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Comprehensive Cardiology
S Uma Devi
CHAPTER 1:
Acute Rheumatic Fever
DEFINITION
ETIOLOGY
PATHOGENESIS
HISTOLOGY AND PATHOLOGY
DIAGNOSIS
JONE'S CRITERIA
CLINICAL FEATURES
Incidence
Epidemiology
Rheumatic Polyarthritis
Acute Rheumatic Carditis
Frequency of Valvular Involvement
Rheumatic chorea or Sydenham's chorea (Chorea minor, St. Vitus dance)
Types of Chorea
Skin Rashes in Rheumatic Fever
Erythema Marginatum
Erythema Nodosum
Minor Manifestations of Rheumatic Fever
The Natural Course of the Disease
Differential Diagnosis
INVESTIGATIONS
Evidence of Systemic Illness
Evidence of Preceding Streptococcal Infection
Evidence of Carditis
MANAGEMENT
Bed Rest
Drug Therapy
Indications for Steroids
STEROIDS
PREVENTION OF RHEUMATIC HEART DISEASE
Primary Prevention (During the Course of Acute Rheumatic Fever)
Secondary Prevention
CHAPTER 2:
Mitral Stenosis
DEFINITION
ETIOLOGY
Pathology
HEMODYNAMICS OF MITRAL STENOSIS (FIG. 2.2)
CLINICAL PICTURE
Symptoms
Signs
Diagnostic Features
Differential Diagnosis for Clinical Picture of Mitral Stenosis
Differential Diagnosis—For Mid Diastolic Murmur
Other Conditions Causing Loud I Sound
Other Conditions Causing Opening Snap
Assessments in Mitral Stenosis
Complications of mitral stenosis
Complications of Pulmonary Venous Congestion
Complications of Enlarged Left Atrium
Complications at Valve Level
INVESTIGATIONS
X-ray Chest
Barium Swallow
ECG
ECHO
Doppler
TEE
Catheterization
TREATMENT
INTERVENTION
Mitral Balloon Valvuloplasty
Technique of Balloon Valvuloplasty
Complications of Balloon Valvuloplasty
Surgery for Mitral Stenosis
Mitral Valvotomy
Closed Valvotomy
Open Valvotomy
MITRAL VALVE REPLACEMENT
Indications
Types of Prosthetic Valves (Fig. 2.4)
Mechanical
Complications
Complications of Valve Replacement
SUMMARY
Management of Mitral Stenosis
CHAPTER 3:
Mitral Regurgitation
DEFINITION
ETIOLOGY
HEMODYNAMICS OF ACUTE MR (FIG. 3.1)
HEMODYNAMICS OF CHRONIC MR (FIG. 3.1)
CLINICAL PICTURE IN MITRAL REGURGITATION
Symptoms
Signs
Murmur (Fig. 3.2)
Quality of the Murmur
DIAGNOSIS
DIFFERENTIAL DIAGNOSIS
Features of Dominant MR in Mixed Lesion (MS and MR)
Conditions where severe MR can be silent
Clues to the presence of MR in silent MR
Clinical features in Severe MR
Complications
INVESTIGATIONS
CXR
ECG
Echocardiography (findings depend upon the cause)
Echo Assessment
Radionuclide Studies
Catheterization and Angiography
LV Angiography
TREATMENT
Medical
Preventive Measures in MR
Surgical
SERIAL ASSESSMENT
Assessment of LV Function
Ejection Fraction
End Systolic Dimension
Contraindications for Surgery
SUMMARY
Acute MR
Prognosis
Poor Prognosis
CHAPTER 4:
Mitral Valve Prolapse Syndrome
SYNONYMS
INCIDENCE
ETIOLOGY
PATHOPHYSIOLOGY (FIG. 4.1)
CLINICAL PICTURE
Symptoms
Signs
MURMUR (FIG. 4.2)
INVESTIGATIONS
CXR
ECG
Course
TREATMENT
CHAPTER 5:
Aortic Stenosis
DEFINITION
Etiology
Congenital
Rheumatic AS
Atherosclerotic
Calcific AS
PATHOLOGY
HEMODYNAMICS IN AS (FIGS 5.1A AND B)
CLINICAL PICTURE OF AORTIC STENOSIS
DIAGNOSIS
DIFFERENTIAL DIAGNOSIS
INVESTIGATIONS
1. ECG
2. X-ray Chest
3. Cardiac Catheterization
4. Angiography
5. Echo and Doppler
6. EBCT
7. Stress Test
Complications of Aortic Stenosis
TREATMENT
Medical
Surgery
Indications for Surgery
Procedures
Valve Replacement (Autograft/Xenograft/Mechanical)
Aortic Balloon Valvuloplasty
Assessment of Severity of Aortic Stenosis: For surgery
Recent Advances in Surgery: Ross Procedure for AS
SUPRAVALVULAR AORTIC STENOSIS (FIG. 5.3)
Associated Features
Clinical Features
SUBVALVULAR AORTIC STENOSIS (FIG. 5.4)
Hypertrophic Obstructive Cardiomyopathy
Clinical Features of HOCM
Types of Subvalvular Aortic Stenosis
CHAPTER 6:
Aortic Regurgitation
DEFINITION
ETIOPATHOLOGY
ETIOLOGY
Acute Causes
Chronic
Congenital
Infective
Arthritic disease
Inherited disorder of connective tissues
Degenerative conditions
Miscellaneous
HEMODYNAMICS (FIG. 6.1)
CLINICAL FEATURES
PULSE
Heart Sounds
Variation in A2
Murmurs (Fig. 6.2)
Other Associated Murmurs
PERIPHERAL SIGNS OF AORTIC REGURGITATION
Mixed Aortic Lesion
INVESTIGATIONS
X-ray Chest
ECG
Echocardiogram
Echo Dimensions and Follow Up
Radionuclear Ventriculogram
MRI and Ultra Fast CT Scan
TREATMENT
Medical
SURGICAL MANAGEMENT
Acute Aortic Regurgitation
Surgical techniques
Chronic Aortic Regurgitation
CHAPTER 7:
Tricuspid Stenosis
ETIOLOGY
PATHOLOGY
HEMODYNAMICS
CLINICAL PICTURE
Symptoms
Signs
On Auscultation
COMPLICATIONS
INVESTIGATIONS
1. ECG
2. CXR
3. Echo
4. Doppler
5. Cardiac Catheterization
TREATMENT
Medical
Surgical
CHAPTER 8:
Tricuspid Regurgitation
ETIOLOGY
Functional
Organic
HEMODYNAMICS
CLINICAL PICTURE
Symptoms
Signs
INVESTIGATIONS
CXR
ECG
Echo and Doppler
Cardiac Catheterization and Angiography
TREATMENT
Medical
Surgery
CHAPTER 9:
Infective Endocarditis
ENDOCARDITIS
Microbiological Features
Causative Organism
Bacteriae
Infection is usually by a gram-positive coccus
Other causes of acute endocarditis
Postoperative endocarditis
Gram-negative bacteria (HACEK Group)
Q fever endocarditis
Brucella
Fungi
Usual source of invading organisms
Lesions Liable for Infective Endocarditis
PATHOLOGY
CLINICAL FEATURES
CLINICAL COURSE
Acute
Subacute
Postoperative endocarditis
Right-sided endocarditis
Prosthetic valve endocarditis
Complications of Infective Endocarditis
INVESTIGATIONS
ROLE OF ECHOCARDIOGRAPHY IN DIAGNOSING IE
TREATMENT
REASON
Appropriate Antibiotic
Audiometry
Dose
Timing of valve replacement in IE
Glideline indications for cardiac surgery
PROPHYLAXIS
NON-INFECTIVE ENDOCARDITIS
CHAPTER 10:
Introduction to Congenital Heart Diseases
CLASSIFICATION OF CONGENITAL HEART DISEASES
USUAL AGE OF APPEARANCE OF SIGNS
SYMPTOMS OF CONGENITAL HEART DISEASES
APPROACH TO A CASE OF SUSPECTED CONGENITAL HEART DISEASE
History to be Elicited
Present history
Maternal history
History of child
Family history
SCREENING FOR SUSPECTED CONGENITAL HEART DISEASE IN FETUS
ABNORMALITIES DETECTED AT BIRTH AND SOON AFTER
HEMODYNAMIC CLASSIFICATION OF CONGENITAL HEART DISEASES
GENERAL EXAMINATION
Differential Cyanosis
PULSE
BP
JVP
EXAMINATION OF PRECARDIUM
Pulsations
Apical impulse
Enlarged heart
PALPATION
AUSCULTATION
EJECTION CLICK
MURMUR
CHAPTER 11:
Atrial Septal Defect
DEFINITION
TYPES OF ATRIAL SEPTAL DEFECTS (FIG. 11.1)
EMBRYOLOGY (FIG. 11.2)
HEMODYNAMICS (FIG. 11.3)
General Examination
Marfan's syndrome
Holt-Oram syndrome
Trisomy-13—Patau's syndrome
Trisomy-18: Edward's syndrome
Mongolism
Lutembacher's syndrome
Cyanosis in ASD
Examination of CVS
The arterial pulse
JVP
The precardium
Palpation
Auscultation
Fixed splitting of II sound –
Fixed Splitting
Intensity of P2 in ASD
Murmurs in ASD
Features of ASD with pulmonary hypertension
DIAGNOSIS OF ASD
Treatment
Medical
SURGICAL
CHAPTER 12:
Anomalous Pulmonary Venous Connection
TYPES
SITE OF CONNECTION
CLASSIFICATION ACCORDING TO SITE OF JUNCTION OF COMMON PULMONARY VEIN WITH THE HEART (FIG. 12.3)
HEMODYNAMICS
TYPES OF CLINICAL PRESENTATION OF TAPVC
CLINICAL PICTURE OF TAPVC
Investigations
Cardiac catheterization
Angiography
Echo
PARTIAL ANOMALOUS VENOUS CONNECTION
CHAPTER 13:
Ventricular Septal Defect
TYPES OF VSD (FIG. 13.2)
Hemodynamics (Fig. 13.3)
Hemodynamics in summary
Course of circulation
Pulmonary over load and pulmonary vascular pattern
Pulmonary Hypertension
Eisenmenger's Syndrome
Hemodynamic Classification of VSD
Signs
General examination
Cardiovascular Examination
AUSCULTATION
NATURAL COURSE
INVESTIGATIONS
ECHO
COMPLICATIONS OF VSD
TREATMENT
CONTRAINDICATIONS FOR SURGERY
RECENT ADVANCES IN SURGICAL PROCEDURES
CHAPTER 14:
Persistent Ductus Arteriosus
DEFINITION
DEVELOPMENT
Hemodynamics (Fig. 14.2)
Shunt pathway
FETAL CIRCULATION
HISTORY TO BE ELICITED
Clinical Features
General Examination
Symptoms
CVS –Signs
Auscultation
Murmur of the defect (Fig. 14.3)
Flow murmurs in PDA
Reversal – Clinical picture;
CVS
II heart sound in PDA
Diagnostic Features of PDA
Investigations
Associated anomalies
Complications
Condition where PDA is essential for survival
Treatment
Medical
Surgical: Standard Approach
Devices used for occlusion of PDA through catheterization (Percutaneous trans catheter occlusion)
Conditions causing continuous murmur
Extracardiac conditions
Intracardiac conditions
Arterial stenosis
Increased flow through normal vessels
Differential diagnosis of continuous murmur.
CHAPTER 15:
Coarctation of Aorta
DEFINITION
Histologically
Embryologically
TYPES OF COARCTATION
HEMODYNAMICS
CLINICAL PICTURE
Symptoms
General examination
CARDIOVASCULAR SYSTEM
Palpation
AUSCULTATION
Heart Sounds
Ejection Click
Murmurs
Coarctation murmur
Bicuspid Aortic Murmur
Diastolic Murmurs
DIAGNOSTIC CRITERIA
DIFFERENTIAL DIAGNOSIS
ASSOCIATED ANOMALIES FEATURES
NATURAL HISTORY
INVESTIGATIONS
X-ray Chest
Dock's sign
Other Conditions Causing Rib Notching
Electrocardiography
Echocardiography
COLLATERALS IN COARCTATION
I. Internal Mammary—Inferior Epigastric Route
II. Periscapular—Intercostals Route
TREATMENT
Surgical Procedure
Primary ballooning and/or stenting.
After Surgery
Intraoperative Complication
Postoperative Complications
Follow up
CHAPTER 16:
Tetralogy of Fallot
INTRODUCTION
Developmental Defect
HEMODYNAMICS
Severe Pulmonary Stenosis
Large VSD
Shunt: Right to Left Shunt
Low Pulmonary Artery Pressure
CLINICAL PICTURE
Symptoms
Features of Anoxic Spells
REASON FOR ABSENCE OF CYANOSIS AT BIRTH IN FALLOT
SIGNS OF TETRALOGY
ASSOCIATED ANOMALIES
DIAGNOSTIC FEATURES
DIFFERENTIAL DIAGNOSIS (TABLE 16.1)
Conditions with Ischemic Lung Fields
Conditions with Plethoric Lung Fields
INVESTIGATIONS
X-ray Chest
ECG
ECHO
COMPLICATIONS
Cardiac Failure in Fallot
TREATMENT
Medical
Assessment of Severity of PS
Severity of TOF
SURGICAL (FIGS 16.3A TO D)
Indications
Complications of Surgery
Variants of Fallot
CHAPTER 17:
Ebstein's Anomaly
ANATOMY OF EBSTEIN'S ANOMALY (FIG. 17.1)
HEMODYNAMICS
CLINICAL PRESENTATION
AUSCULTATION (FIG. 17.2)
Prognosis
Treatment
CHAPTER 18:
Complete Transposition of the Great Arteries
SIMPLE (DEXTRO) TRANSPOSITION (FIG. 18.1)
Embryological Abnormality
HEMODYNAMICS
CLINICAL PICTURE
AUSCULTATION
Associated Anomalies
INVESTIGATIONS
ECG
X-ray Chest
Echocardiography (Diagnostic)
CARDIAC CATHETERISATION
TREATMENT
CONGENITALLY CORRECTED (LAEVO) TRANSPOSITION OF THE GREAT VESSELS (FIG. 18.2)
Embryological Abnormality
HEMODYNAMICS
CLINICAL PRESENTATION
ASSOCIATED ANOMALIES
INVESTIGATIONS
ECG
Chest X-ray
ECHO
TREATMENT
CHAPTER 19:
Tricuspid Atresia
ANATOMY
HEMODYNAMICS
TYPES
SUB TYPES
CLINICAL PICTURE
INVESTIGATIONS
PROGNOSIS
Surgical Treatment
CHAPTER 20:
Pulmonary Stenosis—Valvular with Intact Ventricular Septum
BACKGROUND
ETIOLOGY
INCIDENCE
Supravalvular [Synonym: Peripheral pulmonary stenosis (PPS)]
VALVULAR PULMONARY STENOSIS (FIG. 20.1)
CLINICAL FEATURES
General
CARDIOVASCULAR SYSTEM
CRITERIA FOR MAKING THE DIAGNOSIS OF VALVULAR PULMONARY STENOSIS
DIFFERENTIAL DIAGNOSIS
INVESTIGATIONS
ECG Features
X-ray Chest
Cardiac Catheterization
Angiocardiography
Echo
COMPLICATIONS
PROGNOSIS
Medical Treatment
INDICATIONS FOR SURGERY
Types of Surgery
ASSOCIATED ANOMALIES
Key Points about Pulmonary Stenosis
CHAPTER 21:
Cardiac Malposition and Dextrocardia
CARDIAC MALPOSITION
CARDIAC DISPLACEMENT
SITUS
Segmental Approach
DEXTROCARDIA
Definition
Development
Clinical Examination in Dextrocardia
Investigations
TYPES OF DEXTROCARDIA
True Dextrocardia
Isolated Dextrocardia without Situs
True Dextrocardia as Part of Situs Inversus
Syndrome associated;
LEVOCARDIA (FIG. 21.4)
MESOCARDIA
ECTOPIA CORDIS
Situs (Abdominal)
Types
Types of Situs Inversus.
Boundaries
Surface anatomy of Traube's space;
Dextroversion versus Dextroposition
Levoversion (levocardia)
CHAPTER 22:
Idiopathic Dilatation of Pulmonary Artery
ANATOMY
CLINICAL FINDINGS
AUSCULTATORY FEATURES
INVESTIGATIONS
CHAPTER 23:
Anomalous Origin of Coronary Arteries (Isolated)
ANOMALOUS ORIGIN OF LEFT CORONARY ARTERY FROM PULMONARY ARTERY
TREATMENT
Surgical Correction
ORIGIN OF LEFT MAIN CORONARY ARTERY FROM RIGHT SINUS OF VALSALVA
Anatomy of the Defect
Clinically
Treatment
Right Coronary Arising Aberrantly from Left Sinus of Valsalva
CHAPTER 24:
Congenital Complete Heart Block
ETIOLOGY
ASSOCIATED CARDIAC ANOMALIES
COMPLICATIONS
Factors Identifying High Risk Patients
Treatment
CHAPTER 25:
Hyperlipidemias
CLINICAL IMPORTANCE OF LIPOPROTEINS
Important Lipids in the Blood
PHYSIOLOGICAL FUNCTIONS OF LIPIDS
CLASSIFICATION OF LIPOPROTEINS BASED ON ULTRACENTRIFUGATION/ELECTROPHORESIS (FIG. 25.1)
APOPROTEINS
Importance of Lp (a)
Lipid transport in the blood
DYSLIPIDEMIA/HYPERLIPIDEMIA
Types
Primary
Secondary
Diets
Drugs
TREATMENT OF HYPERLIPIDEMIA
Stage I
Stage II
Drug therapy
Side effects:
Regression of coronary lesions on treatment
RECENT ADVANCES
CHAPTER 26:
Systemic Arterial Hypertension
DEFINITION, DETECTION, EVALUATION AND CLINICAL PICTURE OF HYPERTENSION
EVALUATION
TYPES AND NOMENCLATURES IN HYPERTENSION
BP Measurement Devices
Hypertensive Crisis (Refer page no. 210 also)
Hypertensive Urgency
Level of Hypertension and Vascular Damage
PATHOLOGY OF HYPERTENSION
Hemodynamics
Heart
Vascular changes
Neurohormonal
CLINICAL MANIFESTATIONS OF HYPERTENSION
SECONDARY HYPERTENSION
Diseases Causing Secondary Hypertension
Secondary hypertension: Curable
Signs of secondary hypertension
COMPLICATIONS OF HYPERTENSION
Malignant Hypertension
Pathogenesis
INVESTIGATIONS
TREATMENT OF SYSTEMIC ARTERIAL HYPERTENSION
Antihypertensive Drug Therapy
Principles
In Practice
Alternative antihypertensives
Antihypertensives and their Compelling Indications
Management of Patients with Concomitant Diseases (Table 26.6)
PARENTERAL TREATMENT: IN MALIGNANT HYPERTENSION–REDUCING BP OVER MINUTES TO HOURS (TABLE 26.5)
Indication
Sodium Nitroprusside
Disadvantage
NITROGLYCERINE
LABETALOL
PHARMACOTHERAPEUTICS OF ANTIHYPERTENSIVES (FIG. 26.1)
I. FIRST-LINE ANTIHYPERTENSIVE DRUGS
Thiazide Diuretics
Action
Place in therapy;
Loop Diuretics
Beta Adrenergic Blockers (Table 26.7)
Calcium Channel Blockers (Table 26.8)
Dihydropyrimidine derivatives
ACE Inhibitors (ACEI)
Drugs
II. ALTERNATIVE ANTIHYPERTENSIVE DRUGS
Introduction
Enumeration
A. Angiotensin II Receptor Antagonists
B. Alpha Blockers (Selective alpha 1 adrenoreceptor antagonists)
C. Centrally Acting Drugs
Drugs
Direct Acting Vasodilators
Troubles and Difficulties of IV Nitrates
Adjuvant Drug Therapy in Hypertension
Points to note in drug therapy
CHAPTER 27:
Coronary Heart Diseases
STABLE ANGINA (FIG. 27.1)
Causes
Pathogenesis
Clinical Features of Angina Pectoris
Breathlessness sometimes is a prominent feature of angina.
Differential Diagnosis
Investigations: Non-invasive
Other Forms of Stress Testing
Other non-invasive Investigations
INVASIVE INVESTIGATION
Indication
RISK STRATIFICATION IN ANGINA
MANAGEMENT OF STABLE ANGINA
TREATMENT OF STABLE ANGINA
MEDICAL THERAPY OF ANGINA
ANGINA WITH NORMAL CORONARY ARTERIES
CORONARY ARTERY SPASM (PRINZMETAL'S ANGINA)
Cardiac Syndrome X
UNSTABLE ANGINA
Definition
Pathophysiology (Fig. 27.3)
ACUTE CORONARY SYNDROME
Diagnosis and Investigations
ECG
Difference in treatment of three types of angina.
Summary of treatment of acute coronary syndrome: Two approaches available
Risk stratification in ACS
STEP I
Pharmacological Management–Unstable Angina/ACS
Aggressive Pharmacological Therapy is a Must
A. Antiplatelet Treatment in Unstable Angina
B. Anticoagulation
C. Anti-ischemic Therapy
Morphine
β−blocker
ACE Inhibitor in HT /CHF /Diabetes
Calcium Channel Blockers
Intra-aortic balloon pump counter pulsations;
STEP II
REVASCULARIZATION URGENTLY DONE IN HIGH RISKS
UNSTABLE ANGINA AND REVASCULARIZATION
Definition
Unstable angina and Non ST elevation MI
PATHOPHYSIOLOGY OF MYOCARDIAL INFARCTION
Risk Factors
CLINICAL PICTURE IN MI
Symptoms
Timing of Infarction
Signs
Differential Diagnosis
INVESTIGATIONS
PLASMA BIOCHEMICAL MARKERS
IMAGING TESTS
Myocardial Perfusion Imaging
MANAGEMENT OF MYOCARDIAL INFARCTION (FLOW CHART 27.1)
EARLY MANAGEMENT OF MYOCARDIAL INFARCT (FLOW CHART 27.1)
DRUG THERAPY
SUBSEQUENT MANAGEMENT
COMPLICATIONS (FLOW CHART 27.3)
Arrhythmias
Sinus bradycardia
Heart block
Acute Cardiogenic Shock
Pulmonary Edema
Pericarditis
Embolism
Mechanical Complications in MI Papillary Muscle Damage
Rupture of Interventricular Septum (Fig. 27.6)
Rupture of ventricles and cardiac tamponade.
Impaired Ventricular Function, Remodeling and Ventricular Aneurysm
Ventricular aneurysm
LATE MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION
Risk Stratification
Left Ventricular Function
Ischemia
Arrhythmias as Late Complication
Drug treatment
Statin
LIFESTYLE MODIFICATION
MOBILIZATION AND REHABILITATION AFTER MI
Post MI-outpatient Assessment
Prognosis of Acute MI
RIGHT VENTRICULAR INFARCT
Diagnosis
Progress
Hemodynamics
Pathognomic clinical triad
Complications
Differential Diagnosis
Treatment
TYPES
ACUTE “PHARMACOLOGICAL REPERFUSION” OF CORONARY THROMBUS
Thrombolysis
Benefits
Indications for Thrombolysis
ECG Criteria
Absolute
Complications of thrombolytic therapy
“Choice of thrombolytic drug is less important than speed of treatment.”
Bolus Derivatives
DOSE OF FIBRINOLYTICS (THROMBOLYTICS)
Streptokinase
MAIN ADVANTAGE OF FIBRINOLYTIC THERAPY
MECHANICAL REPERFUSION
Percutaneous Coronary Intervention (PCI)
Indications for PCI
Stent
Drug Eluting Stent
PRIMARY ANGIOPLASTY
Definition
Advantages over thrombolytics
Disadvantages of primary PTCA/PCI
RESCUE ANGIOPLASTY
Definition
Indication for rescue angioplasty;
Disadvantage
SURGICAL REPERFUSION CORONARY ARTERY BYPASS SURGERY (CABG)
Indications
Recurrence of angina after CABG
Nitrovasodilators
DURATION OF ACTION
BETA-BLOCKERS
CALCIUM CHANNEL BLOCKERS
Classification of Calcium Channel Blockers (CCB)
K+ CHANNEL ACTIVATORS (OPENER)
Action
ANTIPLATELET AGENTS (PROPHYLACTIC)
GLYCOPROTEIN IIB/IIIA INHIBITORS (SEE FIG. 27.4)
Indications
Other laser procedure
Enhanced external counter pulsation (EECP)
Beating Heart Surgery
Arterial Type Coronary Artery Bypass Surgery (See Fig. 27.9)
Newer developments in preventing restenosis
ADJUVANT MEDICAL THERAPY IN PCI
Recommendations
I. Preventive
II. Therapeutic
Adjunctive antithrombotic therapy for ST elevation acute MI
Adjunctive antithrombotic therapy
PHARMACOTHERAPEUTICS OF ADJUVANT DRUGS (FIGS 27A.1 AND A.2)
I. Antithrombotic Agents
II. Antiplatlet Agents
III. Thrombolytic Agents
Indirect Antithrombins
Low molecular weight heparin
REPERFUSION INJURY
CHAPTER 28:
Heart Failure
FORMS, PATHOPHYSIOLOGY AND CLINICAL FEATURES OF HEART FAILURE
Definition
I. Cardiac Diseases
Structural Abnormalities
II. Non-cardiac Diseases
III. Precipitating Causes
FORMS OF CARDIAC FAILURE
Acute/Chronic Failure
Acute
Chronic
Biventricular Cardiac Failure
Right-sided Cardiac Failure
Left Sided Cardiac Failure
Systolic/Diastolic Failure
Forward and Backward Failure
Refractory Cardiac Failure
PATHOPHYSIOLOGY OF HF (FLOW CHART 28.1)
Introduction
Details
Effects of Sympathetic Nervous System (SNS) Stimulation
Effects of Renin angiotensin aldosterone system (Flow chart 28.2)
Natriuretic Peptides
Atrial natriuretic peptide (ANP);
Pathophysiology in Diastolic Dysfunction
Changes in structure and biochemical properties
CLINICAL FEATURES OF CARDIAC FAILURE
I. Symptoms
II. Signs of Heart Failure
General examination
A. Right heart failure
B. Left heart failure
C. Acute pulmonary edema
D. Cardiac cachexia;
Framingham Criteria for Diagnosis of Congestive Heart Failure
Investigations
Aim of treatment
Modalities of therapy
Non-drug general measures
Avoid
Administration of O2: Indication guided by pulse oximetry
Other measures
PHARMACOLOGICAL THERAPY IN HF
Summary of Pharmacological Therapy (Flow chart 28.3)
Salient Features About the 4 Groups of Drugs Mainly Used in Treatment of HF (ACEI, β-blockers, diuretics and digoxin) (Table 28.3, Flow charts 28.2 and 28.3)
Risk While Starting ACEI Therapy
Angiotensin Receptor Blockers (ARB)
Beta-blockers (Refer Pharmacotherapeutics section)
Diuretics (Refer also pharmacotherapeutics section)
Aldosterone Antagonists
Digitalis Glycosides (Refer Pharmacotherapeutics)
Benefits
Disadvantages
Endothelin-1 Antagonists
Natriuretic Peptides
Other vasodilators in heart failure therapy
Parenteral vasodilators
ACUTE CARDIOGENIC PULMONARY EDEMA
Newer Modalities of Therapies
Cardiac Resynchronization Therapy (CRT)
Technique
SURGICAL THERAPY FOR CARDIAC FAILURE
Cardiac Transplant (Fig. 28.3)
Indications
Contraindication
Surgical Technique
ARTIFICIAL HEART: LVAD
Diuretics
Loop Diuretics Usage
Action
Angiotensin II Receptor Antagonist
Angiotensin II Receptor Blocker (ARB)
Arteriolar Vasodilators
Nitroprusside—Direct Acting Vasodilators
Side Effects
Cyanide toxicity
Place in therapy of SNP
Drugs to reduce preload
Venodilators
Tolerance
Side effects
Place in therapy—for nitrates
Other vasodilators:
β-blockers
Action
Directly acting arteriolar dilator
Drugs which Augment Myocardial Contraction
Digitalis: Digoxin
Place in therapy
Place in therapy
Route of administration
During Infusion to be monitored are:
Side effect
Place in therapy
But dopamine should never be given via a peripheral line.
Place in therapy
CHAPTER 29:
Cardiac Arrhythmias
INTRODUCTION
Definition
ARRHYTHMIAS DUE TO DISTURBANCE IN IMPULSE FORMATION
Abnormal Automaticity (Fig. 29.1)
Triggered Automaticity (Fig. 29.2)
ARRHYTHMIAS DUE TO DISTURBANCE IN IMPULSE CONDUCTION (BY RE-ENTRY) (FIG. 29.3)
DISTURBANCE IN IMPULSE FORMATION OR IMPULSE CONDUCTION WITHIN SA NODE ITSELF
Sinus Tachycardia
ECG Features
Treatment
Inappropriate Sinus Tachycardia
Treatment
Sinus Node Re-entrant Tachycardia
Treatment
Wandering Atrial Pacemaker
ECG Features
Treatment
Sick Sinus Syndrome
Definition
Classification
Etiology
ECG
Clinically
Treatment
Causes
ECG
Disturbance of Atrial Rhythm
Atrial Premature Beat
Causes
On ECG
Atrial Flutter
Differential diagnosis
Electrophysiological mechanism of atrial flutter (Fig. 29.7)
ECG (Fig. 29.8)
Clinical features
Diagnosis (Fig. 29.9)
Treatment
Atrial Fibrillation (AF)
Mechanism (Fig. 29.10)
ECG (Fig. 29.11)
Causes of atrial fibrillation
Significance of AF
Clinical recognition
Mechanism of pulse deficit
Electrophysiology of atrial fibrillation
AF in elderly
Complications
Differential diagnosis
Investigation
Essential issues of management
Standard treatment: For rate control
Indications for Cardioversion
DC Cardioversion
Contraindication for Cardioversion
Internal Cardioversion
Prevention of AF by drugs
Catheter ablation procedures: (‘Ablate and Pace’)
Prevention by Pace Makers
Anticoagulation in atrial fibrillation
Contraindications (Relative)
Cardioversion and anticoagulation in AF
Classification of Atrial Tachycardia Based on Catheter Ablation Technique
1. Tachycardias that arise from focal areas of atrial tissue.
Radio frequency catheter ablation
2. Re-entrant tachycardia with involving macroscopic anatomical or surgical barriers (Fig. 29.14):
Introduction
According to electrophysiology:
Nomenclatures and Confusions
SUPRAVENTRICULAR TACHYCARDIAS
ATRIAL TACHYCARDIA
Automatic Atrial Tachycardia (Ectopic Atrial Tachycardia)
Multifocal Atrial Tachycardias
Mechanism
Causes
Caution
Atrial Tachycardia Caused By Re-entry
Mechanism
AV Junctional Rhythm Disturbances
AV Nodal Re-entrant Tachycardia (Fig. 29.16)
Synonym: Paroxysmal supraventricular tachycardia PSVT
Characteristics (Table 29.1)
ECG in PSVT
Treatment of PSVT
Nonparoxysmal AV Junctional Tachycardia (Fig. 29.17)
Probable site of origin and other features.
Treatment
Differential Diagnosis (Table 29.2)
INTRODUCTION
ASSOCIATED ARRHYTHMIAS
ETIOPATHOGENESIS
NORMAL PATHWAY
CLINICALLY
INHERITANCE
INVESTIGATION
Other Special Investigations
SIGNIFICANCE OF PRE-EXCITATION SYNDROME
RISK STRATIFICATION
Treatment
WPW Syndrome and AF
WPW Syndrome and SVT: Treatment is Difficult
INTRODUCTION
CHARACTERISTIC ECG CHANGE IN VENTRICULAR ARRHYTHMIA
ENTITIES THAT FALL UNDER VENTRICULAR ARRHYTHMIAS
Ventricular Premature Beats (VPB)
Types of VPB
Differential Diagnosis (Refer to Table 29.3)
Features of Malignant VPB
VENTRICULAR TACHYCARDIA (VT)
Definition
Features
ECG (Fig 29.20)
ECG Criteria for VT
Other Features in VT
Features Often Associated with VT
Etiology of VT
Pathophysiology
Pathogenesis of ECG Morphology
Clinical Features of VT
Symptoms
Signs
Significance of ventricular tachycardia
Treatment of VT (Flow charts 29.2 and 29.3)
To Prevent Recurrence
Alternative
Classification of VT as per ECG Morphology of QRS
Polymorphic cause
Monomorphic
Polymorphic VT.
ECG PATTERN IN TORSADE DE POINTES
Electrophysiology
Causes of Torsade de Pointes
Torsade de Pointes in Normal Heart
Treatment of Torsade de Pointes
VT in congenital QT syndrome
Treatment of Congenital Long QT Syndrome
Other Conditions Causing Broad Complex Tachycardia
Capture beat
Fusion beat
VENTRICULAR FIBRILLATION
Synonyms
Definition
ECG
Clinically
Risk Factors
Causes
Pathogenesis
Treatment of VF
Cardioversion: Transthoracic Cardioversion
Procedure
Indications
Procedure of DC Shock
Synchronization
Energy Levels
Complications of Cardioversion (rare)
Digoxin Toxicity
Implanted pacemaker in cardioversion
Transvenous cardioversion
BRADYCARDIAS
Causes
Pathogenesis
Clinical Features of Bradyarrhythmias
Investigations
SINUS BRADYCARDIA
Other Bradycardias of Sinus Node Origin
ATRIOVENTRICULAR BLOCK/HEART BLOCK
Conditions Producing
Three Types
First Degree Heart Block (Fig. 29.22)
Second Degree Heart Block (Fig. 29.24)
Treatment
Mobitz type II (Fig. 29.26)
Treatment
Third Degree Heart Block/Complete Heart Block
Treatment
Management: Cardiac Pacing
Indications
Indications
Bundle Branch Blocks and Fascicular Blocks
FASCICULAR BLOCKS
Bifascicular Block
ARTIFICIAL CARDIAC PACEMAKERS AND TYPES (FLOW CHART 29.5)
Types of Pacing Modes
Modes of Pacing
Rate Responsive Pacemakers
Complications of Pacemaker
ANTIARRHYTHMIC DRUGS
CHAPTER 30:
Primary Diseases of the Myocardium
CHAPTER 31:
Pericardial Diseases
NORMAL PERICARDIUM
Functions
ETIOLOGY OF PERICARDIAL DISEASES
Causes
Pathogenesis
Clinical Features
Diagnosis
ECG
Course
Treatment
Complication
COMPLICATIONS OF PERICARDITIS
Definition
Types
Effects
Etiology
CHRONIC PERICARDIAL EFFUSION
Definition
Causes
Types of Effusion
Pathogenesis
Clinical Features of Chronic Pericardial Effusion
Symptoms
Signs
Investigations
CXR
Echocardiography
Other Investigations
Blood tests
Prognosis
Treatment
A Note on Mechanism of Pulsus Paradoxus
Definition
Types
Acute Causes
Chronic Causes
Hemodynamics of Tamponade
Effects of Tamponade
Amount of Pericardial Fluid
Clinical Features and Diagnosis
Onset Sudden.
Plus
Tamponade forms differential diagnosis for unexplained hypotension.
Note
Diagnosis
Investigations
Differential diagnosis of cardiac tamponade
Therapy
Pericardiocentesis
Procedure
Complications
Follow up care
Specific therapy:
Surgery
Indications
Procedures
CONSTRICTIVE PERICARDITIS (PICK'S DISEASE)
Causes
Pathogenesis
Pulmonary Venous Pressure
Systemic Venous Pressure Elevated
Diagnosis
Investigations
Treatment
Tuberculous Pericardial Constriction
OTHER TYPES OF PERICARDIAL DISEASES
Myxedema
Cholesterol Pericarditis
Chylopericardium
Congenital
CHAPTER 32:
Diseases of Aorta
TYPES
ETIOLOGY
PATHOGENESIS
ANEURYSM OF ASCENDING AORTA (FIG. 32.1A)
ANEURYSM OF AORTIC ARCH (FIG. 32.1B)
ANEURYSM OF THORACOABDOMINAL AORTA (FIG. 32.1C)
ANEURYSM OF ABDOMINAL AORTA
Complication
Diagnosis
Rupture
Surgery
Key Points/Summary
Symptoms
Signs
Other potentially useful investigations
Surgery
Interventional therapy
Medical Therapy
Glue Technique
Endovascular surgery
Long-term therapy and follow up
CHAPTER 33:
Pulmonary Embolism
DEFINITION
ETIOLOGY
PATHOPHYSIOLOGY
INVESTIGATIONS
MANAGEMENT
Anticoagulation
Indications
Dose
Advantages
Drug
Filters
CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTPHT)
CHAPTER 34:
Primary Pulmonary Hypertension
INTRODUCTION
Symptoms
Signs of Pulmonary Hypertension
Inspection
Palpation
Auscultation
In late stages: Complications
Cyanosis in PPH
Mechanisms
Other Late Signs
DIFFERENTIAL DIAGNOSIS AND METHODS TO DIAGNOSE
PATHOGENESIS OF PPH (FIG. 34.1)
Summary of Pathogenesis
Etiology and Inciting Causes of PPH
Cause of frequent late diagnosis:
Clinical Course of PPH
Investigations in PPH
Specific Investigations in PPH
TREATMENT
Prognosis
Complications
Associations of PPH
PROPHYLAXIS
DIFFERENT TYPES OF PULMONARY HYPERTENSION WITH POTENTIAL CAUSES
CHAPTER 35:
Cardiopulmonary Resuscitation
CARDIAC ARREST
ELECTROCARDIOGRAPHIC ABNORMALITIES CAUSING CARDIAC ARREST
1. Ventricular Fibrillation
2. Ventricular Asystole
3. Electromechanical Dissociation
Asystole and Electromechanical Dissociation (PEA)
TECHNIQUE OF CARDIOPULMONARY RESUSCITATION (AHA GUIDELINES 2005)
CPR
Chain of Survival
Aim of BLS
ALS
PROTOCOL FOR BASIC LIFE SUPPORT (BLS) (TWO RESCUERS PREFERRED)
STEP I
STEP II
STEP III
ESSENTIAL MODIFICATIONS MADE IN THE CURRENT GUIDELINES
Complications of CPR
ADVANCED CARDIAC LIFE SUPPORT (ACLS/ALS)
Protocol of Advanced Cardiac Life Support for Adults (AHA 2005 Guidelines) (Flow charts 35.2 and 35.3)
PHARMACOLOGICAL AGENTS DURING ADVANCED LIFE SUPPORT
Route of Drug Administration
CHAPTER 36:
Pregnancy and the Heart
NORMAL CIRCULATORY CHANGES
Physiological Anemia in Pregnancy
Innocent murmurs in pregnancy
Modification of Pathological Murmurs in Pregnancy
HEART DISEASES IN PREGNANCY
Management
Check ups
Treatment
CHAPTER 37:
Systemic Diseases and the Heart
DIABETES
OTHER ENDOCRINE DISEASES
Hyperthyroidism
Hypothyroidism
Cushing's Syndrome (Glucocorticoids Excess)
Addison's Disease
Conn's Disease
Pheochromocytoma
Acromegaly
Carcinoid Syndrome
OBESITY
MALNUTRITION AND VITAMIN DEFICIENCY
COLLAGEN VASCULAR DISEASES
Rheumatoid Arthritis
Systemic Lupus Erythematous
Ankylosing Spondylitis
Gout
INHERITED CONNECTIVE TISSUE DISEASE
Marfan's Syndrome
INFILTRATIVE DISEASES
Amyloidosis
Hemochromatosis
Sarcoidosis
NEUROLOGICAL DISEASES
Friedreich's Ataxia
Guillain-Barré Syndrome
Muscular Dystrophy
LUNG DISEASES
HEMATOLOGICAL CONDITIONS
Sickle Cell Disease
Anemia
OTHER CONDITION
Malignancy Involving the Heart
Infections and the Heart
Alcohol and the Heart
Beverages and the Heart
Electrolyte Imbalance
INDEX
TOC
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