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Aspiration Cytology of the Lymph Node
Riti Sinha
1:
Reactive Lymphoid Hyperplasia
Introduction
Anatomy of the Lymph Node
Infectious Diseases
Immunological Diseases
Malignant Diseases
Lipid Storage Diseases
Endocrine Diseases
Other Disorders
Causes
Acute
Chronic
Reactive Lymphoid Hyperplasia
Cytomorphology of Follicular Hyperplasia
Centrocytes
Centroblasts
Immunoblasts
Plasma Cells
Plasmacytoid Cells
Histiocytes
Lymphohistiocytic Aggregates
2:
Non-Neoplastic Conditions of the Lymph Node
Suppurative Lymphadenitis
On Cytomorphology
Infectious Mononucleosis (IM)
On Cytomorphology
Cytomorphology of the Immunoblast
Non-malignant Conditions
Malignant Conditions
Kikuchi-Fujimoto Disease
Differential Diagnoses
On Cytomorphology
Morphology of the Phagocytic Histiocytes
Morphology of the Non-phagocytosing Histiocyte
Morphology of the Plasmacytoid Monocyte
Cryptococcal Lymphadenitis
Toxoplasma Lymphadenitis (TL)
On Cytomorphology
Differential Diagnosis
Benign Disorders
Malignant Disorders
Differential Diagnosis of Toxoplasma Organisms
Cat-Scratch Disease
On Cytomorphology
Suppurative Granuloma
Differential Diagnosis
Castleman's Disease
Cytomorphology of the Hyaline Vascular Type
Systemic Lupus Erythematosus (SLE)
On Cytomorphology
Differential Diagnosis
Bacille Calmette-Guérin Lymphadenitis
On Cytomorphology
Tubercular Lymphadenopathy
Spectrum of Cytomorphological Patterns
On Cytomorphology
Benign Sinus Histiocytosis
On Cytomorphology
Langerhans Cell Histiocytosis
On Cytomorphology
Cytomorphology of Langerhans Cell
Differential Diagnosis
Dermatopathic Lymphadenitis
Causes of Dermatopathic Lymphadenitis
On Cytomorphology
Differential Diagnosis
Sinus Histiocytosis with Massive Lymphadenopathy (SHML) or Rosai Dorfman Disease
On Cytomorphology
Immunocytochemistry
Proposed Classification of Histiocytic Disorders by Histiocytic Society
Differential Diagnosis
Lymphangiomas
On Cytomorphology
3:
Non-Hodgkin's Lymphoma
Lymphoid Malignancies
Proposed World Health Organization Classification of Neoplastic Diseases of the Lymphoid Tissues
B Cell Neoplasms
T Cell Neoplasms
Hodgkin's Lymphoma (Hodgkin's Disease)
Revised European-American Classification of Lymphoid Neoplasms (REAL)
B Cell Neoplasms
T Cell and Putative NK Cell Neoplasms
Hodgkin's Disease
Principles of Cytological Diagnosis of Lymphomas
B Cell Lymphomas
Small Lymphocytic Lymphoma
FNAC Findings
Ancillary Studies
Differential Diagnosis
Follicular Lymphomas (FL) (Figs 3.1 to 3.3)
Grading Follicular Lymphomas (FL)
FNAC Findings of FL
WHO Grading System
Grade versus Pattern
Lymphoplasmacytic Lymphoma
FNAC Findings
Ancillary Studies
Differential Diagnosis
Mantle Cell Lymphoma
FNAC Findings
Ancillary Studies
Differential Diagnosis
Marginal Zone B Cell Lymphoma
FNAC Findings
Cytomorphology of the Monocytoid B cells
Ancillary Studies
Differential Diagnosis
Anaplastic Large Cell Lymphoma (ALCL) (Figs 3.4 to 3.8)
Ancillary Studies
Differential Diagnosis
Diffuse Large B Cell Lymphoma (DLBL)
FNAC Findings
Large Cleaved Cell Lymphomas
Large Non-cleaved Cell Lymphomas
Aspirates with Predominant Immunoblastic features
Ancillary Studies
Differential Diagnosis
Burkitt's Lymphoma
FNAC Findings
Differential Diagnosis
Precursor B Cell and T Lymphoblastic Lymphoma
FNAC Findings
Ancillary Studies
Peripheral T Cell Lymphoma (PTCL) – Not Otherwise Specified (NOS)
4:
Hodgkin's Disease
Hodgkin's Lymphoma (HL)
FNAC Findings
Cytomorphology of the Classic RS Cells
Cytomorphology of the Hodgkin's Cell
Cytomorphology of the Lacunar Cells
Cytomorphology of the Lymphocytic and Histiocytic Cell (L and H Cell)
Non-neoplastic Cells
Nodular Sclerosis (NS) Hodgkin's Lymphoma
Mixed Cellularity Hodgkin's Lymphoma
Lymphocyte Depletion Hodgkin's Lymphoma
Nodular Lymphocyte Predominance Hodgkin's Lymphoma
Ancilliary Studies
Cells that Mimimic RS Cells
Differential Diagnosis
5:
Metastatic Malignancies to the Lymph Node
Introduction
Melanomas (Figs 5.1 to 5.6)
Differential Diagnosis of the Pleomorphic Epithelioid Cell Variant
Differential Diagnosis of the Spindle Cell Variant of Melanoma
Squamous Cell Carcinoma (Figs 5.7 to 5.11)
Cytomorphology
Differential Diagnosis
Cytomorphology of Branchial Cleft Cyst
Nasopharyngeal Carcinoma (Figs 5.12 to 5.16)
Cytomorphology
Differential Diagnosis
Papillary Carcinoma of the Thyroid (Figs 5.17 to 5.20)
Cytomorphology
Tall Cell Variant of Papillary Carcinoma of the Thyroid
Cytomorphology
Metastasis of Germ Cell Tumors
Seminoma
Immunocytochemistry
Metastasis of Breast Carcinoma to the Lymph Node (Figs 5.21 and 5.22)
Metastatic Adenocarcinoma (Figs 5.23 to 5.27)
INDEX
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