The study of movement disorders dates back to antiquity and reference to shaking hands are available even in ancient Sanskrit scriptures, like hasta kampa, meaning tremor. The use of Mucuna pruriens, which contains dopamine, was established long ago and has been referred to in our old texts. However, the study of movement disorders, as we know today, has its roots in the western world and this article will deal with the works of some of the legendary neuroscientists whose works in this field are remarkable.