Drugs in Pregnancy—How Safe? Dilip Kumar Dutta
INDEX
ABCDEFGKLMOPRSTUX
A
Alcohol in pregnancy 43
alcohol used during pregnancy 43
clinical characteristics 43
diagnostic approach 44
differential diagnosis 44
etiology and pathogenesis 43
management and therapy 44
nonpharmacological 44
Antibiotics in pregnancy 42
antibiotics to be avoided 42
prophylactic antibiotics 42
Ayurvedic drugs during pregnancy 56
Maharishi vedic medicine to the
postpartum mother 58
treatments protocol 58
other accessory techniques applied to the mother and unborn child 56
pregnant woman's diet 56
techniques recommended for bringing balance in pregnancy 57
B
Blastomeres 3
Breastfeeding 55
C
Causes of renal failure 59
clinical presentation 60
differential diagnosis 61
investigations in acute renal failure 61
biochemistry 61
hematology 61
imaging 61
microbiology 61
management 62
medical management 62
phase of diuresis 63
re-established acute renal failure 62
reversible prerenal acute renal failure 62
obstetrical management 64
early pregnancy 64
late pregnancy and labor 64
mid pregnancy 64
pathogenesis 59
established acute renal failure 60
reversible prerenal acute renal failure 59
prognosis 64
Characteristics of teratogenic effect 13
genetic difference 13
gestational age 14
mode of action 14
species difference 13
specificity 13
Chromosomal disorder 20
Common drugs used in pregnancy and their effects on the baby 36
anticoagulants 37
heparin 38
anticonvulsants 37
diazepam 37
magnesium sulphate 37
phenytoin 37
diuretics 37
hazards 37
drug used in labor 39
ergot derivatives 39
misoprostol 40
oxytocin 39
prostaglandins 40
drugs used during antenatal period 36
angiotensin converting enzyme (ACE) inhibitors 37
calcium channel blockers 37
sympatholytics 36
vasodilators 36
tocolytic agents 38
betamimetics 38
calcium channel blockers 38
indomethacin 38
magnesium sulphate 38
nitric oxide (No) donors 39
oxytocin antagonists 39
Conceptional period 21
Constipation in pregnancy 53
Cystic fibrosis 19
D
Development of baby in utero 3
Down syndrome 23
Drug addiction during pregnancy 46
caffeine 46
cocaine and methamphetamine 47
heroin and other narcotics 47
inhalants 47
marijuana 47
medications 48
PCP 47
Drugs and the stages of pregnancy 1
Drugs used during breastfeeding 66
types of drugs prescribed 66
cytotoxic drug 66
drug of abuse 66
psychotropic drugs 66
radioactive compounds 67
Drugs used for medical disorders in pregnancy 26
analgesics 29
anesthetics 30
anticoagulants 29
anticonvulsants 30
antiemetics 28
antimicrobial drugs 28
antithyroid drugs 30
cardiotonic drugs 28
corticosteroids 28
hypoglycemic drugs 27
hypotensive drugs 27
immunosuppressives 31
sedatives and tranquillizers 27
vaccination and immunization 31
Drugs used in pregnancy and its effects on baby and infants 71
E
Effects of smoking after pregnancy 51
body and lungs 51
brain function 51
weight and size 51
Effects of smoking during pregnancy 50
carbon monoxide and nicotine 50
other dangerous effects of smoking during pregnancy 51
premature babies 50
F
Fallopian tube 3
Fertilization 3
Fetal hazards 40
Fluorescent in situ hybridization 23
G
General anesthetic drugs 33
Genetic disorders and birth defects 17
dominant disorders 18
gene and genetic defects 17
genes and chromosomes 17
genetic counselling 17
genetic disorders 18
incidence and prevalence 17
risk factors 18
Genetic test 22
K
Klinefelter's syndrome 23
L
Local anesthetic drugs 32
M
Major teratogenic effects on pregnancy 15
cytotoxic drugs 15
radioactive isotopes 16
tetracycline 15
Material serum markers 22
Metabolism in the uterus 12
Multifactorial disorders 20
O
Ovulation stimulants 24
P
Peri-conceptional period 21
Placental transfer of drugs 12
Post-conceptional period 22
Pre-implantation genetic disorders 23
Prevention of genetic disorders 25
primary prevention 25
secondary prevention 25
R
Recessive disorders 18
Role of progesterone and hCG treatment in early pregnancy 68
efficacy and safety of hCG 69
efficacy and safety of progestogens 69
hCG levels in week from LMP 68
progesterone levels during pregnancy 69
S
Screening test for thalassemia 24
Sedatives 35
Sex hormones 24
Stage of birth 2
Stage of organ formation 1
Stage of prenatal growth 1
Symptoms of pregnancy and its management 52
Systemic analgesics 34
T
Tay-Sachs disease 19
Thalassemia 19
Torch test 23
Turner's syndrome 23
U
Uterine cavity 3
X
X-linked disorder 20
×
Chapter Notes

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1Drugs in Pregnancy— How Safe?
2

DISCLAIMER

Every effort has been made to ensure that the drug doses herein are accurate and in accordance with the standards accepted at the time of publication. However, the user is advised to check the doses carefully. The author/publisher shall not be responsible for any error in this publication. Besides, as new research and experience broaden our knowledge, changes in treatment and drug therapy occur. Therefore, the reader is advised to check the product information sheet included in the package of every drug he or she plans to administer to be certain that changes have not been made in the recommended dosage or in the contraindications. This is of particular importance in regard to new or infrequently used drugs.
3Drugs in Pregnancy— How Safe?
Dilip Kumar Dutta MD, MAMS, FICOG, FICMCH, MAFS (USA) Dip. Pelviscopic Surgery (Germany) Director of Global Institute of Gynaecology, Kalyani, WB India
4Published by
Jitendar P Vij
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Drugs in Pregnancy—How Safe?
© 2008, Jaypee Brothers Medical Publishers
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First Edition: 2008
9788184483253
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Printed at Gopsons
5Preface
For a pregnant woman, drug abuse is doubly dangerous. Firstly, drugs may harm her own health, interfering with her ability to support the pregnancy. Secondly, some drugs can directly impair prenatal development. Some drugs can be harmful when used at any time during pregnancy; others, however, are particularly damaging at specific stages.
Till date no comprehensive book regarding drugs used during pregnancy has been published. It is our duty to analyse potential risks along with potential benefits of drugs used during pregnancy and its effects on the baby.
This book is not only highlighted-development of baby in utero, teratogenesis and other adverse effects of drugs during pregnancy, major teratogenic effects on pregnancy, common drugs used in pregnancy and its effects on neonates, but also focussed alcohol, drug addiction, smoking during pregnancy and their effects on baby, and lastly role of progesterone and hCG treatment in early pregnancy and their safety.
I am very much thankful to Jaypee Brothers Medical Publishers to publish this book. Lastly this book will definitely help the practicing obstetrician in day-to-day practice.
Dilip Kumar Dutta678