda - The Center For Human Reproduction
- Bandra, Mumbai
- India
- Manuel Alvarez md
- Gynecologist Service of Reproductive Medicine
- Department of Reproductive Medicine, Obstetrics and Gynecology (RMO and G)
- Instituto Universitario Dexeus
- Barcelona
- Spain
- Claus Yding Andersen msc, dmsc
- Senior Researcher
- Laboratory of Reproductive Biology Rigshospitalet
- The Juliane Marie Center of Women
- Children and Reproduction Blegdamsvej
- University Hospital of Copenhagen
- Copenhagen
- Denmark
- Robert E Anderson md, facog
- Director, Southern California
- Center for Reproductive Medicine Medical Director, Southern California Institute for Reproductive Sciences
- Southern California Center for Reproductive Medicine
- Newport Beach
- California
- USA
- Sulbha Arora md, dnb
- Clinical Associate
- Rotunda - The Center For Human Reproduction
- Bandra, Mumbai
- The Prince Aly Khan Hospital IVF
- Center, Aesculap Academy - Asia Pacific Center For Minimally Invasive Surgery Training and Research
- Mazagaon
- Mumbai
- India
- Maryam Asgharnia md
- Research And Clinical Center For Infertility
- Shahid Sadoughi University
- Yazd Medical Sciences University
- Iran
- Umesh Athavale md (radiology)
- Radiologist and Sonologist
- The Prince Aly Khan Hospital IVF
- Center and The Aesculap
- Academy-Asia Pacific Center For Minimally Invasive Surgery Training and Research
- Mazgaon, Mumbai
- India
- Ramon Aurell md
- Gynecologist Service of Reproductive Medicine
- Department of Reproductive Medicine, Obstetrics and Gynecology (RMO and G)Instituto Universitario Dexeus
- Barcelona
- Spain
- Anjali Awasthi msc
- Laboratory Director Dr LH Hiranandani Center for Human Reproduction
- Dr LH Hiranandani Hospital
- Powai, Mumbai
- India
- Balázs Balyi phd
- Embryologist and Molecular Biologist
- Head of the Embryology Laboratory of Nyiro Gyula Hospital
- Department of Infertility and Assisted Reproductive Techniques Reproductive Endoscopic Surgery
- Budapest
- Hungary
- Pere Nolasc Barri md
- Gynecologist
- Head of the Department
- Service of Reproductive Medicine
- Department of Reproductive Medicine, Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Barcelona
- Spain
- Ricardo Luiz Razera Baruffi md
- Gynecologist
- Center for Human Reproduction
- Prof. Franco Junior Alto da Boa Vista
- Brazil
- Joel Batzofin md
- Medical Director
- SIRM-NewYork
- NewYork
- USA
- Micha Baum md
- Senior Physician, IVF Unit, Department of Obstetrics and Gynecology
- The Chaim Sheba Medical Center Tel-Hashomer and Sackler Faculty of Medicine,
- Tel-Aviv University, Tel-Aviv
- Israel
- Aykut Bayrak md, facog
- Associate Physician
- SIRM-NewYork
- NewYork
- USA
- Wolfgang Biasio phd
- Head of Laboratory
- Private Kinderwunsch-Clinic Dr J Zech GmbH, Grabenweg
- Innsbruck
- Austria
- Montserrat Boada md
- Service of Reproductive Medicine
- Department of Reproductive Medicine Obstetrics and Gynecology (RMO and G)
- Instituto Universitario Dexeus
- Barcelona
- Spain
- Rosario Buxaderas md
- Gynecologist
- Service of Reproductive Medicine
- Department of Reproductive Medicine
- Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Barcelona
- Spain
- Olga Carreras md
- Radiologist
- Service of Reproductive Medicine
- Department of Reproductive Medicine
- Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Barcelona
- Spain
- Priya A Chauhan md
- Consultant Obstetrician and Gynecologist
- The Fertility Clinic Julian Marie Center
- Rigs Hospital Copenhagen University
- Copenhagen
- Denmark
- Christopher Chen md (honoris causa), fams, frcog, fracog, franzcog, facs, fics
- CEO and Medical Director
- Christopher Chen Centre for Reproductive Medicine, Senior Consultant Obstetrician and Gynecologist and Infertility Specialist
- Director of Gleneagles IVF Center Gleneagles Hospital
- Singapore
- Buenaventura Coroleu md
- Gynecologist and Head Service of Reproductive Medicine
- Department of Reproductive Medicine Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Barcelona
- Spain
- Michael F Costello mmed, franzcog,
- CREI
- Senior Lecturer in Obstetrics and Gynecology School of Women's and Children's Health, Division of Obstetrics and Gynecology
- Royal Hospital for Women
- Sydney
- Australia
- Christoph Dorn md
- Gynecologist
- Department of Endocrinology and Reproductive Medicine
- University of Bonn
- Bonn
- Germany
- Thomas Ebner md
- Associate Professor in Reproductive Biology
- Embryologist (Landes-Frauen-und Kinderklinik Linz, Austria)
- IVF-Unit
- University of Salzburg
- Austria
- Antonia Expósito md
- Embryologist
- Human Reproduction Unit
- Department of Obstetrics and Gynecology, Hospital de Cruces
- Basque Country University
- Bilbao
- Spain
- Rene Frydman md
- Professor and Head
- Department of Obstetrics and Gynecology
- Hôpital Antoine BéclèreService de Gynécologie Obstétrique
- Clamart
- France
- Goral Gandhi msc
- Laboratory Director
- Rotunda-The Center For Human Reproduction
- Bandra, Mumbai
- India
- Uma Deve Gordon md, frcog
- Specialist in Reproductive Medicine
- Consultant Senior Lecturer
- Center for Reproductive Medicine
- University of Bristol
- Clifton
- Bristol
- UK
- Antonio Gutiérrez md
- Vida Institute of Human Reproductive Sciences
- Hospital de Especialidades Puerta de Hierro, Guadalajara
- México
- Guadalupe Gutiérrez md
- Instituto Vida
- Hospital de Especialidades Puerta de Hierro, Guadalajara
- México
- Lars Hamberger phd, md
- Professor Emeritus in Obstetrics and Gynecology
- Göteborg University, Göteborg Sweden
- Adress Sahlgrens University Hospital
- Göteborg
- Sweden
- Thorir Hardarson phd
- Laboratory Director Fertility Center
- Gothenburg
- Sweden
- Itai Bar-Hava md
- Obstetrics, Gynecology Ultrasound and Fertility Specialist
- Department of Obstetrics and Gynecology
- The Edith Wolfson Medical Center
- Holon
- Israel
- Johan T Hazekamp md
- Consultant Gynecologist
- The Department for Reproductive Medicine
- Volvat Medical Center, Oslo
- Norway
- Bernd Hinney md,
- DMProfessor and Head
- Reproductive Medicine Study Group
- Executive Assistant Medical Director
- Department of Obstetrics and Gynecology
- University of Goettingen Faculty of Medicine
- Goettingen
- Germany
- Peter Humaidan md
- Consultant
- The Fertility Clinic
- Sygehus Viborg
- Skive Sygehus
- Denmark
- Hesham Al-Inany md, phd
- Assistant Professor
- Department of Obstetrics and Gynecology
- Faculty of Medicine Cairo University
- IVF consultant
- The Egyptian IVF-ET center
- Cairo, Egypt
- Pieraldo Inaudi md, phd
- Professor in Reproductive Medicine
- Department of Pediatrics Obstetrics and Reproductive Medicine School of Medicine
- University of Siena Scientific and Clinical Director
- Siena Fertility Center Via S Pertini 7 (Loc. Montarioso)
- Monteriggioni (Siena Nord)
- Italy
- Eugenia Isachenko phd
- Reproductive Biologist
- Department of Endocrinology and Reproductive Medicine
- University of Bonn
- Bonn
- Germany
- Padma Rekha Jirge mbbs, mrcog
- Scientific Director
- Sushrut - Assisted Conception
- Kolhapur
- India
- José GonCalves Franco Junior md, phd
- Scientific Director
- Center for Human Reproduction Prof. Franco JuniorExecutive Director of the Latin America Network of AssistedReproduction
- Center for Human Reproduction Prof. Franco JuniorAlto da Boa VistaBrazil
- Kaushal Kadam md
- Scientific Director Rotunda - The Center For Human Reproduction
- Bandra, Mumbai
- India
- Chandra Kailasam md, msc, mrcog
- Specialist in Reproductive Medicine
- Center for Reproductive Medicine
- University of Bristol Clifton
- Bristol
- UK
- Michael Kamrava md
- Clinical Instructor
- Department of Obstetrics and Gynecology
- David Geffen School of Medicine
- University of CaliforniaLos Angeles
- Cedars Sinai Medical Center
- Department of Obstetrics and Gynecology Medical and Laboratory Director
- West Coast IVF Clinic, Inc. Los Angeles Center for Embryo Implantation (SEED)
- Los Angeles,
- California
- USA
- Vishvanath C Karande md, facog
- President, Medical Director Assisted Reproductive Technologies Program Karande and Associates Director, In Vitro Fertilization Program
- Center for Human Reproduction Hoffman Estates
- Chicago, Illinois
- USA
- Christoph Keck md, phd
- Assistant Professor
- Medical Director Reproductive Health Serono International
- Geneva
- Switzerland
- Seiji Kitamura mdchief
- Department of Obstetrics and Gynecology Ogikubo Hospital
- Tokyo
- Japan
- Sigal Klipstein md, facog
- Specialist in Reproductive Endocrinology and Infertility
- Karande and Associates Hoffman Estates
- Chicago, Illinois
- USA
- Gabor T Kovacs md, frcog, franzcog, crei
- Medical Director
- Monash IVF
- Monash Medical School
- Monash University
- Department of Obstetrics and Gynecology Box Hill Hospital
- Melbourne
- Australia
- Jothi Kumar mmed (o and g), frcog,
- PhD, FAMS
- Consultant Obstetrician and Gynecologist
- Obstetrician and Gynecologist Partners, Clinic for Women
- Obstetrician and Gynecologist Partners, Fertility Center
- Gleneagles Hospital
- Singapore
- Amruta Kumthekar msc
- Embryologist
- Rotunda - The Center For Human Reproduction
- Bandra, Mumbai
- India
- Hovey Lambert phd
- West Coast IVF Clinic, Inc.
- Los Angeles Center for Embryo Implantation (SEED)
- Los Angeles, California
- USA
- Susan Lenz md, dmsci
- Obstetrician and Gynecologist Gynecologic Clinic
- Charlottenlund
- Denmark
- Svend Lindenberg md, drsci
- Professor of Reproduction Fertility Clinic
- Copenhagen
- Denmark
- Anna Veiga Lluch phd
- Scientific Director
- Service of Reproductive Medicine
- Department of Reproductive Medicine
- Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Stem Cell Bank Director
- Center of Regenerative Medicine in Barcelona
- Biomedical Research Park
- Barcelona
- Spain
- Ragaa Mansour md, phd
- Director
- The Egyptian IVF-ET Center
- Cairo
- Egypt
- Francisca Martínez md
- Gynecologist Service of Reproductive Medicine
- Department of Reproductive Medicine
- Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Barcelona
- Spain
- Roberto Matorras md
- Professor and Chairman
- Head of the Human Reproduction Unit, Department of Obstetrics and Gynecology
- Hospital de Cruces, IVI Bilbao Basque Country University
- Bilbao
- Spain
- Rosario Mendoza md
- Embryologist
- Human Reproduction Unit
- Department of Obstetrics and Gynecology, Hospital de Cruces Basque Country University
- Bilbao
- Spain
- Yashodhara Mhatre md
- Consultant
- Center For Human Reproduction
- Dr LH Hiranandani Hospital
- Hiranandani Gardens
- Powai
- Mumbai
- Hans Wilhem Michelmann md, dsc, dr sc agr
- Professor and Head
- Reproductive Medicine Study Group Laboratories
- Department Obstetrics and Gynecology
- University of Goettingen
- Goettingen
- Germany
- Meheranghiz B Minbattiwalla phd
- Senior Clinical Embryologist Pedieos IVF Center
- Nicosia
- Cyprus
- Markus Montag phd
- Reproductive Biologist
- Department of Endocrinology and Reproductive Medicine
- University of Bonn, Bonn
- Germany
- Arturo Garza Morales md
- Director
- Vida Clinic, Matamoros
- Mexico, Hospital de Especialidades Puerta de, Hierro Guadalajara, México
- Ashwini Nagvekar msc
- Embryologist
- Rotunda - The Center For Human Reproduction, Bandra, Mumbai
- India
- João Batista Alcântara Oliveira md, phd
- Gynecologist
- Center for Human Reproduction Prof. Franco Junior Alto da Boa Vista
- Brazil
- Nuria Parera md
- Gynecologist
- Service of Reproductive Medicine
- Department of Reproductive Medicine, Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Barcelona, Spain
- Efraín Pérez-Peña md
- Director
- Vida Institute of Human Reproductive Sciences
- Hospital de Especialidades Puerta de Hierro
- Guadalajara
- México
- Sandro Savino Petrilli md, phd
- Laboratory Director
- Siena Fertility Center
- Monteriggioni (Siena Nord)
- Italy
- Botros Rizk md, ma, facog, facs, hcld, frcog, frcs (c)
- Professor and Head
- Division of Reproductive Endocrinology and Infertility
- Department of Obstetrics and Gynecology, University of South Alabama, Alabama
- USA
- Dalia Rodríguez md
- Gynecologist Service of Reproductive Medicine
- Department of Reproductive Medicine, Obstetrics and Gynecology (RMO and G)Instituto Universitario Dexeus
- Barcelona, Spain
- Francisco Rojas md
- Instituto Vida
- Hospital de Especialidades Puerta de Hierro, Guadalajara
- México
- Kåre Rygaard md, dmsc
- Consultant
- Trianglen Fertility Clinic
- Hellerup
- Denmark
- Hassan N Sallam md, frcogphd (london)
- Professor in Obstetrics and Gynecology, University of Alexandria, and Director of the Suzanne Mubarak Regional Center for Women's Health and Development, Alexandria
- Egypt
- Eyal Schiff md
- Professor and Head
- Department of Obstetrics and Gynecology
- Chaim Sheba Medical Center
- Tel Hashomer
- Sackler Faculty of Medicine
- Tel Aviv University
- Israel
- Daniel S Seidman md
- Director, R and D Unit
- Professor
- Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer
- Sackler Faculty of Medicine Tel Aviv University
- Israel
- Peter Sjoblom phd
- Scientific Director
- Fertility Center Scandinavia
- Stockholm
- Sweden
- Kelton Paul Tremellen mbbs (hons) phd, franzcog, crei
- Director
- Repromed, The Reproductive Medicine Unit of the University of Adelaide, Dulwich South Australia
- Research Center for Reproductive Health, Department of Obstetrics and Gynecology
- The University of Adelaide
- Adelaide
- Australia
- Krinos M Trokoudes md
- Endocrinologist and Infertility Specialist
- Pedieos IVF Center
- Nicosia
- Cyprus
- Rosa Tur md
- Service of Reproductive Medicine
- Department of Reproductive Medicine
- Obstetrics and Gynecology (RMO and G) Instituto Universitario Dexeus
- Barcelona
- Spain
- Hans van der Ven md
- Gynecologist
- Department of Endocrinology and Reproductive Medicine
- University of Bonn
- Bonn
- Germany
- Katrin van der Ven md
- Gynecologist
- Department of Endocrinology and Reproductive Medicine
- University of Bonn, Bonn
- Germany
- Attila Vereczkey md, ma
- Specialist in Obstetrics and Gynecology
- Director of Nyiro Gyula Hospital
- Department of Infertility and Assisted Reproductive Techniques Reproductive Endoscopic Surgery
- Budapest
- Hungary
- Elisabet Stener-Victorin rpt, phd
- Associate professor
- Researcher
- Institute of Neuroscience and Physiology
- Department of Physiology/Endocrinology
- Sahlgrenska Academy
- Göteborg University
- Göteborg
- Sweden
- Danielle Vicus md
- Department of Obstetrics and Gynecology
- The Chaim Sheba Medical CenterTel-Hashomer and Sackler Faculty of Medicine
- Tel-Aviv University
- Tel-Aviv
- Israel
- Lars Grabow Westergaard md, dmsc
- Professor, Human Reproductive Medicine
- University of Southern Denmark
- Fertility Clinic
- Department of Obstetrics and Gynecology
- Odense University Hospital
- Denmark
- Matts Wikland md, phd
- CEO
- Fertility Center
- Gothenburg
- Sweden
- Amir Wiser md
- Senior physician
- IVF Unit
- Department of Obstetrics and Gynecology
- Chaim Sheba Medical Center
- Tel Hashomer
- Sackler Faculty of Medicine
- Tel Aviv University
- Israel
- Mei Yin ms
- West Coast IVF Clinic, Inc.
- Los Angeles Center for Embryo Implantation (SEED)
- Los Angeles, California
- USA
- Josef Zech mdceo
- Private Kinderwunsch-Clinic Grabenweg
- Innsbruck
- Austria